Grochowska lab (SynPro)

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...

The result of a fantastic Iwasa-Drubin lab collaboration.

@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...

Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites Lysosomal dysfunction is a well-recognized feature of aging, yet its systematic molecular investigation remains limited. Here, we employ a suite of tools for rapid lysosomal isolation to construct a m...

Great study!
www.biorxiv.org/content/10.1...

Cool initiative!

www.catcat-celltissuebiology.cat/2020/11/04/m...

Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable

www.theguardian.com/science/2025...

And this on top! www.nature.com/articles/s41...

Terrible...

The emerging mechanisms and functions of microautophagy - Nature Reviews Molecular Cell Biology Microautophagy involves direct engulfment of cytoplasmic components, including proteins and organelles, by lysosomes and late endosomes for degradation. Although it is one of three main types of autophagy — along with macroautophagy and chaperone-mediated autophagy — its mechanisms and physiological roles have only recently begun to emerge.

www.nature.com/articles/s41...
Excellent review! There is mounting evidence that results based solely on rapamycin and LC3 are insufficient to conclude that the observed changes are related to macroautophagy.

Congratulations!

How your email finds me (at 9pm)

How do neuronal lysosomes maintain functional synapses? - BIOspektrum The complex architecture of neurons poses unique challenges in maintaining proteome balance. Lysosomes, cellular metabolic hubs and main degradative organelles, play a central role in this process, thus supporting synaptic activity. Recent findings suggest that a specialized subpopulation of lysosomes in dendrites fuse with plasma membrane and release aggregation-prone proteins to the extracellular space. At the same time, they lead to structural changes in synapses, an intriguing link between the control of protein concentration and structural synaptic plasticity.

doi.org/10.1007/s122...
Lysosomes are much more than 'garbage dump', they are metabolic hub with really cool functions! If you are interested in this topic but would not like to go to deep in the molecular pathways (which are cool as well!), I hope you may find this contribution useful!

The beauty of these images will never stop amazimg me. Hippocampal (CA1) neurons expressing an artificial cytoplasmic protein partially targeted to lysosomes (black dots).

Other thing is that I have reviewed recently a paper with RNA seq data and the file with the seq list was missing. While some journals do request it in the publication phase, I believe that the editors should not send such a manuscript to review. It is incomplete.

Oh, I am sorry to hear that, this is really wrong. I do not have such an experience but actually I have never tried (I so far requested data from collaborators only). Would be cool to be able to initiate official data request via a link on the journal website.

What journals they looked at?

www.pro-test-deutschland.de

Exciting week with calibration of the FLIM module!

A lysosomal surveillance response to stress extends healthspan - Nature Cell Biology Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance...

Really cool story! Lysosomal surveillance response (LySR) is separate from mTOR-, AMPK-, and caloric restriction-related pathways as a potential key to longevity!

www.nature.com/articles/s41...

Why We Still Need Animal Research in a World of AI and Organoids The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

www.genengnews.com/topics/trans...

Team of Uni Hamburg crossed first the finish line. It was an amazing event!

How your email finds me

In Alzheimer’s disease, dimers do the damage - Nature Medicine Nature Medicine - In Alzheimer’s disease, dimers do the damage

www.nature.com/articles/s41...

"How, then, can one explain the continued resistance to this body of evidence? "

🎶 Straight from the Lab to the Mic: when a Pasteur scientist turns her thesis into a rap 🎶
#FeteDeLaMusique

Dendritic lysosomal exocytosis - can you imagine more fascinating topic? :D @ CNRS-CJM "Molecular basis for membrane remodelling and organisation"

Congratulations Mike and the team!

When you're back in your hotel room after a full day of talks and it's time to go to the concluding conference party

Does anyone have a tip for buying secondary Alexa Fluor conjugated antibodies in bulk? Which supplier do you use?

Congratulations!

Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...

I am also looking for PhD student to join the team! Please, share!