Rosalind & Morris Goodman Cancer Institute

The Multifaceted Role of Osteopontin in Modulating the Tumor Microenvironment Abstract. Osteopontin, a key structural protein in the extracellular matrix, plays a pivotal role in regulating the local tumor microenvironment and systemic immunity during cancer progression. Recognizing that tumor cells do not exist in isolation but rather interact with a multitude of stromal components that significantly influence patient outcomes and therapy responses, this review focuses on the role of osteopontin in non-tumor cells in the context of solid cancers and the associated phenotypic and mechanistic insights. We explore how osteopontin influences the behavior of various innate and adaptive immune cells, including natural killer cells, neutrophils, macrophages, dendritic cells, myeloid-derived suppressor cells, B cells, T cells, as well as structural stromal cells such as fibroblasts, endothelial cells, and adipocytes. The review highlights the roles of osteopontin in modulating these stromal cells and their multiaxial influence on tumorigenesis and metastasis. These complex interplays offer insights into potential diagnostic and therapeutic strategies around osteopontin/stromal-mediated pathways in cancer progression and recurrence.

(EN) A recent #review from GCI trainee Yu Gu published in Cancer Research (@aacrjournals.bsky.social) brings valuable insights to ongoing conversations in #cancer research. She explores the role of osteopontin in the tumour #microenvironment. Read the full review: doi.org/10.1158/0008...

The Multifaceted Role of Osteopontin in Modulating the Tumor Microenvironment Abstract. Osteopontin, a key structural protein in the extracellular matrix, plays a pivotal role in regulating the local tumor microenvironment and systemic immunity during cancer progression. Recognizing that tumor cells do not exist in isolation but rather interact with a multitude of stromal components that significantly influence patient outcomes and therapy responses, this review focuses on the role of osteopontin in non-tumor cells in the context of solid cancers and the associated phenotypic and mechanistic insights. We explore how osteopontin influences the behavior of various innate and adaptive immune cells, including natural killer cells, neutrophils, macrophages, dendritic cells, myeloid-derived suppressor cells, B cells, T cells, as well as structural stromal cells such as fibroblasts, endothelial cells, and adipocytes. The review highlights the roles of osteopontin in modulating these stromal cells and their multiaxial influence on tumorigenesis and metastasis. These complex interplays offer insights into potential diagnostic and therapeutic strategies around osteopontin/stromal-mediated pathways in cancer progression and recurrence.

(FR) Une récente revue de littérature par Yu Gu, étudiante à l'ICG, publiée dans Cancer Research (@aacrjournals.bsky.social) développe sur le rôle de l'ostéopontine dans le #microenvironnement tumoral. Article complet: doi.org/10.1158/0008...

Why does MET exon 14 skipping matter? It is more than a mere oncogenic mutation!😱🫁

Hot off the @biochemsoc.bsky.social press where we discuss met exon 14 and beyond
@mcgillgci.bsky.social

portlandpress.com/biochemsoctr...

(EN) For its 20th anniversary, @cp-cellmetabolism.bsky.social is spotlighting researchers who defined the field of metabolic science. Featured is @kazaklab.bsky.social, GCI Researcher, recognized for postdoctoral work on creatine metabolism. Article: tinyurl.com/mfdbakyz

(FR) Pour son 20e anniversaire, le journal @cp-cellmetabolism.bsky.social célèbre des auteurs qui ont contribué à la recherche métabolique. @kazaklab.bsky.social, chercheur à l’ICG, est célébré pour son travail postdoctoral sur du métabolisme de la créatine. Article: tinyurl.com/4t6ukex2

(EN) A new study co-led by Morag Park, GCI Investigator, and Christopher Moraes, GCI Associate Member, in collaboration with Jiannis Ragoussis, reveals insights into the role of cancer-associated #fibroblasts in the spread of triple-negative #breastcancer. Full article: tinyurl.com/yz4ey5u5

(FR) Une étude codirigée par Morag Park, chercheuse à l'ICG, et Christopher Moraes, membre associé de l’ICG, en collab avec Jiannis Ragoussis, présente des résultats sur le rôle #fibroblastes associés au cancer dans la propagation du #cancerdusein triple-négatif. Article: tinyurl.com/mr279dn6

Signaux longue distance et métastases de cancer du sein : une histoire de neutrophiles | Institut du cancer Goodman Une nouvelle étude menée par Hannah Garner, Ph.D., nouvellement chercheuse à l’Institut du cancer Rosalind et Morris Goodman (ICG), publiée dans le journal Cancer Cell, a montré que les cellules...

Une étude mené par @hannahgarner.bsky.social (ICG), montre que les précurseures des #neutrophiles reçoivent des signaux des tumeurs mammaires et aident les #métastases. Collaboration avec @nkinl.bsky.social, Moreno Martinovic, Karin de Visser et @dewitlab.bsky.social. Détails: tinyurl.com/4b5n5psu

Long distance signalling and breast cancer metastatic spread: a neutrophil story | Goodman cancer Institute A recent study from Hannah Garner, Ph.D. and new member of the Rosalind and Morris Goodman Cancer Institute (GCI), published in Cancer Cell, showed that neutrophil precursors located in the bone marrow receive signals from mammary tumours and promote metastasis.

A new study co-led by GCI member @hannahgarner.bsky.social showed how #neutrophil precursors receive signals from mammary tumours and promote #metastasis. Incredible collaboration with @nkinl.bsky.social, Monreno Martinovic, Karin de Visser and @dewitlab.bsky.social. Details: tinyurl.com/4c2snae6...

Thrilled to announce that we are now accepting abstracts for #CCRC2025, November 2-4, 2025, in Calgary!

This is an excellent opportunity to share and discover cutting-edge research and findings across the research spectrum.

✍️Submit your abstract: ccra-acrc.ca/conference

ADN et cancer : un aperçu de la recherche en génomique | Institut du cancer Goodman Le 25 avril marque la Journée de l’ADN, une occasion de souligner les publications marquantes sur la structure de l’ADN et une célébration des accomplissements de la recherche en génétique. Les progrès de la recherche sur l’ADN et la génomique ont révolutionné notre compréhension du cancer, menant à des améliorations significatives pour la détection, le suivi et le traitement du cancer. À l’Institut du cancer Rosalind et Morris Goodman (ICG), nos chercheurs et chercheuses sont à la pointe de la biologie du génome du cancer.

Aujourd'hui est le Jour de l'#ADN! Nous célébrons les avancées de la recherche en génétique de travail de trois membres l'ICG, Sidong Huang, Ph.D., Josée Dostie, Ph.D. et Xiang-Jiao Yang, Ph.D., qui mènent des recherches en biologie du génome du cancer: tinyurl.com/mr3jevdb

Collaboration is key to driving cancer research. @kazaklab.bsky.social, Ph.D., @kazaklab co-organizer of the inaugural #AdiposeBiology Conference in Montreal, on August 19-20, 2025. Early bird pricing is available until May 1st, 2025! Learn more: www.adiposebiology....

La collaboration est essentielle pour la recherche sur le cancer et pour trouver le #savoirpourguérir. @kazaklab.bsky.social, Ph.D., est co-organisateur de la Conférence sur la biologie des tissus adipeux à Montréal, qui aura lieu les 19 et 20 août prochains. Plus de détails: www.adiposebiology.com

Congratulations to @kazaklab.bsky.social and their collaborators for this new publication in @naturecomms.bsky.social!

The GCI is incredibly proud to be a part of this Pan-Canadian collaborative effort to improve outcomes for all Canadians living with cancer. Read the @marathonofhope.bsky.social first landmark paper in @cp-cancercell.bsky.social : www.cell.com/cancer-cell/...

La première édition de la Gazette ICG, une initiative étudiante de l'ICG, a été lancée le 7 février dernier! Cette publication présente des perspectives scientifiques, des projets en cours à l'ICG, des entretiens avec des étudiant.e.s et plus encore! Obtenez une copie: https://tinyurl.com/338f7ueb

The first edition of the @mcgillgci.bsky.social GCI Gazette was launched on February 7th! This student-led publication features scientific perspectives, interviews with trainees, and more! Get your copy: https://tinyurl.com/234j327f @mcgilluniversity.bsky.social

The @mcgillgci.bsky.social welcomed 15 students from across Canada for the Annual Graduate Recruitment Event. During their time here, they had a chance to meet faculty and trainees and have discussions on cancer research. Read more: https://tinyurl.com/2n99tt8f @mcgill.ca

Le @mcgillgci.bsky.social a accueilli 15 étudiant.e.s d'universités canadiennes pour l'événement annuel de recrutement. Pendant 2 jours, les étudiant.e.s ont visité l'Institut et ont échangé avec le personnel et les étudiant.e.s Détails: https://tinyurl.com/33k2s9v6 @mcgill.ca

Today is #WorldCancerDay, an initiative raising awareness about #cancer themed #UnitedbyUnique. We highlight two researchers from the @mcgillgci.bsky.social and the @cusm-muhc.bsky.social who work on precision cancer medicine: https://tinyurl.com/5n7wnu6f

Aujourd'hui est la #journéemondialecontrelecancer, une campagne de sensibilisation sur le #cancer sous le thème #unisparlunique. Deux chercheurs du @mcgillgci.bsky.social et du @cusm-muhc.bsky.social décrivent leur travail sur la médecine de précision contre le cancer: https://tinyurl.com/bddpk868