www.MitoWorld.org

The energy resistance principle: a new framework for understanding life - MitoWorld The energy resistance principle (ERP) describes behavior and transformation of energy in the carbon-based circuitry of biology. We show how energy resistance (éR) is the fundamental property that enab...

What if life runs like an electrical circuit?

Drs. Picard & Murugan’s “Energy Resistance Principle” (via MitoWorld’s Dane Wolf) proposes that our health depends on keeping energy flow in balance — a “goldilocks zone” of resistance powering every cell.

mitoworld.org/the-energy-r...

Link to symposium registration docs.google.com/forms/d/e/1F...

ATTENTION: Mitochondria Psychobiology, Stress & Health Symposium - MitoWorld It’s time for a science of health, and a good look at the science behind the healing process. It looks likely that mitochondria play a central role in our ability to heal and be resilient. – Martin Pi...

Our interview with @martinpicardenergy.bsky.social on MitoWorld’s MitoBlog is live!

Martin tells us about MiSBIE, how it came about, what it is and who should attend the 2025 MiSBIE Symposium

mitoworld.org/attention-mi...

MiSBIE Symposium Attendance - December 2025 Please indicate your attendance at the MiSBIE Symposium & Reception December 12 2025 CUIMC - The Roy and Diana Vagelos Education Center - 104 Haven Avenue - New York ...

It’s not too late to register and attend the Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium.

Register below for the in-person or virtual day-long session at the Picard Lab at Columbia University.

docs.google.com/forms/d/e/1F...

Moving from Rhetorical and Evidentiary Stances to Tracking the Research - MitoWorld A Divided Community In a September 2025 Viewpoint published in Nature Metabolism entitled “Mitochondria Transfer,” the editors noted, “. . . the topic continues to be met with skepticism.” As a result...

Mitochondrial Transfer & Transplantation:

Is it real?

How will we know?

mitoworld.org/moving-from-...

Mitochondrial Signaling as the New “Powerhouse of the Cell” - MitoWorld A collective effort across the mitochondrial research and clinical communities has sought to play down the “powerhouse of the cell” phrase as the sole description of mitochondria and, instead, to elev...

In the lead-up, we spoke with José Antonio Enríquez (CNIC, Madrid) about mitochondrial signaling and its growing impact on physiology.

A fascinating perspective ahead of the meeting:
mitoworld.org/mitochondria...

Looking ahead to the Keystone Symposia on Mitochondrial Signaling in Physiology and Disease (Feb 9–12, Colorado) - a major event highlighting the importance of signaling in health and disease.

Mitochondria take center stage!

www.keystonesymposia.org/conferences/...

The core information resources on the site include a directory of leading mitochondrial researchers, academic institutions, clinical centers. We invite inquiries, and we are always looking for collaborators and supporters.

§ MitoNews. We post articles from outside sources and feature mitochondria newsfeeds from PubMed, Nature Portfolio, PRNewswire and Google on our homepage.

§ “Beyond the Disease”. In partnership with the United Mitochondrial Disease Foundation (www.UMDF.org), we compile a monthly set of papers to be published in their newsletter.

§ MitoCast. We conduct video interviews and accumulate information from leading researchers and clinicians.

§ MitoBlog. We post on the latest research papers, profile mitochondrial researchers and clinicians, portray mitochondria labs globally, and report on major conferences.

Guided by a senior scientific advisory board and several mitochondrial medicine clinicians, MitoWorld’s mostly volunteer team produces the following media.

#MitoWorld is committed to raising public, professional and patient community awareness globally about mitochondria science, diseases, dysfunction and health. As a central resource, MitoWorld strives to share advances in mitochondrial research and clinical practice.

MitoWorld Supports Mitochondrial Disease Week

Home Leigh syndrome (sometimes called Leigh’s disease) is a rare and severe neurometabolic disorder and a type of primary mitochondrial disease.

Leigh Syndrome Research Retreat and Workshop of
the Cure Mito Foundation is accepting proposals from researchers and medical professionals interested in participating in a 2-day in-person retreat and workshop to advance research and treatment strategies for Leigh syndrome. lnkd.in/e62nYUHm

Mechanisms of Mitochondrial DNA Mutation and Repair - MitoWorld If our website is MitoWorld, the Mechanisms of Mitochondrial DNA Mutation and Repair conference was the introductory gathering of what could be called “mtDNA World.” The organizers, Patrick Chinnery (...

The first-ever conference dedicated entirely to mitochondrial DNA just wrapped up in Nashville!

From mutation mechanisms to repair strategies and cutting-edge editing techniques, it was a landmark event.

See the full recap 👇

mitoworld.org/mechanisms-o...

Special Issue: Cell Biology of Mitochondria - MitoWorld The special issue of Journal of Cell Science (JCS) on the “Cell Biology of Mitochondria” looks to be one of the most comprehensive open series of papers, opinions, perspectives, interviews, reviews an...

A must-read for anyone in mitochondria research!

Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!

View our summary mitoworld.org/special-issu...

Mitochondria Are More Than Powerhouses — They’re the Motherboard of the Cell - MitoWorld Columbia University mitochondria researcher Martin Picard’s life changed in 2014 when he peered through a microscope in Douglas Wallace’s lab at the Children’s Hospital Philadelphia. He saw something ...

Scientific American has a new (open) article by Columbia’s Martin Picard, comparing mitochondria to microprocessors.

It follows landmark pieces from July 1957 (“Powerhouse of the Cell”) and Aug 1997 (Wallace on mtDNA in aging & disease).

Read our summary:
mitoworld.org/mitochondria...

Identifying Mitochondrial Mutations - MitoWorld Next-generation sequencing has become the method of choice diagnosing diseases and risks, but the size difference between the nuclear and mitochondrial genomes complicates its value for mitochondrial ...

Read more - mitoworld.org/identifying-...

Has unlocking the genetic secrets behind mitochondrial diseases just got easier?

MitoPhen - is a database that brings together genotype-phenotype information and mitochondrial DNA variant levels to reveal rare mitochondrial diseases in patients not suspected of those disease

Hsu et al, ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression https://pubmed.ncbi.nlm.nih.gov/40355545/

Here it is, a new collection of papers related to #mitochondrialdisease! 📚

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social

ALDH4A1 functions as an active component of the MPC complex

Treating Mitochondria to Slow Aging? - MitoWorld The laboratory of Dr. Jennifer Trowbridge at The Jackson Laboratory published a paper that describes how a genetic mutation that alters the function of mitochondria may provide a target for slowing ag...

Could targeting mitochondria be the key to slowing aging?

We spoke to Dr Jennifer Trowbridge at The Jackson Laboratory who reveals that tweaking mitochondrial activity in blood stem cells may help prevent age-related diseases.

Read more below:

The Great Mitochondrial Replacement - MitoWorld Cytotoxic T cells are vital for eliminating cancer cells and thus for restraining tumour growth. However, many types of cancer cell blunt this immune attack by issuing signals that somehow cripple the...

Can cancer hijack your immune system - #mitochondria first?

New research reveals a striking mechanism of immune evasion: cancer cells can transfer defective mitochondria into cytotoxic T cells, impairing their energy production and killing ability.

mitoworld.org/the-great-mi...

YouTube video by MitochondriaWorld™ MitoCast: Craig Thompson

New research from Dr Craig Thompson reveals that mitochondria do more than generate energy - they form specialized subpopulations under stress, playing a key role in cancer cell survival.

Will this discovery could reshape our understanding of metabolism and disease treatment?

Thanks for sharing!

Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

#mitochondrialdisease research from last week!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social @mitowomen.bsky.social

Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

Thank you, Catalina!

We want to follow everyone working with #mitochondria!

Leave a like if you think we should follow you, or tag your colleagues and workmates in the comments below!

We've partnered with UMDF!

To kick off our collaboration, we're pleased to announce the launch of "BeyondTheDisease".

Each month, we will recap the latest mitochondrial research and news, along with analyzing how it could impact mitochondrial disease research.

mitoworld.org/mitomedia/be...