Graeme Grimes

New insights into high grade serous ovarian cancer tumour evolution | Institute of Genetics and Cancer | Institute of Genetics and Cancer A study led by researchers at the Institute of Genetics and Cancer has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better trea...

A study led by @ailithewing.bsky.social has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better treatments: edin.ac/40vjn9a
@natcomms.nature.com @cmvm-edinburghuni.bsky.social

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer - Nature Communications Tumour evolution and heterogeneity in high grade serous ovarian cancer (HGSOC) remains poorly characterised. Here, the authors investigate the genomic landscape of HGSOC and reveal two distinct evolut...

New publication from the lab!
www.nature.com/articles/s41...

Amazing postdoctoral position for enthusiastic computational genomicist! @uoe-igc.bsky.social @edinburgh-uni.bsky.social

Will these talks me made available online after the event?

Pet dogs could combat genetic eczema risk in children Having a dog at home could help to prevent eczema in children who are genetically prone to the condition, a study suggests.

A pet dog could potentially combat genetic eczema risk in children says a new study led by Prof Sara Brown together with @bristoluni.bsky.social, @www.helmholtz-munich.de & @lshtm.bsky.social
Read more here 👉 edin.ac/3HqG1sG

We are hiring!
Want to join my new group at the amazing @uoe-igc.bsky.social and perform ground-breaking studies in reproductive genomics and genomic medicine as a computational genomicist?

Please DM me to discuss this, I will be attending #ESHG2025

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Happy #DNADay. Our work defining the molecular mechanisms of genetic disease and cancer, and the flow of information from DNA through to the production and regulation of RNAs and proteins, is critical to deliver pathways targetable by future therapies. institute-genetics-cancer.ed.ac.uk/about

CTCF-anchored chromatin loop dynamics during human meiosis - BMC Biology Background During meiosis, the mammalian genome is organised within chromatin loops, which facilitate synapsis, crossing over and chromosome segregation, setting the stage for recombination events and...

New publication from the lab! We used a machine learning approach to predict chromatin loop dynamics during human spermatogenesis - and find these structures do not direct gene expression but may drive the positioning of recombination events
bmcbiol.biomedcentral.com/articles/10....

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

Would you have accepted "RNA Sequencing" as the answer though?

Head shots of Professor Charlie Gourley (left), Professor Simon Herrington (centre) and Dr Robb Hollis (right)

March is #OvarianCancerAwarenessMonth. IGC researchers are leading significant advancements in our understanding of the disease. Dr Robb Hollis has written about work being undertaken at the Nicola Murray Centre for Ovarian Cancer Research into uncommon types of ovarian cancer: edin.ac/4jBEcId

Professor Charlie Gourley (left), Professor Simon Herrington (centre) and Dr Robb Hollis (right)

Today is #WorldCancerDay. At IGC, researchers are leading significant advancements in our understanding of the disease.
Dr Robb Hollis writes about research at the Nicola Murray Centre for Ovarian Cancer Research into uncommon types of ovarian cancer: edin.ac/4jBEcId

MRC four-year International PhD programme: Human Genetics, Genomics and Disease Applications now open.

Interested in an #interdisciplinary PhD on the #epigenetics of human disease (or know someone who is)? Come work with us through the 2025 MRC HGU PhD program. Excellent and friendly collegiate environment and a great city:
institute-genetics-cancer.ed.ac.uk/igc-graduate...

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FASTQ Base Quality Calculator - 42basepairs Bioinformatics calculator to convert FASTQ base qualities / Phred scores into an ASCII representation.

I also have calculators for exploring:

➡️ FASTQ base quality: 42basepairs.com/tools/fastq-...

➡️ SAM flags: 42basepairs.com/tools/sam-flag

If you know someone who would be a great #NextflowAmbassador, or maybe already is but without the title, please forward this reminder to them 😉

There is also excellent materials here carpentries-incubator.github.io/workflows-ne...