Vivek Mishra

Frequent longitudinal blood microsampling and proteome monitoring identify disease markers and enable timely intervention in a mouse model of type 1 diabetes - Diabetologia Aims/hypothesis Type 1 diabetes manifests after irreversible beta cell damage, highlighting the crucial need for markers of the presymptomatic phase to enable early and effective interventions. Curren...

Are you curious about blood microsampling to monitor changes in the circulating proteome?

Then check our team science study recently published in @diabetologiajnl.bsky.social where we study the effects of virus induced immune response and disease onset.

link.springer.com/article/10.1...

It's official: we're #hiring another #PhD student!
If you are interested in combining #SingleCell technology, #microscopy and #Drosophila genetics to investigate how cells become #cancerous contact me or apply directly under the following link:

stellenangebote.uni-marburg.de/jobposting/6...

Excited to share my first contribution here at Illumina! We developed PromoterAI, a deep neural network that accurately identifies non-coding promoter variants that disrupt gene expression.🧵 (1/)

I really recommend this! It’s amazing to see the manufacturing floors and how the sausages (reagents) are made!

Illumina Unveils Spatial Technology Days Before AGBT Meeting Illumina announces a new NGS-based spatial technology kit and new software platform, Illumina Connected Multiomics.

Illumina is finally venturing into spatial www.genengnews.com/topics/omics...

Illumina Single Cell 3’ RNA Prep kit is now available! Learn more here: www.illumina.com/products/by-...

Macrogen Consortium and Illumina partner to deliver Korean National Bio Big Data project. Illumina is proud to be selected as sequencing technology partner to the Macrogen Consortium and together we are honoured to support the Korean National Bio Big Data project by sequencing and analysin...

Macrogen, a sequencing service provider in Korea, has chosen #illumina high throughput sequencing to undertake their 145K human whole genome program. We've helped many large projects just like this with more to come. #genomics #PopulationGenomics #PrecisionMedicine #NovaSeqX #DRAGEN ilmn.ly/3ZJLIYo

A few days left to apply if you would like to work on spatial multi-omics modeling in an interdisciplinary team!

Wow!! 🤩

Are you interested in doing your #PhD in #cancer research using live imaging, #microscopy, #singlecell and #metabolomics on #Drosophila? Then apply directly under the link or contact me: katja.rust@uni-marburg.de

Please repost for visibility!

stellenangebote.uni-marburg.de/jobposting/4...

What is #illumina Constellation Technology? CTO, Steve Barnard introduces it in this webinar and the Niall Lennon from Broad MIT, takes it for a spin. Worth a watch!
#genomics #NovaSeqX

www.illumina.com/events/webin...

The first #Illumina #Miseqi100 has landed in Europe—guess who gets the honors? Of course, it’s @fgcz-en.bsky.social! This state-of-the-art sequencer joins our fleet, driving groundbreaking genomics research for the Zurich life science community.🧬

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...

Great work from @amandaanderssonr.bsky.social with Hans Clevers group modelling pancreas by creating organoids that develop all three pancreatic lineages www.cell.com/cell/fulltex...

@antobeck.bsky.social PIPseq is #somuchmore 😀

The lives of cells, recorded - Nature Reviews Genetics Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...

"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...

#PIPSeq V
#accessible #scalable and #flexible #singlecell solution for #everylab

Congratulations to your entire team on this monumental effort!!

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning Nature Communications - Multi-omics integration is often limited by data sparsity and heterogeneity. Here, the authors develop MOSA, a method designed to augment DepMap cell line data to...

Thrilled to share our first dive into generative models, integrating 7 distinct omics to generate a complete Synthetic Cancer Dependency Map for +1,500 cancer cell lines! Excited for what’s ahead. rdcu.be/d1TgQ #GarnettLab #CMRI #ProCan #INESC-ID #IST @naturecomms.bsky.social

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Immune cells change in proportions with age - naive go down, effector go up. www.science.org/doi/10.1126/...

The Human Cell Atlas: towards a first draft atlas Established in 2016, the Human Cell Atlas (HCA) consortium set out to create a comprehensive biological map of cells within the human body.

Exciting #milestone and #landmark achievement by @humancellatlas.bsky.social

www.nature.com/collections/...

I am excited about Pixelgen Technologies molecular pixelation assay for single cell spatial proteomics. They have a new new tech note out in collab with #illumina www.illumina.com/content/dam/...

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If #spatial #proteomics at #singlecell resolution is your thing, then checkout this latest co-branded app note by #Illumina and #Pixelgen

www.illumina.com/content/dam/...

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Please add me. Thank you!

Whole-brain spatial transcriptional analysis at cellular resolution

Incredible study - 3D single cell imaging of the entire mouse brain - also on the cover of this week's #Science
🧪🔬🤯

www.science.org/doi/10.1126/...