Nicolas Renier

Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling - Nature Communications This study reveals that SHANK3 deficiency in brain endothelial cells disrupts BBB function during the neonatal period through β-Catenin imbalance, leading to ASD-related neuronal and behavioral abnorm...

New study published in @naturecomms.bsky.social shows a link between #Autism (in this case Shank3 mutation) and #BloodBrainBarrier integrity, following our foot steps linking endothelial abnormalities and autism. Very exciting ! (we are actually working a something similar)

We're organizing the 4th iDISCO / TRISCO workshop at @rockefelleruniv.bsky.social in NYC!
April 14-19 - FREE - registration to kavlifellows@mail.rockefeller.edu. Deadline: March 1st.

We'll talk about brain mapping of cells, genes, axons, vasculature, light sheet microscopy, tissue clearing.

This is IT: we’ve been using their method for about 1 year now, it is wonderful