Ali Amini

We’re delighted to hear that our favourite cell type (Regulatory T cells!) have been recognised in the Nobel Prize this year! Huge congratulations to Mary, Fred, and Shimon for their pivotal work in the field & here’s to many exciting Treg advances to come!🥳👏🎉

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

Definitely more important than MHRA suicide risks. Five days ciprofloxacin up to year-long resistance in the gut microbiome (10 % got same gyrA mutation with no fitness cost). Probably had impact on tonic mucosal immune responses too.

Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Ex vivo models capture the cellular and functional richness of respiratory tract tissues and enable study of viral pathogenesis
www.science.org/doi/10.1126/...

Tuberculosis in NYC: Why have cases been on the rise? In the 1990s, NYC faced a surge of tuberculosis. The city bolstered its TB control program and brought those cases down. But in recent years, they’ve started to tick up again. Here’s what to know abou...

From 2022 to 2023 the city of new york reported a 28% increase in cases of tuberculosis. This article examines the reasons. The biggest one is the continued loss of public health funding.
www.healthbeat.org/newyork/2025...

Chart shows numbers of studies in data resource for Human Immunology Project consortium. more details at immunespace.org

Come get our #immune data, free #FAIRsharing is at @immportdb.bsky.social
- from @columbiauniversity.bsky.social
@icahn.bsky.social
@yalemedicine.bsky.social
@stanfordimmunology.bsky.social
@benaroyaresearch.bsky.social
@lji.org
MIT, Seattle Children's
#AAI2025
#ImmuneSky #IDsky

Deciphering the role of histone modifications in memory and exhausted CD8 T cells @ejohnwherry.bsky.social @amylizbaxter.bsky.social
www.biorxiv.org/content/10.1...

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature Medicine Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...

www.nature.com/articles/s41...
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.

Adjuvant mechanisms of action at the injection site. Antigen depots control the rate of antigen release at the injection site, where local inflammation and slow release of both antigen and adjuvant components influence cytokine and chemokine release and subsequent immune cell infiltration from the circulation. Adjuvants can also improve antigen capture by DCs and lymphatic drainage by nanoscale-particulate antigens and increase lymphatic flow leading to enhancement of the immune response.CREDIT: A FISHER/SCIENCE IMMUNOLOGY

Adjuvant effects in the draining lymph node. Adjuvants can have many effects at the draining lymph nodes, including (1) increasing lymph flow; (2) inducing deletion of sinus-lining macrophages, promoting antigen entry into the lymph node parenchyma; (3) promoting antigen capture on follicular DCs in GCs, e.g., via slow antigen release that promotes early immune complex formation or complement activation; (4) inducing the production of inflammatory cytokines and chemokines; (5) promoting influx of innate and adaptive immune cells from circulation; (6) activating innate immune cells, including APCs that up-regulate costimulatory receptors and prepare to present antigen to lymphocytes; and (7) promoting antigen processing and presentation, including cross-presentation of antigen to CD8 T cells by DCs.CREDIT: A FISHER/SCIENCE IMMUNOLOGY

Chemical structures of molecular adjuvants. Adjuvants in use alone or in combination, including the TLR4 agonist monophosphoryl lipid A (MPLA), STING agonist cyclic guanosine 5′-monophosphate (GMP)–adenosine 5′-monophosphate (AMP) (c-GAMP), QS-21 saponin, and TLR7/8 agonist imidazoquinoline 3M-052.CREDIT: A FISHER/SCIENCE IMMUNOLOGY

Adjuvant classes and structures. (A) Depot-forming adjuvants retain antigen for slow release and/or promote immune cell recruitment to the injection site to enable antigen capture and trafficking to draining lymph nodes. Examples of depot-forming adjuvants include aluminum salts, hydrogels, and cationic liposomes. (B) Oil-in-water or water-in-oil emulsions promote innate immune activation through inflammasome activation and induction of cell stress at the injection site and/or draining lymph nodes. (C) Saponins derived from Q. saponaria bark activate inflammasomes, trigger cytokine production, and increase lymph flow. (D) DAMPs or pathogen-associated molecular patterns (PAMPs) are ligands that activate specific pattern recognition receptors like TLRs or other sensors. (E) Combination adjuvant formulations. Transmission electron micrograph in (C) modified from

#Medsky🧪 #idsky #immunodky #pharmasky #publichealth Review discusses how #vaccine #adjuvants function & highlight knowledge gaps that need to be addressed to develop improved vaccines against emerging pathogens. @sciimmunology.bsky.social
scim.ag/430weCB

Pandemic monitoring with global aircraft-based wastewater surveillance networks - Nature Medicine By simulating the implementation of airport-based wastewater surveillance sites at the global level, a modeling study shows how this early warning system would perform in identifying sources of pandem...

#Medsky🧪#Idsky #immunosky #publichealth A study in @naturemedicine.bsky.social shows how global aircraft-based #wastewater surveillance networks would perform in identifying sources of pandemic outbreaks and what the optimal location of monitoring sites would be. go.nature.com/4gIknMm

An amazing team effort! Thanks to all the eosinophiles involved and @biainfection.bsky.social

Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social

www.nature.com/articles/s41...

Gut IgA1 and IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, and show unique changes of both frequency and reactivity in IBD @gmagrilab.bsky.social
doi.org/10.1084/jem....

Current and future strategies for the prevention and treatment of cytomegalovirus infections in transplantation Abstract. Successful prevention and treatment of cytomegalovirus (CMV) infection remains a central focus of clinical care in solid organ and allogeneic hem

Really great review for the ID trainee (and refresher for the ID provider) #IDSky @cidjournal.bsky.social

academic.oup.com/cid/advance-...

Posting this because these images are making the rounds again. Plus, someone told me it was the best thing I ever did, and I was flattered.
p.s. only possible since I've been directly involved with several papers that meet these exact criteria, so mea culpa
blogs.jwatch.org/hiv-id-obser...

Most accurate Oded post ever...

Radiology reports, 2040: brain volumes commensurate with age and genotype. In depth phenotyping of UK biobank cohort never ceases to amaze!

Representative CD20 staining of spleen and mandibular lymph node sections from animals treated with vehicle or CD20-NKCE-IL2v (0.5 mg/kg). Scale bars: 3 mm

This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models!

bit.ly/SI_adp3720

OpenSAFELY Symposium 2024: there's still time to sign up | Bennett Institute for Applied Data Science It’s not too late to register for our 2nd Annual OpenSAFELY Symposium, which is happening in London on 25/26 November.

"Why doesn't the NHS use its GP data?". Because of privacy... Because it's hard... But we solved it. We developed new privacy protections... We built docs.OpenSAFELY.org! 181 projects! 31 organisations! Now, they come together, for the first time, in 3D!

www.bennett.ox.ac.uk/blog/2024/10...

🙋

Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k

Results 10 yrs metagenomic sequencing for CNS infections www.nature.com/articles/s41...

Impressive.

Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.

Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection Sickness-associated anorexia, the reduction in appetite seen during infection, is a widely conserved and well-recognized symptom of acute infection, y…

My first post - hi everyone! My lab was intrigued by the interaction between starvation and infrction so med student Jessy Jindal wrote a review, led by senior immunologist Barbara Kronsteiner. Very interesting evolved responses www.sciencedirect.com/science/arti...

go.bsky.app/LAZ4huB

A breakthrough cancer immunotherapy is now taking aim at autoimmune disease CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand

Treating lupus by depleting B cells with CAR T cells has been shown successful

A breakthrough cancer immunotherapy is now taking aim at autoimmune disease | Science | AAAS www.science.org/content/arti...

Multidisciplinary approach to lung transplant with indication of the teams involved

Contraindications and risk factors for poor outcomes in lung transplantation

The lung transplant process

Overview of chronic lung allograft dysfunction (CLAD)

Lung Transplantation

Review in NEJM

Jason D. Christie, Dirk Van Raemdonck, and Andrew J. Fisher

www.nejm.org/doi/full/10.... (paywall) Key images / table below
#TxID #TransplantSky

a man in a lab coat says no reason in front of a wall of cards Alt: a man in a lab coat says “no reason”

Y’all are going to need some infectious diseases experts

#IDSky Starter Packs

IDSky 1 go.bsky.app/LnAQjdq
IDSky 2 go.bsky.app/JNfSvQT
IDSky 3 go.bsky.app/FeogT7o
IDSky 4 go.bsky.app/D1zxj4E
IDSky 5 go.bsky.app/NgGSPeF
IDSky 6 go.bsky.app/22VBL8z

#MedSky

Was tumbleweed here after NY and ashamed to say thought it'd go the way of Mastodon without critical mass abandoning that which shall not be named 😬

Wonderful to see the #immunology community growing here.

The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD