Manuel Friese

We’re excited to introduce the new Hamburg #HertieNetwork fellows for the 3rd funding period: @felixfischbach.bsky.social, Märit Jensen, @brissiek.bsky.social & @janasonner.bsky.social. Looking forward to inspiring projects, discussions & collaboration across sites! #UKEHamburg #HertieStiftung

19.01.2026 08:34 — 👍 4    🔁 5    💬 1    📌 0

A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...

Check out our latest research on how a neuron-immune axis modulates peripheral immune responses during multiple sclerosis. We discovered it by exploring pregnancy-associated immune modulation in multiple sclerosis. Special thanks to Jana Sonner and Audrey Kahn:

www.nature.com/articles/s41...

15.01.2026 13:41 — 👍 10    🔁 4    💬 0    📌 1

We are hiring dedicated and motivated new members to join our basic and clinical research team at INIMS (www.inims.de), Universitätsklinikum Hamburg-Eppendorf.

- Medical Scientist (Postdoc)
- Clinician Scientist (Neurology)

Apply here:

www.uke.jobs/index.php?ac...

www.uke.jobs/index.php?ac...

30.12.2025 17:34 — 👍 1    🔁 1    💬 0    📌 0

Blue graphic with text saying: "Webinar: Innate immunity regulation of brain health on Thursday, November 20, 2025 at 2pm GMT/9am EST/10pm CST. Join Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology, Sam Rose, Scientific Editor of Neuron, David Hunt, Professor of Medicine at University of Edinburgh, Andrea Ablasser, Professor at École Polytechnique Fédérale de Lausanne, and Manuel Friese, Professor of Neurology at University Medical Center Hamburg-Eppendorf". The Cell Press and The Lancet logos appear in the top left and right corners respectively. Copyright: Elsevier Ltd.

👉 Register now: hubs.li/Q03NdTNP0
📆 Nov 20, 2025 | 2pm GMT / 9am EST / 10pm CST

Join our expert panel as they explore innate immunity’s role in neurological diseases, and therapies to prevent inflammation-driven neurodegeneration.

#neurology #brainhealth #lancetwebinar

05.11.2025 07:50 — 👍 7    🔁 2    💬 0    📌 0

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...

17.06.2025 19:18 — 👍 34    🔁 15    💬 1    📌 0

Interferon-induced immunoproteasome drastically decreases proteasomal activity in neurons, leading to a switch in neuronal metabolism with increased oxidative injury and ferroptosis @cellcellpress.bsky.social @manuelfriese.bsky.social
www.cell.com/cell/fulltex...

17.06.2025 16:44 — 👍 5    🔁 2    💬 0    📌 0

Arzt/Ärztin (all genders) in Weiterbildung - Neurologie mit Schwerpunkt Neuroimmunologie

We’re looking for a physician (f/m/d) with a strong interest in neuroimmunology and research in our MS outpatient clinic and day hospital team!
Join us in advancing care and science in a dynamic, interdisciplinary environment🧠

uke.jobs/index.php?ac...

06.06.2025 14:00 — 👍 1    🔁 2    💬 0    📌 0

Recommendations for robust and reproducible research on ferroptosis Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

Important walkthrough for newcomers in the field
rdcu.be/eg58p

09.04.2025 20:21 — 👍 14    🔁 9    💬 1    📌 2

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

21.02.2025 20:38 — 👍 36    🔁 12    💬 1    📌 1

We are hiring (2 positions) one
Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf

uke.jobs/index.php?ac...

uke.jobs/index.php?ac...

28.01.2025 08:39 — 👍 0    🔁 3    💬 0    📌 0

Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between UKE Hamburg, KU Leuven, Fraunhofer ITMP, Evotec:
www.cell.com/iscience/ful...

04.12.2024 11:37 — 👍 4    🔁 0    💬 2    📌 0