Shamphavi Sivabalasarma

Regulation of YAP activity by nuclear G-actin binding The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between cytoplasm and nuclear compartment. YAP and its paralog TAZ (transcriptional co-a...

Hi all, check out our new preprint where we uncover:"Regulation of YAP activity by nuclear G-actin binding", www.biorxiv.org/cgi/content/...
#actin #YAP/TAZ #transcription #nucleus with help from Sonja-Verena Albers
‪@archaellum.bsky.social‬

Finally out of embargo!!
Happy to be among the recipients of a Chaire d'excellence from @agencerecherche.bsky.social
www.enseignementsup-recherche.gouv.fr/fr/media/37482
to further knowledge on #archaea #methanogens of the human #microbiome. We'll be very busy for the next 5 years @pasteur.fr !!

Congrats Simonetta! 🎉

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors Nature Microbiology - Phylogenetic reconstructions with conserved protein markers from the 11 known DPANN phyla reveal their monophyletic placement within the Euryarchaeota.

📣 We are proud of the publication of the second paper of @bbaker24.bsky.social PhD thesis. In collaboration with friends in Halifax we have studied the difficult question of the phylogeny of the DPANN archaea, composed of several phyla of highly reduced, fast-evolving epiparasites 🧵

rdcu.be/erkkU

Archaeal S-layer proteins can adopt different symmetries that can locally accommodate areas of high curvature. The S-layer is also involved in the control of turgor and osmotic pressure, ion transport, cell-cell interactions and mating.

The S-layer is the most widespread and fundamental component of archaeal cell envelopes and may represent one of the earliest and most fundamental cell wall polymers found in microorganisms

The archaeal S-layer is not only pretty, it also carries crucial cellular functions, and the list keeps growing! @sshamphavi.bsky.social @marleenvw.bsky.social @archaellum.bsky.social and I wrote a little sheath sheet (+10 pts if you got the pun)
📖 Curr Opin Cell Biol
🔗 doi.org/10.1016/j.ce...

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo Nature Physics - Oscillatory Min protein patterns prevent abnormal bacterial cell division. Now it is shown that Min pattern formation is resource efficient and involves wavelength-invariant...

Our paper on the E. coli Min system in vivo with @physicsoflifelmu.bsky.social & Judy Kim (UCSD) has been published in Nature Physics today. Tight integration of experiment and theory, and physiology and biophysics. Incredible perseverance of our young students. rdcu.be/ekIpO

Preprint alert! I’m publishing my last paper from my postdoc work on archaeal cell biology, with @mullinslab.bsky.social, @archaellum.bsky.social, @samjlord.bsky.social, @marleenvw.bsky.social, @arghya93.bsky.social, and more great folks (thread below with more details)

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Eukaryotes' closest relatives are internally simple syntrophic archaea Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...

New isolates from eukaryote's closest archaeal relative: ‘Hodarchaeales’!! Syntrophic microaerotolerant peptide-degrading anaerobic archaea w/ simple cell structure & protrusions. Features conserved across the phylum provide new insight into our ancestor’s biology!
www.biorxiv.org/content/10.1...

Congrats!🎉

#MicroSky

Horizontal gene transfer of the functional archaellum machinery to Bacteria Motility in Archaea is driven by a nanomachinery called the archaellum. So far, archaella have been exclusively described for the archaeal domain; however, a recent study reported the presence of arch...

Very cool stuff, the first archaellum (a.k.a. archaeal flagellum) found in bacteria. And not just the genes, but the actual structure and indirect evidence that it propels cells www.biorxiv.org/content/10.1... Research by @sshamphavi.bsky.social in @archaellum.bsky.social 's lab (et al., of course)

Actually the other way round;) Bacteria got the archaea-specific archaellum from Archaea!

Horizontal gene transfer of the functional archaellum machinery to Bacteria Motility in Archaea is driven by a nanomachinery called the archaellum. So far, archaella have been exclusively described for the archaeal domain; however, a recent study reported the presence of arch...

"~demonstrating the successful expression and assembly of this (Archaeallum) machinery in Bacteria and its function in swimming motility."

Horizontal gene transfer of the functional archaellum machinery to Bacteria
www.biorxiv.org/content/10.1...

wuhuu and it's out! Check out our latest Preprint on Bacteria using archaella for swimming! So much fun figuring it out and great collab with @mariejoest.bsky.social @loumollat.bsky.social Najwa Taib and @sgribaldo.bsky.social

Great work spearheaded by @sshamphavi.bsky.social, @loumollat.bsky.social and @mariejoest.bsky.social in the lab and Najwa Taib from @sgribaldo.bsky.social lab!

And we thank Stefan Steimle for his help at the cryoEM Facility at the @uni-freiburg.de Funded by @sfb1381.bsky.social 1/n

The Molecular Biology of Archaea lab is now a little longer than 10 years at the @uni-freiburg.de at @biologyunifreiburg.bsky.social !
I want to thank all the members of the group (PhD students, Postdocs and technicians) and all the students for making this an exciting place to do science!

The Archaellum – The Motility Structure of Archaea by Sonja-Verena Albers and Ken Jarrell — The two prokaryotic domains, Archaea and Bacteria may share the same general body plan and be hard to tell apart at a glance, but they differ in many of their ...

time flies - ten years ago, @archaellum.bsky.social introduced the archaellum to STC #MicroSky #ArchaeaSky
schaechter.asmblog.org/schaechter/2...

The archaeon Sulfolobus acidocaldarius has four different surface filaments. Each of them plays its special role in motility, adhesion, biofilm formation and mating. Our latest cryoEM foray into three of these unique structures is now published: www.nature.com/articles/s41...

More collaborative Type IV pili work: Beautiful work from Phil Guo from Jun Liu's lab in collaboration with Lori Burrows and Lynne Howell on the in-situ architecture of the P. aeruginosa Type IV pilus machine where we played a small role. https://buff.ly/4fw9BZO

Use This Extension to Find All Your X Followers on Bluesky If you're looking to finally leave Elon Musk's X, Bluesky is one of your best alternatives—and Sky Follower Bridge is a web extension that will easily help you find all of your X followers there.

It seems that Blusky is having an actual momentum of growth, but it does take time to find all the accounts one used to follow in the other app. Just found out now about Sky Follower Bridge to ease migration from X (former Twitter) to Blusky lifehacker.com/tech/use-thi...

What is the role of MinD proteins in Archaea? They are not involved in positioning of the cell division proteins, but might rather position the archaellum machinery at the poles and interact with cytosceletal proteins. New paper alert coming!

Check out the nice thread on the killer archaea paper 🔪🦠 great collab!

How #archaea toggle the #nitrogen-uptake switch: By tightly regulating N uptake, they avoid overeating and thus wasting energy.

New paper by Marie-Caroline Müller, Tristan Wagner et al in Communications Biology

#enzyme #methanogen

mpi-bremen.de/en/Page6155....

www.nature.com/articles/s42...