Nicki Liachko

AD/ADRD peeps: Notice to expire the Research on Current Topics in Alzheimer's Disease and Related Dementias effective immediately. (Related R21 also expired in NOT-AG-25-023). grants.nih.gov/grants/guide...

Opening for a tenure-track biology Assistant Professor at the University of Washington's Bothell campus, just northeast of Seattle.

Chair of Pharmacology and Toxicology - Salt Lake City, Utah job with The University of Utah | 37914733 The University of Utah seeks a Chair of Pharmacology and Toxicology

After 10 years, I am stepping down as chair of our department and we have an active search going on! Utah is a phenomenal place to live and work and it's been the honor of a lifetime chairing the department founded by Lou Goodman. #MedSky #Neuroskyence Repost!

jobs.chronicle.com/job/37914733...

Scientists, especially Seattle ones! One of my research scientists is heading to her PhD and we're looking to fill her spot, if not replace her. If you know someone looking to do cool and impactful translational research give them this:

uwhires.admin.washington.edu/ENG/Candidat...

Absolute and Relative Declines in National Institutes of Health (NIH) Funded Basic Science Publications An analysis of over 2.2 million NIH-funded research papers published between 1990 and 2024 reveals that there have been marked declines in the relative and absolute numbers of basic-science oriented p...

Mike Lauer still putting data out there. www.biorxiv.org/content/10.1...

Fear and loathing on study section: Reviewing grant proposals while the system is burning As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.

i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now

www.thetransmitter.org/craft-and-ca...

Graffiti at the end of an underpass in Heidelberg saying 'LAB!'.

Some PIs will stop at nothing to motivate their lab members. 🧪

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

this is getting ridiculous (in a good way). first it's $15 plasmid sequencing, now it's $25 C. elegans genome sequencing.

time to look through our freezer collection at all the mutants we never followed up...

UAB is a fantastic place: great science, great people, and great trainees! The collaborative vibe spans across multiple departments. Also the food in Birmingham is legit amazing.

My colleague Dan beat me to the punch but I am so thankful that my hometown paper (and others) was willing to share this with the community.

Many in biotech/private sector are boasting about their ways of funding and doing science

But they are staffed with PhDs and postdocs we train in our NIH and NSF funded labs in universities

With university labs lacking funds to train, the private sector will be profoundly harmed

Jeanna’s an amazing instructor, highly recommend this for mental and physical health given *waves vaguely at the increasing chaos everywhere*

1/3 Why does the US lead the world in the number of clinical trials? How come americans are given the unique chance to get the latest treatment and a fighting chance against often incurable diseases?

That's all thanks to research and the support from the NIH!

Extremely disappointed to see HHMI decide to kill their Inclusive Excellence program, including terminating the current IE3 awards to over a hundred institutions effective this year in the middle of a 6-year grant. I was hoping HHMI (and other private funders) would continue to lead the way.

Any blanket will work in a pinch 🤪

Without downloading any new pics, where are you mentally?

NIH funding in WA state supports 11,979 jobs and $2.96 billion in broader economic impacts

Impact of NIH funding in WA state (from www.unitedformedicalresearch.org/nih-in-your-...)

This account is for sharing info with US scientists, both extramural and intramural to NIH, about attacks on science in the US.

Education is power, and we can help advocate for science and medicine together. 💪🧪

We are a team of NIH people. Please ask us questions you might have.

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.

Summer Workshop on the Dynamic Brain 2025 The Summer Workshop on the Dynamic Brain is an intensive, project-based residential course with a focus on the neurobiology of sensory processing, coding, and neural population dynamics.

Less than a week to apply for the Summer Workshop on the Dynamic Brain! 🐋🧠🌊

Apply by Feb. 1 to join us for this intensive, project-based residential course in the beautiful San Juan Islands.

🔗 alleninstitute.org/events/summe...

🧠📈

Wow, very important study, with implications for other transgenic models of AD, especially those with documented variability (which is many of them)

Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy (LATE)
alz-journals.onlinelibrary.wiley.com/doi/full/10....

#dementia #neuroscience #NeuroSky #MedSky #neurology

Alternative 3' UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD - PubMed Recent research has highlighted widespread dysregulation of alternative polyadenylation in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). H...

TDP-43 proteinopathy also provokes transcriptomic changes consistent with TDP-43 loss of function. The latest side project from Randall Eck in my group: pubmed.ncbi.nlm.nih.gov/39810199/

Join our team! CLARiTI Grants Manager The CLARiTI Grants Manager will oversee a $97 million grant portfolio, which includes 35 sub-awards distributed across the country. This position offers the opportunity to contribute significantly to a transformative, multi-site, FDA-regulated study that is shaping the future of Alzheimer's disease and related dementias research.

We're #hiring a CLARiTI Grants Manager to administer $97M in grants, including 35 national sub-awards, and drive grants management innovations at NACC! Join our dynamic team and help advance Alzheimer's research and discovery.

Learn more and apply: uwhires.admin.washington.edu/eng/candidat...

Workshop Applications - 25th International Worm Meeting Visit our website to learn more.

With how busy the start of the semester is, the #Worm25 organizers have announced an extension of the deadline to apply to organize a workshop at the conference!📣 You now have until January 31.

Read guidelines, examples of topics, & apply: buff.ly/3DTfvq3 🪱

Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans Abstract. To understand the function of cells such as neurons within an organism, it can be instrumental to inhibit cellular function, or to remove the cel

Nice C. elegans methods review in this month's Genetics:
Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans academic.oup.com/genetics/art...

@genetics-gsa.bsky.social

Welcome to Bluesky, Genetics Society of America
@genetics-gsa.bsky.social !

We have, of course, added you to the Model Organism Research Resources starter pack.
go.bsky.app/Npxsd7h

Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease - PubMed Since the initial identification of TMEM106B as a risk factor for frontotemporal lobar degeneration (FTLD), multiple genetic studies have found TMEM106B variants to modulate disease risk in a variety ...

Here's the latest work from my group! We built a C. elegans model of human TMEM106b proteinopathy by expressing the human gene in neurons. TMEM106b is a new kid on the block in terms of aggregating proteins. Long story short, it can driven neurodegeneration. pubmed.ncbi.nlm.nih.gov/36056242/

omg a student somehow accidentally wrote an email addressed to a faculty-wide NYU listserv and my inbox is now a master class on who understands the difference between a listserv and an email chain