Frits Franssen

Remote photoplethysmography (PPG) app-based prolonged opportunistic arrhythmia screening pathway for COPD doi.org/10.1183/2312...

Natural disasters affecting respiratory health and the underlying mechanisms #ERS doi.org/10.1183/1399...

Modeled evolution of the global economic and health burden of COPD from 2025 to 2050, considering trends in risk factors and an expanding population. Actions needed to reduce risk factors and improve treatments. #CHEST doi.org/10.1016/j.ch...

Pathophysiological mechanisms disrupting lung development. Early-life exposures, including genetic and epigenetic alterations, infections, oxidative stress, and inflammation, contribute to impaired lung development. doi.org/10.1146/annu... #worldlungday

Having had just 1 moderate exacerbation in the year prior to COPD diagnosis significantly increases the risk of future events, suggesting that placing patients with 0 or 1 moderate event in the same low risk of future exacerbation groups (A & B) in GOLD is not justified doi.org/10.1183/1399...

Multiple direct and indirect pathways increase risk of lung disease exacerbations during heat waves. Community preparedness and advocacy are needed, particularly to address greater adverse effects on vulnerable populations. doi.org/10.1164/rccm... @atsblueeditor.bsky.social

New US study shows that COPD confers a 1.9-fold higher risk of intensive care unit admission or in-hospital mortality in adults hospitalized with RSV doi.org/10.1093/ofid... #virus #RSV

COPD patient survey shows that >20% of patients are not on maintenance therapy; leading reasons include that their COPD was not severe enough, and that their doctors had not recommended it. Action is needed for more effective and timely disease management. #COPDfoundation doi.org/10.15326/jco...

Airway mucus plugs were previously associated with increased risk of exacerbations and mortality in COPD. Now, persistent and newly formed mucus plugs are associated with a faster decrease in lung function (FEV1) in this disease. @nejm.org www.nejm.org/doi/abs/10.1...

Newly proposed diagnostic schema for COPD using major and minor criteria classifies individuals as having this disease beyond airflow limitation and identifies individuals at increased risk for poor outcomes. doi:10.1001/jama.2025.7358
@jama.com

Pulmonary rehabilitation is an evidence-based, personalized, comprehensive intervention that improves physical and psychological function and reduces healthcare consumption in people with chronic respiratory conditions #PRweek2025 #COPD

Almost 31% of persons hospitalized with severe RSV infection has underlying COPD and in-hospital mortality in this group may be as high as 18%. Preventive vaccins are available but need to be implemented. www.springernature.com/gp/open-rese...

Targeting T2 inflammation or epithelial-derived alarmins represents a step forward in precision medicine for the treatment of a subset of COPD... www.sciencedirect.com/science/arti...

Theoretical framework illustrating the potential impact of body composition on COPD exacerbation risk; from our latest editorial in Respirology #felipemachado doi.org/10.1111/resp...

Hard to comprehend and even harder to accept: a 46.3%, or 35 year, loss of life expectancy in the Gaza Strip during the period October, 2023, to September, 2024. Touched by this @thelancet.bsky.social paper. doi.org/10.1016/S014...

New meta-analysis shows a significant 20% reduction in all-cause mortality with ICS-containing therapies versus non-ICS containing inhaler therapies in COPD. Future research should identify patient subgroups most likely to benefit while minimizing adverse effects. doi.org/10.1080/1747...

The worldwide prevalence of shortness of breath in adults is approx. 14%, with a wide variation across sites. Furthermore, it is strongly associated with spirometric obstruction and restriction. #BOLD www.sciencedirect.com/science/arti...

PDE3 and PDE4 contribute to inflammation and airway smooth muscle contraction, that is evident in conditions such as COPD. Dual inhibition of these enzymes may provide clinical benefit to a broad range of patients with COPD and represents a promising new treatment strategy. doi.org/10.15326/jco...

Proposal for the management of cardiovascular risk factors and disease in patients with COPD doi.org/10.1080/1477...

Impact of home non-invasive ventilation in chronic hypercapnic respiratory failure due to COPD. Initiation of home noninvasive ventilation in hypercapnic chronic obstructive pulmonary disease: when, where, and how? - PubMed (nih.gov)

Patient-reported outcome measures (PROMs) are poorly related to clinical measures in severe asthma, but PROMs are prone to changes in usual care, with exacerbations playing a key role. doi.org/10.1186/s129... #asthma

Our latest study is now online in @JAMA Network Open, reporting on the limited estimative performance of exacerbation (ECOPD) history categories by GOLD. Novel cutoffs are suggested in the paper. doi:10.1001/jamanetworkopen.2024.45488

Low birth weight is associated with increased risk of COPD, but also has interactions with maternal smoking, older age and passive smoking. Low birth weight and smoking during pregnancy have a joint effect.
bmjopenrespres.bmj.com/content/11/1...

Procalcitonin-guided antibiotic therapy for patients with exacerbations of COPD significantly reduced the rate of antibiotic prescriptions without negatively affecting treatment success rate or other outcomes. doi.org/10.1016/j.cm... @cmijournal.bsky.social

Several interesting points in this figure: 1) ex-smokers with COPD are less likely to have cough or phlegm than current smokers; 2) more extensive mucus plugging is associated with lower percentage of patients without these symptoms #COPDGene journal.chestnet.org/article/S001... #chest

Framework for understanding the neurophysiologic mechanisms of dyspnea during exercise in patients with COPD journals.lww.com/co-pulmonary...

Differences in microbiome composition and macrophage function between health and COPD #ERS #ERJ #dysbiosis doi.org/10.1183/1600...

COPD is a heterogeneous complex disease resulting from complex host–environment interactions due to multiple environmental exposures over time, the host’s underlying
susceptibility and various host responses at the protein-to-cell and tissue-to-organ scales publications.ersnet.org/content/erj/...

The last revival of N-acetylcysteine (NAC) in COPD? > Long-term treatment with high-dose NAC did not reduce the annual rate of total exacerbations (or improve lung function) in patients with mild-to-moderate COPD. doi.org/10.1038/s414... @naturecomms.bsky.social

Application of ERS/ATS Spirometry Standards and Race-Neutral Equations in COPDGene

ERS/ATS criteria discriminate survival, imaging characteristics, and exacerbation rates better than GOLD stage, and highlight use of race-neutral spirometry
@atscommunity.bsky.social

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