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SheinerLab

@sheinerlab.bsky.social

Research lab interested in #parasites #apicomplexa #toxoplasma #toxoplasmosis #plasmodium #malaria #mitochondria #cell-biology https://lilachsheiner.wixsite.com/sheinerlab-wtcmp

245 Followers  |  78 Following  |  49 Posts  |  Joined: 15.12.2024  |  2.077

Latest posts by sheinerlab.bsky.social on Bluesky

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An official new measuring unit for the parasitology community had emerged from this @parafrap.bsky.social #EMBO conference... #shitton @nicolas3474.bsky.social
@kirkdeitsch.bsky.social

07.10.2025 10:05 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Fabulous work from @nicolas3474.bsky.social on the protein atlas of the molluscs parasite #Perkinsus @parafrap.bsky.social

06.10.2025 17:50 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Wonderful session on @parafrap.bsky.social parasites pathogenesis chaired by @apicolipid.bsky.social @clarehardinglab.bsky.social

06.10.2025 10:59 β€” πŸ‘ 8    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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The science at #ParaFrap is exciting and surprising as always - less surprising: who are the last people standing on night #1 ... @freddyfrischknecht.bsky.social @kirkdeitsch.bsky.social

06.10.2025 10:54 β€” πŸ‘ 13    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Kick-off of @parafrap.bsky.social #EMBO conference at #LesEmbiez by the wonderful organisers @gloverlab.bsky.social and Benoit Gamain who put together an exciting program about parasite biology, epidemiology and combat.

06.10.2025 10:48 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Lilach Sheiner

We have a project advertised as part of the @NorthWestBio1 program this year - come join us!

www.gla.ac.uk/postgraduate...

Applications to the program are here:
www.gla.ac.uk/postgraduate...

30.09.2025 21:00 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Congratulations Saniya for graduating her PhD!!!

25.09.2025 15:30 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Research Associate Job PurposeThe purpose of this role is to carry out cutting-edge research to understand the structure and function of complexes essential for organelle biology and function in the apicomplexan para...

Calling all mitochondria enthusiasts, we are recruiting for a new project (and the post will be split between Glasgow and Helsinki)

www.jobs.gla.ac.uk/job/research...

18.09.2025 01:20 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1
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Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...

The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion.
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...

10.09.2025 06:57 β€” πŸ‘ 10    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Our session explored how studying bioenergetics enzymes via structural biology in divergent protist sheds light on the role of these enzymes and their assemblies across eukaryotes and on how they function in the context of each organisms’ specialised needs.

26.06.2025 04:53 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Team bioenergetics in divergent organisms is ready to go! #ICOP25 @macleanlab.bsky.social @lettsscience.bsky.social

24.06.2025 22:40 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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@fad1.bsky.social showing us how gene drives will end malaria!!

24.06.2025 06:00 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A first #ICOP25 day 2 highlight: Dayana Salas-Leiva of Ross Waller's lab uses LOPIT to ask not only what makes a symbiotic relationship, but what baggage is left after a break-up. Stay tuned!

24.06.2025 02:37 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Some great models used to study endosymbiosis and what does it take to make a stable relationship:

Julius Lukes LOPIT of Insect Trypanosomes reveals new host-endosymbiont interactions

Ellen Yeh Epithemia diatoms probes the underlying mechanisms of establishing endosymbiosis

23.06.2025 07:29 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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First - a vivid discussion about determining the origin and early evolution of eukaryotes following Andrew Roger's talk.

23.06.2025 02:43 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#ICOP25 opened today with so many exciting eukaryotic microbe insights 🦠 - you know its gonna be a great one when it starts with a drown video πŸ˜‰ Stay tuned!!

23.06.2025 02:37 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 3    πŸ“Œ 0

Happy to have contributed to this wonderful study about #Toxoplasma #supercomplex led by @macleanlab.bsky.social, @sheinerlab.bsky.social and Alex MΓΌhleip. Parasite mitochondria never cease to amaze! Please go checkout πŸ‘‡

19.05.2025 10:35 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander MΓΌhleip’s new group.

www.nature.com/articles/s41...

19.05.2025 10:22 β€” πŸ‘ 37    πŸ” 12    πŸ’¬ 4    πŸ“Œ 3
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Other complex III inhibitors are being developed as drug leads for apicomplexan diseases.
Together with Stone Doggett and colleagues at @OHSUNewswe we showed how the drug-lead ELQ-300 binds Toxoplasma complex III and designed a more potent version.

19.05.2025 13:00 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Atovaquone is a clinically used drug for apicomplexan diseases such as #malaria and #toxoplasmosis, but its precise mechanism of inhibition was unknown.
We showed how atovaquone interacts with Toxoplasma complex III and why it is selective to apicomplexan compared to human.

19.05.2025 12:58 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Respiratory complexes form β€œsuper-complexes” whose physiological function is debated, and assembly only studied in a few organisms.
We showed that apicomplexan conserved proteins mediate III2-IV supercomplex formation, and that this provides competitive growth advantage.

19.05.2025 12:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)!

But how do the parasite complexes work and how do drugs inhibit them?

Read Andrew Maclean and Alex MΓΌhleip phenomenal work on this! πŸ‘‡

19.05.2025 12:56 β€” πŸ‘ 14    πŸ” 6    πŸ’¬ 3    πŸ“Œ 0
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Inspirational talk from Dr Sharifa Abdulla about how to strike partnerships - think:
What is the problem
Whose problem is it (and therefore)
Who should be engaged in the partnership

25.04.2025 10:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Excellent to take part in a round table focus on African partnerships within our Glasgow Changing Futures strategy
@uofgsii.bsky.social @uofglasgow.bsky.social

25.04.2025 08:47 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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As Sheinerlab is joining the trend, Chat seem to have known that @macleanlab.bsky.social started his own lab recently and took the executive decision to remove him from the photo πŸ˜²πŸ˜†

31.03.2025 12:03 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

We will inform the hotel you liked it πŸ˜‰
Thank you so much for visiting us it was a great treat as always!

29.03.2025 14:11 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

A true honour. Thank you to BSP @bspparasitology.bsky.social and our fabulous parasitology community

18.03.2025 13:14 β€” πŸ‘ 18    πŸ” 2    πŸ’¬ 2    πŸ“Œ 0
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Interested in how genomics, transcriptomics & more shape infectious disease research?

Join the @lshtm.bsky.social Infectious Disease -Omics short course starting 17 June 2024 to explore cutting-edge techniques & their real-world applications!

Apply now πŸ‘‰ bit.ly/4kJOoPo

17.03.2025 15:45 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University on FindAPhD.com PhD Project - Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University, listed on FindAPhD.com

Funded PhD project with myself, Prof. Paul Denny at Durham University and Dr Kalesh Karunakaran at Teeside University now open for applications!

www.findaphd.com/phds/project...

17.03.2025 10:50 β€” πŸ‘ 8    πŸ” 7    πŸ’¬ 0    πŸ“Œ 2
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If you are interested in antigenic variation, you may have wondered how parasites β€˜select’ which antigen to express next.

Our manuscript, just published in Nature, provides some answers!

www.nature.com/articles/s41...

@lmumuenchen.bsky.social
@erc.europa.eu a.eu
@nature.com

12.03.2025 16:31 β€” πŸ‘ 37    πŸ” 12    πŸ’¬ 2    πŸ“Œ 2

@sheinerlab is following 20 prominent accounts