Vanja Tepavcevic

@biorxivpreprint.bsky.social Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus
www.biorxiv.org/content/10.1...

Job offer! Join our lab in the beautiful Basque Country! 🌊🌍🧠📚👇🏻

If you think your field needs a collection of curated reviews and protocols, let me know! Let's create it and help the community.

Mark your calendars!
The 28th Meeting of the French Glial Cell Club will take place Nov 17–20, 2026, in Sète.
🔹 Plenary lectures by Fiona Doetsch & Leda Dimou
🔹 5 symposia on glial diversity, astrocytes, human glia, EVs & modeling
👉 Full program available on our website: frenchglialcellclub.fr

White matter in focus symposium: Exploring the role of myelin and oligodendrocytes in neurodegeneration Current research is increasingly highlighting the role of oligodendrocytes in neurodegeneration and specifically in dementia. Explore this theme across disease areas in the upcoming symposium White…

WHITE MATTER IN FOCUS SYMPOSIUM: EXPLORING THE ROLE OF MYELIN AND OLIGODENDROCYTES IN NEURODEGENERATION

neuroscience.cam.ac.uk/event-posts/...

The microscopy core at Miami University is searching for a new director. Please consider sharing this job posting!

miamioh.wd5.myworkdayjobs.com/en-US/miamio...

Men’s brains shrink faster than women’s: what that means for Alzheimer’s Women’s brains age more slowly, but that doesn’t seem to protect them from a common form of dementia.

Men’s brains shrink faster than women’s: what that means for Alzheimer’s nature.com/articles/d41...

#Alzheimers #dementia #health #wellness #science

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social

“Using Human Brain Tissue in Research”

NC3Rs supported @nc3rs.bsky.social

Date & time: Friday, 7 November 2025 13:00–16:00

Prof Maria Thom
Mr Martin Gillies
Mr Ciaran S. Hill

Location: UCL Institute of Advanced Studies
Registration (event is free): www.eventbrite.co.uk/e/networking...

Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex - Cell Death & Differentiation Cell Death & Differentiation - Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex

Another evidence for lactate influx, not efflux, in neurons. However, it suggests that in neonates, where levels of circulating lactate are high, lactate used by neurons is blood-derived, and that neonatal astrocytes might also use lactate.
www.nature.com/articles/s41...

Prenatal Acetaminophen Exposure Does Not Disrupt Human Fetal Brain Development in Cortical Organoid Models https://www.biorxiv.org/content/10.1101/2025.10.07.681041v1

The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in C. elegans Alkalinization of glial cells mediates longevity, stress resistance, and protection from polyQ aggregation in C. elegans.

Alkalinization of glial cells increases lifespan and healthspan in C. Elegans
www.science.org/doi/10.1126/...

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

www.science.org/doi/10.1126/...

Interested in #epigenetics #DNAmethylation #omics #Dementia #oligodendrocytes? Join us tomorrow👇

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism https://www.biorxiv.org/content/10.1101/2025.10.07.680990v1

GlialCAM Cytoplasmic Signaling in Oligodendrocytes and Astrocytes is Essential for White Matter Homeostasis in the Brain https://www.biorxiv.org/content/10.1101/2025.10.03.680331v1

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science Translational Medicine www.science.org/doi/10.1126/...

Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.

What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO

Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...

Rhythmic metabolites in the E19 SCN peak during the day. Majority of rhythmic lipids and polar metabolites in the E19 SCN peak during the day, while there are more diverse phase clusters in the developed P28 SCN postweaning. Polar metabolites and lipids identified as rhythmic in E19 SCN (E19 clusters 1, top, and 2, bottom) were divided into subgroups based on hierarchical K-means clustering. Line plots on the left show traces of the normalized level of each rhythmic compound in each corresponding cluster. Bar plots on the right represent the lipid classes and polar metabolites in each rhythmic cluster.

How are #circadian rhythms established during development? This study shows that maternal metabolic signals oscillate in the fetal #SCN before the endogenous #clock becomes functional, offering a plausible mechanism for maternal entrainment of the developing clock @plosbiology.org 🧪 plos.io/3VD45fZ

Matinée NeuroMAP – Visite de laboratoire | NeuroMarseille

NeuroMAP @neuromarseille.bsky.social @univ-amu.fr organise une visite de laboratoire sur le campus de la Timone le 14 Novembre ! Venez rencontrer nos chercheurs 👩🏻‍🔬🧑🏽‍🔬

neuro-marseille.org/events/journ...

Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in …

"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth"
www.sciencedirect.com/science/arti...

Progenitor Timing Shapes NG2-Glia Fate and Oligodendrocyte Differentiation https://www.biorxiv.org/content/10.1101/2025.09.24.678191v1

Left: Image of the Drosophila melanogaster third instar larval ventral nerve cord used to examine mitochondrial morphology. Green fluorescence labels neuronal mitochondrial clusters decorated by a transgenically expressed Mito-GFP protein. Magenta fluorescence labels the Drosophila Bruchpilot protein, a component of active zones. Image credit: Bhagaban Mallik. Right: Image of synaptic boutons at the Drosophila melanogaster third instar larval neuromuscular junction rendered into three dimensions to quantify volumes of synaptic mitochondria. Green fluorescence labels neuronal mitochondria localized to the presynaptic boutons. Mitochondria are decorated by a transgenically expressed Mito-GFP protein. Magenta fluorescence labels the Drosophila Discs Large protein, an organizer of the postsynaptic density in the muscle. Image credit: Bhagaban Mallik and Thomas Moninger.

How do different tissues respond to mitochondrial dysfunction? @candrewfrank.bsky.social &co show that Complex I depletion triggers ROS-driven compensatory signaling in #MotorNeurons, but degeneration in muscles, with implications for #MitochondrialDisease @plosbiology.org 🧪 plos.io/4nLUIGJ

Top: Representative single-plane images showing co-expression of RGEPO1/2 and GCaMP6f in layer 2/3 neurons of the primary somatosensory cortex. Bottom: Top panel: Representative individual (light green and light red) and averaged (green and red) fluorescence responses of GCaMP6f and RGEPO1 during KA-induced seizures and subsequent spreading waves. Middle and bottom panels: Vertical projections of fluorescence profiles from neurons expressing GCaMP6f and RGEPO1 during KA-induced seizures and subsequent spreading waves.

Despite recent advances in green genetically encoded #potassium indicators (GEPOs), red-shifted GEPOs have been slower to come. @piatkevich.bsky.social &co present 2 new red #fluorescent #indicators for visualizing neuronal K+ dynamics in culture & in mice @plosbiology.org 🧪 plos.io/42niaSz

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com/articles/s41...

AlphaFold model of the complex formed between HK2 and the SOX10 5′UTR (189–204 nts). The predicted RNA structure is shown in cyan, and HK2 protein is shown in green. HK2 residues and SOX10 mRNA nucleotides at the interaction interface are highlighted in red. Inset: schematic representation of the secondary structure of the SOX10 5′UTR (189–204 nts) predicted by Mfold, with the putative HK2-binding region (194–198 nts) marked in red.

Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org 🧪 plos.io/3ViI1qL

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain. MRC GW4 BioMed DTP PhD studentship for 2026/27 Entry, Department of Clinical and Biomedical Science at University of... PhD Project - Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain. MRC GW4 BioMed DTP PhD studentship for 2026/27 Entry, Department of Clinical and Biomedical Science at...

📢 2 PhD positions on the role of GLIA in brain function 📢

Neuronal Clues to Astrocytes in the Developing Brain https://
tinyurl.com/4m3uuf2a
Neuroimmune strategy to treat Alzheimer’s disease https://
tinyurl.com/c7stnur5

#opportunities #neuroscience #neuroskyence #graduates