Ryan M. Pearson, PhD.

A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. He...

COMMENT | ‪🧪

@colbyvorland.bsky.social ‬, L Golzarri-Arroyo & DB Allison (Indiana Uni)

This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses.

www.nature.com/articles/s42...

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

RESEARCH | MH Tschöp, TD Müller et al

@www.helmholtz-munich.de

Part 2: This study and a co-pub delve into how both #GIPreceptor #agonists and #antagonists trigger weight loss through different mechanisms.

🧪

www.nature.com/articles/s42...

Excited to be co-chairing a fantastic Immuno Delivery session at the CRS this Wednesday alongside Helena Florindo!

We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu

Nanoneedles enable spatiotemporal lipidomics of living tissues - Nature Nanotechnology Arrays of silicon nanoneedles are used to generate molecular replicas of live brain tissue for longitudinal spatial lipidomic classification via desorption electrospray ionization mass spectrometry imaging of gliomas and to monitor the responses of the tumours to chemotherapy.

A paper in Nature Nanotechnology presents a method using arrays of silicon nanoneedles to generate molecular replicas of living tissue, enabling mapping for glioma characterization and classification. The method allows for the monitoring of the response of the tumours to chemotherapy. #medsky 🧪

#Fumarate update

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation

Dual role in Inflammation

Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10

Pro-
mtDNA mtRNA➡️IFNβ

#CellMetab 2025
www.sciencedirect.com/science/arti...

I'm thrilled to share that our lab has been awarded an R01 from NIH NIAID to continue our research to develop new nanoparticle-based immunotherapies for treating sepsis! news.pharmacy.umaryland.edu/umsop-facult...

Similarities in B Cell Defects between Aging and Obesity Abstract. The aging population is increasing worldwide, and there is also an increase in the aging population living with overweight and obesity, due to ch

Dr. Daniela Frasca et al highlight the interesting role of metabolism in #aging by comparing age and obesity in humans. They note that aging and obesity are conditions which can lead to dysregulated immune responses. Learn more: ow.ly/MeGI50W6fLn

Tutorial: guidelines for the use of machine learning methods to mine genomes and proteomes for antibiotic discovery - Nature Protocols In this Tutorial, we provide guidelines for the use of ML models to mine genomes and proteomes for the discovery of antimicrobial peptides, discussing the various stages of the ML workflow, recent advances in ML models and how to experimentally validate the computational predictions.

A Tutorial in Nature Protocols provides guidelines for the use of machine learning models to mine genomes and proteomes for the discovery of antimicrobial peptides. 🔒

Congratulations!!!

Signalling from adipose tissue to the brain is not just about leptin - Nature Metabolism A Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.

NEWS&VIEWS | Peter Arner ( ‪@ki.se‬ )

Under acute stress, adipose tissue lipolysis causes release of GDF15 from local macrophages, which binds to GFRAL in the brain, evoking anxiety.

I am excited to share that we are hiring for up to 3 postdoctoral fellow positions! Please see ad.
(1) Translational Immunology Fellow
(2) En Route Care Fellow
(3) Polymer Chemistry and Drug Delivery Fellow
Reach out if you have any questions. Application review will begin immediately.

We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And the leads to a unified model to put it all together. (open-access)
erictopol.substack.com/p/the-driver...

Macrophages: sentinels, warriors, and healers Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur

Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008

academic.oup.com/hmg/advance-...

ACOD1 regulates microglial arginine metabolism and inflammatory responses https://www.biorxiv.org/content/10.1101/2025.06.01.657243v1

Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy Rodriguez et al. investigate the impact of biased signaling with a dual GLP-1R/GIPR agonist. Biased GLP-1R and GIPR agonism leads to better and prolonged glucose lowering, greater food intake reductio...

Why is the dual receptor agonist tirzepatide (Mounjaro, Zepbound) more potent than semaglutide (Ozempic, single receptor, GLP-1 agonist)?
www.cell.com/cell-reports...

Quick Take: Oral Semaglutide and Cardiovascular Outcomes

Injectable semaglutide reduces the risk of major adverse cardiovascular events in persons with type 2 diabetes and high cardiovascular risk. Research findings from the SOUL trial with oral semaglutide are summarized in a new Quick Take video. nej.md/3Ze59cr

#MedSky #CardioSky

Can we improve immune health by restoring microbial biodiversity? - Nature Reviews Immunology Diverse microbial exposures in early life reduce the risk of inflammatory conditions, including allergies and autoimmunity. Emerging data suggest that microbial diversity is as important as microbial ...

A way to improve a person's immune system response is through the diversity of their microbiome
www.nature.com/articles/s41...

Biology-driven material design for ischaemic stroke repair - Nature Reviews Bioengineering Rehabilitation after ischaemic stroke can promote only limited recovery for many patients with stroke. This Review discusses how the distinctly reparative environment of the subacute time window after stroke can inform the design of biology-driven biomaterial-based stroke therapies.

Ischaemic stroke remains a leading cause of disability. This article discusses the design of biomaterials that can engage and modulate pro-repair mechanisms in the brain to improve repair after ischaemic stroke:

Lipid nanoparticles from L. meyenii Walp mitigate sepsis through multimodal protein corona formation Plant-derived lipid nanoparticles (PDNPs) are nano-sized particles isolated from various edible plants that contain bioactive components involved in r…

🌿💥 New from our lab: Plant-derived lipid nanoparticles from Lepidium meyenii (maca) show potent protection against sepsis by forming a multimodal protein corona that soaks up inflammatory biomolecules, reducing organ damage and boosting survival. @cellpress.bsky.social Link: tinyurl.com/ucfjebtm

Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer’s disease - Nature Aging Heo, Xu et al. used comprehensive plasma proteomics to identify 416 plasma proteins (294 new) associated with Alzheimer’s disease and applied machine learning to select 7 proteins that were highly pre...

Our ability to accurately predict #Alzheimer's disease years in advance of any symptoms keeps getting better with plasma proteins and A.I. analytics @nataging.nature.com
www.nature.com/articles/s43...

T cell memory alters pulmonary inflammatory responses to cecal ligation and puncture. https://www.biorxiv.org/content/10.1101/2025.05.15.654338v1

Analysis of multi-drug cancer nanomedicine - Nature Nanotechnology Multi-drug nanotherapy consistently outperforms single-drug therapy, multi-drug combination therapy, and single-drug nanotherapy across different experimental settings, therapy strategies and cancer t...

New paper online: Analysis of multi-drug cancer nanomedicine.

Multi-drug #nanomedicine consistently outperforms single-drug therapy, multi-drug combination therapy, & single-drug nanotherapy across different experimental settings, strategies, and #cancer types.

www.nature.com/articles/s41...

Discovering nanoparticle corona ligands for liver macrophage capture - Nature Nanotechnology Liver macrophages are a major obstacle to extrahepatic drug delivery. This study identifies the receptor–ligand interactions that they use to capture circulating nanoparticles and leverages this under...

New paper online:

Discovering nanoparticle corona ligands for liver macrophage capture.

The study identifies receptor-ligand interactions that #macrophages use to capture circulating #nanoparticles and leverages them to engineer nanoparticles that escape uptake.

www.nature.com/articles/s41...

A neuroimmune pathway drives bacterial infection Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.

A new #ScienceAdvances study identifies a neuroimmune pathway for treating sepsis, finding that dopamine inhibits expression of a critical regulator of immunometabolism.

This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ

Mobile integrons encode phage defense systems Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...

#NatureMicroPicks

Microbial integrons in focus 🦠🧬

Two studies showing microbial integrons encoding phage defense systems

#MicroSky

www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Discovering a natural brake to inflammation!

WanJun Chen & team reveal the Activin A/Smad3 axis protects mice from inflammation in models of sepsis and psoriasis and is active in humans: buff.ly/Gt8xW0v

This is figure 6, which shows the shared signatures of plasma proteome dysregulation associated with respiratory symptoms in healthy convalescent individuals and individuals with long COVID.

A study in Nature Immunology explores soluble biomarkers, immune cell subsets, viral antibody responses and plasma proteomics to better define and understand long COVID in two independent cohorts. go.nature.com/3GVktnC #medsky 🧪