International Society of Genetic Genealogy

Targeting Fusobacterium nucleatum in colorectal cancer: therapeutic strategies and future directions There is growing evidence that Fusobacterium nucleatum, a Gram-negative anaerobic bacterium found in the gut and oropharynx, is a key player in the pathogenesis of colorectal cancer (CRC), by promoting tumor progression, immune evasion, and drug ...

“Beyond its oral pathogenicity, F. nucleatum has been linked to various systemic infections, including appendicitis, chorioamnionitis, osteomyelitis, pericarditis, and brain abscesses.” #ISOGG #DNA #epigenetics #colorectalcancer #cancer

pmc.ncbi.nlm.nih.gov/articles/PMC...

New study shows Alzheimer’s disease can be reversed to achieve full neurological recovery—not just prevented or slowed—in animal models | CWRU Newsroom | Case Western Reserve University For more than a century, people have considered Alzheimer's disease (AD) an irreversible illness. Consequently, research has focused on preventing or ...

“The pharmacological approach in this study, however, uses a pharmacologic agent (P7C3-A20) that enables cells to maintain their proper balance of #NAD+ under conditions of otherwise overwhelming stress, without elevating NAD+ to supraphysiologic levels.” #ISOGG #DNA case.edu/news/new-stu...

The changing story of the Beachy Head Woman | Natural History Museum The identity of a mysterious Roman-era skeleton found in southern England may have finally been resolved.

“By using state-of-the-art DNA techniques and newly published genomes, we were able to determine the ancestry of the Beachy Head Woman with much greater precision than before,” William reveals.” #ISOGG #DNA #AncientDNA #BeachyHeadWoman #UK www.nhm.ac.uk/discover/new...

Exclusive: Have scientists found Leonardo da Vinci’s DNA? Inside the decadeslong quest to reveal the genes of a genius—and revolutionize art authentication

“If these efforts manage to pinpoint Leonardo’s Y chromosome, its sequence would become the project’s genomic ground truth” #DNA #ISOGG #LeonardodaVinci www.science.org/content/arti...

IGG FREE KINDLE BOOK! #igg is the acronym for “Investigative Genetic Genealogy”. Use this link to get the book free on Kindle and if you don’t have a Kindle, you can read it using the Audible smartphone app.
genealogybargains.com/amazon-chest...
#FreeReads #Mystery #DNA #BookAddict #Kindle

“Our data provide a foundational resource to decode human immune function and genetic variation and for new approaches to study gene regulatory networks.” #DNA #genetics

High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia | Neurology Background and ObjectivesThe association between dairy intake and dementia risk remains uncertain, especially for dairy products with varying fat contents. The aim of this study was to investigate the...

“Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia, whereas low-fat cheese. APOE ε4 status modified the association between high-fat cheese and AD.” #ISOGG #DNA #epigenetics #cheese #brie #APOE4 #dementia www.neurology.org/doi/10.1212/...

Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm - Molecular Psychiatry Molecular Psychiatry - Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm

“We discovered 3 regions of the genome carrying distinct DNA methylation profiles in sperm from individuals with history of childhood psychological stress, notably at proximity of genes regulating the development of the central nervous system.” #ISOGG #DNA www.nature.com/articles/s41...

Mitochondrial DNA Pathogenic Variant Prevalence in Primary Mitochondrial Disease Patients With African (L) Mitochondrial Genome Haplogroups Primary mitochondrial diseases (PMD) are caused by pathogenic variants in over 350 genes, 37 of which are located in mitochondrial DNA (mtDNA). While more than 100 mtDNA variants have confirmed disease associations, there are few reports of ...

“Our finding high‐level & sub‐haplogroup contexts of causal mtDNA pathogenic variants in PMD patients proves a possible contributor, the modifying effects of haplogroup context are not a main driver of the diagnostic disparities evident for African patients.” pmc.ncbi.nlm.nih.gov/articles/PMC...

#Neanderthals #ShanidarZ #DNA #ancientdna #ISOGG #Netflix

Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide - Nature Medicine This study provides the first evidence in humans that tirzepatide modulates brain electrophysiology, with changes in low-frequency accumbens power linked to food preoccupation.

“Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," authors of the study conclude. #ISOGG #tirzepetide #epigenetics
www.nature.com/articles/s41...

Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial Carnobacterium maltaromaticum and Faecalibacterium prausnitzii induce de novo gut synthesis of vitamin D to inhibit colorectal carcinogenesis in mice.…

“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...

YouTube video by NBC News First reported death from meat allergy caused by tick bite

“Researchers have linked the death of a 47-year-old man in New Jersey to alpha-gal syndrome, which usually starts with a bite from a lone star tick. The man died four hours after eating a hamburger. NBC News’ Anne Thompson.” #ISOGG #epigenetics #AlphaGal #tick #allergy

youtu.be/Tp96QZfzNlU?...

Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation Hydrogen-rich water (HRW) is a beverage containing a high concentration of hydrogen that has been researched for its antioxidant, anti-apoptotic, and …

“Regarding the underlying mechanisms of action, it is tentatively believed that the primary intracellular target of hydrogen is the mitochondria. “…hydrogen can activate Nrf2 receptors, which can have beneficial effects on cardiovascular health and anti-aging." www.sciencedirect.com/science/arti...

Researchers issue warning after discovering unexpected link to heart failure: 'Appears to be increasing over time' This is not the first research to highlight a connection.

“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #epigenetics
www.yahoo.com/news/article...

Scientists Found a Hidden Switch in Your Brain That Could Reverse Memory Loss A new discovery shows that a protein called the ferritin light chain 1, or FTL1, plays a big role in the decline of our mental faculties as we age.

“The researchers hope that by targeting FTL1, future therapies may not only improve natural cognitive decline, but will also benefit people with neurodegenerative diseases.” #DNA #ISOGG #Alzheimers #epigentics #cognitivedecline #neutrites

www.yahoo.com/news/article...

“Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is important in supporting mitochondrial function. SF or its precursor glucoraphanin; broccoli seeds or sprouts, confers neuroprotective & cognitive benefits.” #ISOGG www.mdpi.com/2072-6643/17...

Antidepressant Fluoxetine Promotes Brain Plasticity in Key Cells, Reshaping Their Energy Systems A new study shows that the antidepressant fluoxetine does more than boost serotonin levels: it changes how brain cells manage their energy and rebuild their connections, potentially helping the brain ...

“Depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. #DNA #ISOGG #Prozac #Epigenetics
www.technologynetworks.com/neuroscience...

DNA reveals what killed Napoleon's soldiers during their disastrous retreat from Russia in 1812 A mass grave holding soldiers from Napoleon Bonaparte's French army reveals some of the diseases that killed the Grande Armée during its disastrous retreat from Russia in 1812.

“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French
news.yahoo.com/articles/dna...

“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #epigenetics #gluten #FODMAPS www.unimelb.edu.au/newsroom/new...

Interbreeding with Neanderthals may be responsible for modern-day brain condition, SFU study finds A new Simon Fraser University-led study reveals interbreeding between humans and their ancient cousins, Neanderthals, as the likely origin of a neurological condition estimated to impact up to one per...

“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #AncientDNA #epigenetics www.sfu.ca/sfunews/medi...

Exclusive | My nonverbal autistic son began speaking at age 8 after taking wonder drug — he’d understood everything for years and had complaints Nathaniel Schnier had notes — years’ worth of them.

“The pediatric neurologist was studying whether leucovorin could help autistic children with cerebral folate deficiency — or a shortage of vitamin B9 in the brain.” #DNA #ISOGG #epigenetics #autism #folate #B9 nypost.com/2025/10/14/h...

Restless Legs Treatment Slashes Increased Risk of Parkinson's Disease A condition that compels people to move their legs could indicate they have a greater chance of developing Parkinson's disease.

"Furthermore, patients with RLS who were not treated with dopamine agonists tended to be at increased risk of developing Parkinson's disease, whereas those who were treated with dopamine agonists tended to be at decreased risk compared with the control group."
www.sciencealert.com/restless-leg...

2025 East Coast Genetic Genealogy Conference - ECGGC East Coast Genetic Genealogy Conference

Registration ends 30 Sept 2025 for the virtual East Coast Genetic Genealogy Conference. You have until 31 Dec 2025 to watch all of the recordings. There’s an ISOGG presentation where we celebrated ISOGG’s 20th year, review the history and discuss future goals. #ISOGG #DNA #ECGGC ecggc.org

Century-old lungs stored in jar reveal how 1918 Spanish flu pandemic began Findings could lead to better understanding of how viruses adapt to humans during a pandemic

“Another mutation of a protein in the virus’s membrane improved its ability to bind to entry point receptors in human cells, making it more resilient and infectious.” #isogg #DNA #epigentics #1918Flu #SpanishFlu
www.the-independent.com/news/science...

Cycling linked with lower dementia risk, study finds | CNN Cycling instead of driving has been linked with a lower risk of dementia and Alzheimer’s disease, a large study has found.

“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...

New Breakthrough to Strengthen Bones Could Reverse Osteoporosis A new study points to a key bone-strengthening mechanism at work in the body, which could be targeted to treat the bone-weakening disease, osteoporosis.

New finding on #osteoporosis: “Researchers from the University of Leipzig in Germany and Shandong University in China, identified the cell receptor GPR133 (also known as ADGRD1) as being crucial to bone density, via bone-building cells called osteoblasts.” www.sciencealert.com/new-breakthr...

East Coast Genetic Genealogy Conference 2025: My Experience Explore my review of the East Coast Genetic Genealogy Conference 2025, featuring insights, sessions, and a virtual learning experience.

Nice blog post by Linda Yip on the East Coast Genetic Genealogy Conference which you can STILL sign up to watch the recordings through Dec 31, 2025. Registration ends Sept 30,2025 so don’t procrastinate on registering. #geneticgenealogy #ISOGG #DNA #ECGGC
past-presence.com/2025/09/14/k...

“The authors identified a class of lithium compounds that can evade capture by amyloid beta. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer’s disease pathology, prevented brain cell damage, and restored memory.”
hms.harvard.edu/news/could-l...

Genomic diversity and structure of prehistoric alpine individuals from the Tyrolean Iceman’s territory - Nature Communications Here, the authors perform genomic analysis of prehistoric individuals from the Italian Alps, to reveal a genetic shift from the Mesolithic to the Neolithic and genetic continuity from the Neolithic to...

"Moreover, G2a2* is represented by only one sub-lineage (G2a2b2a1a1b*, L497) except for the Iceman, which carries a different one (G2a2a1a2a1a1b, G-Z6208, or formerly G2a2a1a2 L-91"
#DNA #ISOGG #YHaplogroupG #AncientDNA #Iceman

www.nature.com/articles/s41...