Alexandra Nicaise

Multi-modal choroid plexus pathology in aging and Alzheimer’s disease Brain barriers, cerebrospinal fluid (CSF) dynamics, and peripheral factors are implicated as significant contributors to Alzheimer’s disease (AD). The choroid plexus (ChP) is a blood-brain interface t...

Beautiful preprint by Maria Lehtinen's group on the impact of aging and Alzheimer's disease on the choroid plexus.

www.biorxiv.org/content/10.6...

Local B cell maturation and mast cell regulation of choroid plexus function in early life. Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social

Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis Bigotte et al. show that motile cilia on ependymal cells—epithelial cells lining the brain ventricles—are disrupted in multiple sclerosis. Using patient ti

Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis

academic.oup.com/brain/advanc...

A Multi-omic Atlas of Human Choroid Plexus in Alzheimer’s Disease The choroid plexus (CP) regulates barrier integrity, cerebrospinal-fluid (CSF) dynamics, and immune surveillance, yet its role in Alzheimer’s disease (AD) remains poorly defined. We performed snRNA-se...

www.biorxiv.org/content/10.1...

Endothelial gateways for brain lipid uptake and metabolism: www.jci.org/articles/vie...

A. Dushani Ranasinghe & Timothy Hla  Comment on Wenxin Song et al: www.jci.org/articles/vie...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

Excited to see our work published in @cp-neuron.bsky.social !

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease - Molecular Neurodegeneration Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation. The choroid ple...

molecularneurodegeneration.biomedcentral.com/articles/10....