Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation In novel environments, animals quickly learn to navigate, and position-correlated spatial representations rapidly emerge in both the retrosplenial cortex (RSC) and primary visual cortex (V1). However,...

How does the brain balance learning new things without overwriting what it already knows? Our new paper tackles this long-standing stability–plasticity dilemma during active navigation. With Tony Drinnenberg from the Deisseroth Lab (@deisseroth.bsky.social)
doi.org/10.1101/2025...

Postdoctoral Research Fellowship (286516) | University of Oslo Job title: Postdoctoral Research Fellowship (286516), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025

Please RT
2 new positions in the lab as postdoc & PhD!

Interested in stress, pain, or reward? This project has it all!

We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶

www.jobbnorge.no/en/available...

Branch logic: Dendritic computations diversify inhibition Long known for different circuit roles, parvalbumin and somatostatin interneurons are shown by Morabito et al.,1 in this issue of Neuron, to differ in…

🧪 We got the privilege to write a Preview on the beautiful work of Morabito, Zerlaut, Rebola and colleagues that was recently published in Neuron. www.sciencedirect.com/science/arti...

Ripple contributions to human memory: making the spiking content count - Nature Reviews Neuroscience In animal models, transient high-frequency oscillations in synchronized neural activity, known as ripples, have been linked to memory. Reithler et al. assess the current evidence for a contribution of...

Ripple contributions to human memory: making the spiking content count — a Review by Joel Reithler, Kelsey K. Sundby & Kareem A. Zaghloul

www.nature.com/articles/s41...

#neuroscience #neuroskyence

Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain Thalamocortical projections contribute to the spatial organization and functional hierarchies of the mammalian cortex. Primary sensory cortices receive topographically segregated information from firs...

Check out this exciting study led by Anh-Tuan Trinh from our lab, where we investigated how thalamocortical-like circuits in the zebrafish pallium receive, represent, and integrate sensory information:
🔗 doi.org/10.1101/2025...

Human intelligence is overrated and not a useful yardstick for AI - a polemic. markusmeister.com/2025/09/15/w...

A neural manifold view of the brain Nature Neuroscience - Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds....

This type of textbook chapter review of neural manifolds has been so needed. Thank you for writing this. It's excellent.

rdcu.be/eGjAu

Our first steps into sensory processing is now online!
Work spearheaded by Rejwan Salih from experiments by @prime5222.bsky.social and François Pauzin
We were lucky to receive guidance from Davide Zoccolan on the analytical methods.
#neuroskyence

Phd candidate or postdoc– Genetic determinants of opioid responsiveness The Department of Research and Development at the Division of Emergencies and Critical Care, Oslo University Hospital in collaboration with Leknes Affective Brain lab (www.affectivebrains.com) and the...

What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans?

Fully funded position in Oslo (PhD student or postdoc)

Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...

Please RT for reach

This comment is 3 minutes long, and it's from back in February. It bears repeating.

"Curiosity-driven, peer-reviewed research is not meant to pass the politician's test."

x.com/RepAuchinclo... (1/2)

Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.

www.biorxiv.org/content/10.1...

Diatoms?

A piece of neuroscience history. The original "Oslo chamber", possibly the first one to be used for holding brain slices.

Has anyone got any experience with gcamp8 transgenic mice yet? Eg the Thy1-GCaMP8s line?

janelia.figshare.com/articles/dat...

Direct entorhinal control of CA1 temporal coding Nature Communications - Temporal coding in the hippocampus is thought to be key for memory and predictions. Here, the authors show that blocking one entorhinal input affects two aspects of...

Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in @natcomms.nature.com 🔬🧠

rdcu.be/evWtz

Congrats!

Opening new neuroscience horizons:
With this tool, we can study dendritic computation and network dynamics under naturalistic behavior: an essential step toward understanding the neural basis of cognition. 🌍🧠

Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a c

These insights enable stimulation “tuning” to target specific functions. This work also highlights how flicker stimulation has multiple biological effects and we think such a multipotent therapeutic approach is required for neurodegenerative diseases. This study was made possible by Levi Wood’s lab

Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function ...

Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal | Science www.science.org/doi/10.1126/...

Does Anybody Really Know What Time Is? Yes, your brain does. It created it.

Physicists have a lot to say about time, but so do neuroscientists -- after all, it's the brain which in some sense creates time, and enables our remarkable capacity for "mental time travel." I spoke with neuroscientist @deanbuono.bsky.social for @nautil.us:
nautil.us/does-anybody... #science

We started that, but rabies tracing requires trying multiple strains because there seems to be some cell type selectivity. That takes a lot of time and therefore we couldn’t honor this request.

Distinct dendritic integration strategies control dynamics of inhibition in the neocortex Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…

📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!

www.sciencedirect.com/science/arti...

Nice to see it out! Congrats. Also fits with our work in Kriener et al. Where we patched PV basket cell dendrites in the dentate gyrus and found sublinear integration.

Brain region-specific gain modulation of place cells by VIP neurons - Nature Communications Functional roles of interneurons in regulating the gain of place-tuned neurons are not fully understood. Here, the authors show that VIP neurons fine-tune brain circuits like amplifiers in electronics...

Thanks for highlighting our preprint. Here is another Recently published VIP cell paper: www.nature.com/articles/s41...

Brain region-specific gain modulation of place cells by VIP neurons Nature Communications - Functional roles of interneurons in regulating the gain of place-tuned neurons are not fully understood. Here, the authors show that VIP neurons fine-tune brain circuits...

rdcu.be/euiTe

New blog post with a review of interesting papers on VIP interneurons in cortex and hippocampus: gcamp6f.com/2025/06/23/i...
Covering work from @koenvervaeke.bsky.social's lab with @mateneubrandt.bsky.social, Yoav Adam's lab and Bernardo Rudy's lab.

Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex - Nature Neuroscience Using a spatial reasoning task in mice, the authors show that retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming inf...

Mouse retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming information to resolve ambiguities

@jvoigts.bsky.social

www.nature.com/articles/s41...

The gamma rhythm as a guardian of brain health Fast oscillations (30-150Hz), generated by internal brain mechanisms may be essential for the maintenance of healthy brain function.

Whether gamma stimulation is a silver bullet for Alzheimer’s remains to be seen. But it boosts glymphatic flow, immune signaling, and engages inhibitory neurons like VIP cells. Understanding the mechanisms could unlock its full potential.
elifesciences.org/articles/100...

Area-specific encoding of temporal information in the neocortex The retrosplenial cortex (RSC) is a brain region associated with episodic memory. Garvert et al. show that time-encoding cells are present in the RSC but rare in nearby neocortical areas. These findin...

We found time cells in the retrosplenial cortex—but not in neighboring areas. A new piece in the puzzle of how the brain keeps track of time.

www.cell.com/cell-reports...

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

Our new paper is out in Science.

What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.

Congrats Jake!

www.science.org/doi/10.1126/...