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Alexandra Nicaise

@telencephale.bsky.social

Incoming assistant professor @UAMS Neural stem cells & the choroid plexus in neuroinflammation using patient-based 2D and 3D models Senior Research Associate, Dept of Clinical Neurosciences, University of Cambridge

425 Followers  |  273 Following  |  2 Posts  |  Joined: 13.11.2024  |  1.7749

Latest posts by telencephale.bsky.social on Bluesky

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Endothelial gateways for brain lipid uptake and metabolism: www.jci.org/articles/vie...

A. Dushani Ranasinghe & Timothy Hla  Comment on Wenxin Song et al: www.jci.org/articles/vie...

10.10.2025 16:15 — 👍 2    🔁 2    💬 0    📌 0
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Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

10.10.2025 08:45 — 👍 40    🔁 19    💬 4    📌 2

Excited to see our work published in @cp-neuron.bsky.social !

12.10.2025 09:45 — 👍 2    🔁 1    💬 0    📌 0
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Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease - Molecular Neurodegeneration Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation. The choroid ple...

molecularneurodegeneration.biomedcentral.com/articles/10....

02.06.2025 16:55 — 👍 3    🔁 0    💬 0    📌 0

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