Manuel Friese

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...

Interferon-induced immunoproteasome drastically decreases proteasomal activity in neurons, leading to a switch in neuronal metabolism with increased oxidative injury and ferroptosis @cellcellpress.bsky.social @manuelfriese.bsky.social
www.cell.com/cell/fulltex...

Arzt/Ärztin (all genders) in Weiterbildung - Neurologie mit Schwerpunkt Neuroimmunologie

We’re looking for a physician (f/m/d) with a strong interest in neuroimmunology and research in our MS outpatient clinic and day hospital team!
Join us in advancing care and science in a dynamic, interdisciplinary environment🧠

uke.jobs/index.php?ac...

Recommendations for robust and reproducible research on ferroptosis Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

Important walkthrough for newcomers in the field
rdcu.be/eg58p

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

We are hiring (2 positions) one
Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf

uke.jobs/index.php?ac...

uke.jobs/index.php?ac...

Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between UKE Hamburg, KU Leuven, Fraunhofer ITMP, Evotec:
www.cell.com/iscience/ful...