SheinerLab

Thank you Philippe, I had an excellent and inspiring day!!

If you are a committed scientist who wishes to work with Toxoplasma or with organelles (or both!!) - come work with us:
www.jobs.gla.ac.uk/job/research...

Complexome profile of mitochondrial complexes in the myzozoan parasite of oysters, Perkinsus marinus Mitochondrial complexes, such as the mitochondrial electron transport chain (mETC), the F1Fo-ATP synthase and the mitochondrial ribosome, are centrally important for mitochondrial function. Recently, ...

Perkinsus marinus is an important marine pathogen yet we know little about its biology.

@macleanlab.bsky.social reports here complexome work of whole parasite and mitochondria mapping the essential mitochondrial enzymes and kickstarting future functional studies.
www.biorxiv.org/content/10.6...

YouTube video by Protistologists ISOP member spotlight Lilach Sheiner

Had a great time interviewing Dr. Lilach Sheiner (@sheinerlab.bsky.social) for the latest edition of ISOP’s Protistology Newsletter. Check it out here! #ProtistsOnSky #Toxoplasma #Science

Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...

EastBio: A host-directed approach to identify novel therapeutic targets of infectious reproductive diseases at Moredun Research Institute on FindAPhD.com PhD Project - EastBio: A host-directed approach to identify novel therapeutic targets of infectious reproductive diseases at Moredun Research Institute, listed on FindAPhD.com

🎓 Funded #PhD studentships in pathogen biology and parasitology

*Cell and Molecular Biology*; *Host-pathogen interactions*

Part of the EastBio Doctoral Landscape Award

Based in the Edinburgh area of Scotland

PhD 1:
bit.ly/Host-pathoge...

PhD 2:
bit.ly/Parasite-sca...

@uoe-eid.bsky.social

and meet the @sppirit-network.bsky.social dream team that made it all happen! Follow the for more (a new #Postdoc fellowship workshop coming up!!)

Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications.

Join us at 12 noon on Thursday 14th November!

Register at docs.google.com/forms/d/e/1F...

Busy and exciting poster session @sppirit-network.bsky.social conference. SheinerLab's Anil and Victor spotted checking out some cool work!

Jana getting everyone into #membranes at @sppirit-network.bsky.social conference.

An official new measuring unit for the parasitology community had emerged from this @parafrap.bsky.social #EMBO conference... #shitton @nicolas3474.bsky.social
@kirkdeitsch.bsky.social

Fabulous work from @nicolas3474.bsky.social on the protein atlas of the molluscs parasite #Perkinsus @parafrap.bsky.social

Wonderful session on @parafrap.bsky.social parasites pathogenesis chaired by @apicolipid.bsky.social @clarehardinglab.bsky.social

The science at #ParaFrap is exciting and surprising as always - less surprising: who are the last people standing on night #1 ... @freddyfrischknecht.bsky.social @kirkdeitsch.bsky.social

Kick-off of @parafrap.bsky.social #EMBO conference at #LesEmbiez by the wonderful organisers @gloverlab.bsky.social and Benoit Gamain who put together an exciting program about parasite biology, epidemiology and combat.

We have a project advertised as part of the @NorthWestBio1 program this year - come join us!

www.gla.ac.uk/postgraduate...

Applications to the program are here:
www.gla.ac.uk/postgraduate...

Congratulations Saniya for graduating her PhD!!!

Calling all mitochondria enthusiasts, we are recruiting for a new project (and the post will be split between Glasgow and Helsinki)

www.jobs.gla.ac.uk/job/research...

Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...

The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion.
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...

Our session explored how studying bioenergetics enzymes via structural biology in divergent protist sheds light on the role of these enzymes and their assemblies across eukaryotes and on how they function in the context of each organisms’ specialised needs.

Team bioenergetics in divergent organisms is ready to go! #ICOP25 @macleanlab.bsky.social @lettsscience.bsky.social

@fad1.bsky.social showing us how gene drives will end malaria!!

A first #ICOP25 day 2 highlight: Dayana Salas-Leiva of Ross Waller's lab uses LOPIT to ask not only what makes a symbiotic relationship, but what baggage is left after a break-up. Stay tuned!

Some great models used to study endosymbiosis and what does it take to make a stable relationship:

Julius Lukes LOPIT of Insect Trypanosomes reveals new host-endosymbiont interactions

Ellen Yeh Epithemia diatoms probes the underlying mechanisms of establishing endosymbiosis

First - a vivid discussion about determining the origin and early evolution of eukaryotes following Andrew Roger's talk.

#ICOP25 opened today with so many exciting eukaryotic microbe insights 🦠 - you know its gonna be a great one when it starts with a drown video 😉 Stay tuned!!

Happy to have contributed to this wonderful study about #Toxoplasma #supercomplex led by @macleanlab.bsky.social, @sheinerlab.bsky.social and Alex Mühleip. Parasite mitochondria never cease to amaze! Please go checkout 👇

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.

www.nature.com/articles/s41...

Other complex III inhibitors are being developed as drug leads for apicomplexan diseases.
Together with Stone Doggett and colleagues at @OHSUNewswe we showed how the drug-lead ELQ-300 binds Toxoplasma complex III and designed a more potent version.

Atovaquone is a clinically used drug for apicomplexan diseases such as #malaria and #toxoplasmosis, but its precise mechanism of inhibition was unknown.
We showed how atovaquone interacts with Toxoplasma complex III and why it is selective to apicomplexan compared to human.