James Briscoe

Nice summary of a recent @dev-journal.bsky.social paper

It's always special when you find your own paper in the table of contents of the journal 😍

"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form

www.cell.com/developmenta...

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube Zhang et al. identify a global temporal chromatin program that operates across the developing vertebrate nervous system to control neural cell diversity. This mechanism, which involves Nr6a1 and NFIA/...

Good to see the peer reviewed version of this in print

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity

www.cell.com/developmenta...

Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...

Check out this month's handpicked preprints in developmantal & stem cell biology on the Node

thenode.biologists.com/prelighters-...

We have a new lab photo. Busy times in the Delas Lab!

Last month Maria and Shaun joined us to start their PhDs.

Learn more about our research and our team: delaslab.com

We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.

Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.

Congrats to Giulia and co 🍾🥂

📣 Paper alert!

I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...

Obituary: James Watson James Watson, the godfather of DNA who discovered the "secrets of life" has died aged 97.

BBC News - James Watson: Controversial discoverer of 'the secret of life'
www.bbc.com/news/article...

In preprints: multiomics of low temperature acclimation in the era of intensifying temperature fluctuations In a warming world, all life forms – endotherms and ectotherms alike – are finding their homeostasis being challenged. The environmental change is challenging at all stages of life. How different orga...

Working in a biomed institute, its natural to think about health & medical impact of dev bio but there's more to dev bio

Agriculture is dev bio (plant growth, livestock breeding)

And dev bio is important to understand environment & climate impact. See e.g:

journals.biologists.com/dev/article/...

Volume 152 Issue 20 | Development | The Company of Biologists

Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

journals.biologists.com/dev/issue/15...

First week in @jamesbriscoe.bsky.social lab at @crick.ac.uk!
1/n

44th Annual Oliver H. Lowry Lecture: 'The Dynamics of Neural Tube Development'

Looking forward to a day with the developmental biologists at WashU in St Louis.

Honoured to be giving the 44th Annual Oliver H. Lowry Lecture

4pm Jeffrey T. Fort NRB Building, Auditorium

happenings.wustl.edu/event/44th-a...

Evolutionarily conserved transcriptional regulators control monoaminergic neuron development To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in ...

New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...

Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks How do transcription factors, with pleotropic functions, generate organized cellular diversity in developing tissues? This study shows that PAX3 and PAX7 orchestrate spinal cord patterning by acting a...

Good to see this study from Ribes & co in print: PAX3/PAX7 transcription factors control neural tube patterning by simultaneously repressing ventral fates via H3K27me3 deposition at silencers & activating dorsal fates as pioneer factors at enhancers
@ribes
journals.plos.org/plosbiology/...

Home Home

Looking forward to a day visiting friends and colleagues at @stowersinstitute.bsky.social

Seminar at noon

www.stowers.org

Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*

For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social

www.biorxiv.org/content/10.1...

Beautiful, insightful study from Boezio et al. One of the best clonal analyses I’ve seen so far. We’ll dig in this week! Check it out!

Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*

For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social

www.biorxiv.org/content/10.1...

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social

We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇

www.biorxiv.org/content/10.1...

Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment

Photo of whale at Museum of Zoology and photo of 100 cake

This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.

Picture of #LifelongDevSI Guest Editor Mansi Srivastava taken in an office with a whiteboard and sunny window. Mansi is wearing a white shirt and a flower pendant necklace with colourful petals

Mansi Srivastava is a Guest Editor for our Special Issue on Lifelong Development #LifelongDevSI. In this interview, Mansi talks about her research path, the links between regeneration and development and the exciting questions her lab is trying to answer.

journals.biologists.com/dev/article/...

Poster of Development timeline and history

1953: The Company launches the Journal of Embryology and Experimental Morphology. In 1987, JEEM is renamed Development @dev-journal.bsky.social. Read their 100-year anniversary articles collection: bit.ly/42vDGED

European Molecular Biology Laboratory With support from more than 30 countries, laboratories at six locations across Europe and thousands of scientists and engineers working together, the European Molecular Biology Laboratory is a powerho...

Looking forward to a day at EMBL Barcelona for Science by the Beach

Seminar at noon

Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...