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01.10.2025 23:13 — 👍 1 🔁 0 💬 0 📌 0
Submit an abstract by October 1 for the AACR Special Conference on Cancer Evolution (December 4-6; Albuquerque), chaired by Mariam Jamal-Hanjani, Kenneth J. Pienta, and Mara H. Sherman and held in association with #AACRCEWG.
buff.ly/meDBvm2
#AACRevol25 @marasherman.bsky.social
30.09.2025 15:44 — 👍 1 🔁 2 💬 0 📌 0
❤️❤️
17.09.2025 21:27 — 👍 1 🔁 0 💬 0 📌 0
Gerstner Sloan Kettering Graduate School of Biomedical Sciences
The Gerstner Sloan Kettering Graduate School of Biomedical Sciences offers the next generation of basic scientists a program to study the biological sciences through the lens of cancer
Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer.
bit.ly/3WUiuo1
11.09.2025 17:06 — 👍 4 🔁 4 💬 0 📌 0
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
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www.sciencedirect.com/science/arti...
03.09.2025 12:56 — 👍 64 🔁 20 💬 3 📌 0
To distract from your own stress responses (!!!), check out this awesome new study from the Commisso lab linking metabolic stress to regulation of the pancreatic tumor microenvironment! ✨
24.07.2025 19:13 — 👍 9 🔁 2 💬 0 📌 0
Where we’re going, we don’t need paylines. 😳🙈
23.07.2025 21:55 — 👍 0 🔁 0 💬 1 📌 0
the treasure trove of all sequencing datasets
Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
22.07.2025 21:58 — 👍 69 🔁 37 💬 1 📌 4
mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity
More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748
New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.
www.biorxiv.org/content/10.1...
07.07.2025 14:28 — 👍 158 🔁 66 💬 4 📌 5
Alright! Took me way too long but I’m here and trying to re-engage. The world is burning but the #BAPlab is not! Up next! In two weeks our lab twins Garima Baral and Clair Pfeffer will defend their Ph.D.s 🔬I may burst from excitement or stress, one of the two. @cancer-inst-purdue.bsky.social
01.07.2025 12:16 — 👍 10 🔁 2 💬 1 📌 0
“America First” Will Destroy U.S. Science
The U.S. government has sought to restrict immigration under the “America First” doctrine.
These policies severely harm American science by stripping it of talent and eliminating
a major driver of its...
25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.
26.05.2025 03:59 — 👍 252 🔁 55 💬 1 📌 4
Congratulations to the brilliant Boire and Pe’er labs plus all authors for this seminal study of the unique tumor immunology of the leptomeninges! ✨
14.05.2025 17:12 — 👍 6 🔁 1 💬 0 📌 0
Registration is OPEN for the next edition of The Tumour Ecosystem! 🎉
Taking place next March in Bergamo, this conference will cover the latest advances in research of the tumour microenvironment.
Learn more and register now: eacr.org/conference/t...
01.05.2025 07:02 — 👍 6 🔁 4 💬 0 📌 0
Thank you my queen!! 💜💜 Inspired by you and other leaders, we are so keen to learn more about tissue-level tumor suppression alongside our amazing pancreatic cancer research community ✨
02.05.2025 18:44 — 👍 3 🔁 1 💬 0 📌 0
Wowww! Congratulations to the unstoppable Bar-Peled lab! 🥳
27.03.2025 13:38 — 👍 1 🔁 0 💬 1 📌 0
This is very much fitting, and exciting, for my first Blusky post 🤩
Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD_AACR!! t.co/vmq8ZyQ3KV
13.03.2025 16:51 — 👍 43 🔁 7 💬 2 📌 2
YAY! Congrats Ruthie + Shouval lab!! Celebration soon on both coasts 🥳🥂
13.03.2025 18:34 — 👍 1 🔁 0 💬 0 📌 0
Congratulations - happy to highlight your fantastic science! ✨
06.03.2025 09:56 — 👍 0 🔁 0 💬 0 📌 0
Yesssssss!!!
03.03.2025 19:01 — 👍 2 🔁 0 💬 1 📌 0
01.03.2025 19:45 — 👍 14 🔁 0 💬 0 📌 0
Director, Knight Cancer Institute
Professor & Chair, Dept. of Cell, Developmental & Cancer Biology
Oregon Health & Science University, USA
Columbia PhD candidate studying viral RNA structure and degradation
Pancreatic Cancer UK Fellow | Research Associate, Cancer Research UK Cambridge Institute | PhD in Molecular Medicine
Professor of Cancer Evolution. UCL Cancer Institute. Interested in cancer genomics, bioinformatics, and somatic evolution.
https://www.ucl.ac.uk/medical-sciences/divisions/cancer/our-research/cancer-genome-evolution
Postdoctoral Fellow @crick.ac.uk
Pancreatic regeneration and cancer 🔗 peripheral nervous system.
@rutemmf (twitter)
(PI: Ilaria Malanchi)
Amateur photographer when outside the lab.
Cancer Biology, Lung Cancer, Functional Genomics
Michigan | JHSPH | YaleIBIO | MIT | yalemed
#cancerimmunology, #immunotherapy and #cancer. Tweets not reflective of my employer.
Associate Professor @UCSD| HHMI Freeman Hrabowski Scholar| Research on rhomboid proteins| Proud mom| Proud PI of a very demure & mindful lab|co-founder of BUMMP |1st Gen & Black in STEM|Associate Director Biological Sciences PhD Program
Assistant professor @ University of Cincinnati, Cancer biologist interested in signaling and metabolism, Pancreatic Cancer
Associate Professor at Oregon Health & Science University studying microbial interference in host ubiquitin signaling. Current ASM Northwest Branch President. Formerly @UWBiochemistry and @MRC_LMB.
Assistant Member in csBio at Memorial Sloan Kettering. Perturb-seq, single-cell functional genomics, and techniques for perturbing the genome.
Professor, Depts Surgery & Biomedical Sciences, Director Translational Research Institute, Cedars Sinai, LA, USA
The #BAPlab @PurdueBiolSci studying pancreatic and lung cancer, phosphatases, and cell plasticity. Posts are my own. 🏳️🌈🧑🏼🔬 she/they/Dr
Scientist studying epithelial biology, stem cells and cancer at UCL (@epicentr.bsky.social) 🫁
Scientist in the Department of Molecular Biology at UT Southwestern Medical Center. We investigate mechanisms of tumorigenesis.
https://labs.utsouthwestern.edu/odonnell-lab
Assistant Professor at Rutgers Robert Wood Johnson Medical School.
Studying cancer signaling and metabolism, with interest in cell cycle phase-specific effects
all things neuroimmunology @ VIB Center for Cancer Biology
