Manuel Friese's Avatar

Manuel Friese

@manuelfriese.bsky.social

Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE

163 Followers  |  229 Following  |  3 Posts  |  Joined: 15.11.2024  |  1.4847

Latest posts by manuelfriese.bsky.social on Bluesky

Preview
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...

17.06.2025 19:18 — 👍 33    🔁 15    💬 1    📌 0
Post image

Interferon-induced immunoproteasome drastically decreases proteasomal activity in neurons, leading to a switch in neuronal metabolism with increased oxidative injury and ferroptosis @cellcellpress.bsky.social @manuelfriese.bsky.social
www.cell.com/cell/fulltex...

17.06.2025 16:44 — 👍 5    🔁 2    💬 0    📌 0
Preview
Arzt/Ärztin (all genders) in Weiterbildung - Neurologie mit Schwerpunkt Neuroimmunologie

We’re looking for a physician (f/m/d) with a strong interest in neuroimmunology and research in our MS outpatient clinic and day hospital team!
Join us in advancing care and science in a dynamic, interdisciplinary environment🧠

uke.jobs/index.php?ac...

06.06.2025 14:00 — 👍 1    🔁 2    💬 0    📌 0
Preview
Recommendations for robust and reproducible research on ferroptosis Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

Important walkthrough for newcomers in the field
rdcu.be/eg58p

09.04.2025 20:21 — 👍 14    🔁 9    💬 1    📌 2
Preview
Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

21.02.2025 20:38 — 👍 36    🔁 12    💬 1    📌 1

We are hiring (2 positions) one
Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf

uke.jobs/index.php?ac...

uke.jobs/index.php?ac...

28.01.2025 08:39 — 👍 0    🔁 3    💬 0    📌 0

Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between UKE Hamburg, KU Leuven, Fraunhofer ITMP, Evotec:
www.cell.com/iscience/ful...

04.12.2024 11:37 — 👍 4    🔁 0    💬 2    📌 0

@manuelfriese is following 20 prominent accounts