Jon Paczkowski🌹

@plos.org why doesn't PLOS Pathogens have a bsky account?

Structure-function studies of Vibrio cholerae quorum-sensing receptor CqsR signal recognition Author summary Quorum sensing, a form of bacterial cell-cell communication, regulates diverse developmental behaviors. This study investigates CqsR, a transmembrane receptor in Vibrio cholerae, the ga...

It is rare as an editor to get to take on an article so uniquely in your wheelhouse. Sharing some wonderful work by Guarnaccia et al. from the Perez, Ng, and Neiditch labs. #structuralbiology of #pathogens @plos.org
dx.plos.org/10.1371/jour...

Not-so-mutually beneficial coral symbiosis The partnership between corals and their intracellular algal symbionts has long been a textbook example of mutually beneficial association. In this essay, Mikhail Matz argues for an updated view in which the coral acts more as a farmer of algal cells to support its own growth.

I missed this when it came out last September - excellent essay!
Not-so-mutually beneficial coral symbiosis: Current Biology www.cell.com/current-biol...

I have an R56 that will pay for 1 year of a postdoc that will hopefully bridge us to a 4-year R01. It's not without risk but uh...everything in science feels like a major risk right now. We're in need of a #postdoc w/ #nmr experience. DM or email me for project details.

Our Pitt Microbiology and Molecular Genetics department in the School of Medicine is recruiting..

Microbiologists! 🧫🦠🔬🧪

Please apply to join our faculty and enjoy these views 👀 while doing great science

cfopitt.taleo.net/careersectio...

Whoa! I grow aster, too. King size is certainly right! Holy cow, I've never seen one so big.

What is the flower in the top left? Sunflower? Awesome color, if so!

Jon Paczkowski

neighbors induce switch
two-faced outcome toggled on
factor protected

#sciku 🧪🧬🔬🧫🦠 #Phages2025

I'll never forget the series that Bich Chonce had.

I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc

Overview of paper revealing role of arginine in regulating K. pneumoniae mucoidy.

Our paper reporting a highly conserved mechanism by which arginine positively regulates hypervirulent K. pneumoniae mucoid phenotype is now fully online.
rdcu.be/euiWG

Summary picture is below, but details in the 🧵

Disco lights

Phage DisCo! Our targeted phage discovery method in press today: journals.asm.org/doi/10.1128/...

Perfectly timed with our four summer undergrad's first successful phage hunt... disco lights in the lab to mark the occasion 🕺

www.asmcareerconnections.org/job/research...

12-month hard salary. 100% focus on research and training. Chance to join a microbiology-focused department (viral and bacterial).

The Wadsworth Center, New York State Department of Health, is currently recruiting for a Research Scientist 5 (Assistant/Associate Professor equivalent) to lead an independent research program focused on zoonotic and/or vector-borne pathogens (viral and bacterial).

Baseball, and why it's the most beautiful sport ever created.

The meme channel in our lab Slack should be re-named the PI roast channel.

#standupforscience2025

Philly is out in full force to Stand Up for Science!!

Lincoln memorial in the background with stand up for science posters in the foreground

Lincoln memorial with sound equipment

2 HOURS & 30 MINUTES TO GO!

#standupforscience2025

#StandUpForScience
Science not silence!

Sign that says "this is how the next pandemic starts."

Getting ready to #StandUpForScience in Washington, DC

Please share!

Direct cell–cell contact activates SigM to express the ESX-4 secretion system in Mycobacterium smegmatis | PNAS Conjugal cell–cell contact between strains of Mycobacterium smegmatis induces the esxUT transcript, which encodes the putative primary substrates o...

www.pnas.org/doi/10.1073/...

Intercellular communication and conjugation are mediated by ESX secretion systems in mycobacteria Sequential stimuli prompt reciprocal communication for conjugation in mycobacteria.

www.science.org/doi/10.1126/...

Research Affiliate I (Post Doctoral) Applications to be submitted by March 14, 2025 Compensation Grade: P99 (Research Affiliate I) Compensation Details: Minimum: $61,008.00 - Maximum: $61,008.00 Annually Department (OPH) WADS - Wadsworth...

Looking for a postdoctoral position in mycobacterial cell-cell contact communication? Look no further! Join my colleagues, Todd Gray and Keith Derbyshire, at the Wadsworth Center:

healthresearch.wd1.myworkdayjobs.com/en-US/HRI_Ca...

A Salmonella enterica serovar Typhimurium Genome-wide CRISPRi Screen Reveals a Role for Type 1 Fimbriae in Evasion of Antibody-Mediated Agglutination https://www.biorxiv.org/content/10.1101/2024.12.16.628777v1

Hourly Laboratory Technician I Applications to be submitted by January 06, 2025 Compensation Grade: H96 Compensation Details: Minimum: $17.85 - Maximum: $17.85 Hourly Department (OPH) WADS - Wadsworth Center Job Description: Respon...

Long shot (feel free to share), but are you or someone you know an engineering student in the Albany area looking for work? @sianowen.bsky.social and I are hiring someone to do a custom instrument build and a little microbiology with us. Part-time, hourly work that fits your schedule this semester.

Genome-wide identification of bacterial genes contributing to nucleus-forming jumbo phage infection Abstract. The Chimalliviridae family of bacteriophages (phages) form a proteinaceous nucleus-like structure during infection of their bacterial hosts. This

From Peter Fineran Lab

academic.oup.com/nar/advance-...

Very glad to see our story on the choreography of #ESCRT proteins in #archaeal cell division finally published in mBio - Junfeng Liu et al "A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon" journals.asm.org/doi/10.1128/...

Published in March, this video comes from research that aimed use #CryoET to demonstrate how FtsZ filaments are recruited into a ring or “toroidal” structure as part of a bacterial cell’s division machinery. #12DaysOfeLife
https://buff.ly/3BBCDIY