Subhojit Roy MD, PhD

Atmospheric river in San Diego means #sfn2025 must be in town.

Last ditch experiments before starting new journey!

7 basic science discoveries that changed the world Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.

Transformative medical discoveries from utterly basic science is not an exception. Its the rule.
nature.com/articles/d41...

"True; it might be a sin and shame, in such a world as ours, to spend a lifetime in this manner; but, for a few summer-weeks, it is good to live as if the world were Heaven"

Scientists are obsessed with intelligence. But you don't need an astronomical IQ to design a simple experiment that will slash through the darkness. In fact high IQ people often lack the simple-minded clarity needed for designing good experiments.

Yup. That outta do it.

but first we would need faculty vote and ass dean approval...

lol

...this BTW was the most productive thing i did today.

...UNLESS you are thinking of a Bumpety Bump?

...sorry i did not read the original message carefully, but according to my highly scientific analysis if gfp molecules truly didn't bind to actin (and if stress fiber was creating a bump) then there should be less cytoplasmic gfp where F-actin is...not more (yes, the "F" is used to annoy you).

But why is actin the only thing that's bumpy? There are probably a hundred other things in the ROI that exist but are not stained (like MTs)...first things to do is repeat with nothing in red channel and sequence the "GFP". Also...we need greyscale images.

Incredible by @odedrechavi.bsky.social...an AI-thingy that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why: www.qedscience.com

New lab pic with people who happened to be in the area...messy, so let's assume work is getting done.

we are busy moving the furniture...

What makes PhD students happy? Good supervision Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.

"Even short, regular check-ins can make a difference. Time spent helping students to solve problems, or simply asking how a project is going, will pay dividends. It also saves time later by catching small problems before they become big ones"

nature.com/articles/d41...

lol yes...i still remember most of them

UC wins 5 Nobel Prizes in 3 days — and sets a new world record These discoveries span decades and disciplines, but they all have one important thing in common: They’ve all relied on competitive funding from the federal government.

4 Nobels for UC in 2025, 75 since 1934, 1/4 winning women have ties to a UC.
www.universityofcalifornia.edu/news/uc-wins...

in cellulo then?

Ah but its not in vivo.

Case of the missing Lab Tupperware!

It won’t take you years to publish your work in JCS: most articles go from submission to acceptance in under 4 months. We also show a strong commitment at first decision, with over 95% of revisions being accepted. Find out more: journals.biologists.com/jcs/pages/re...
#forscientists
#notforprofit

SfN.SG Annual Symposium 2025 - Society for Neuroscience Singapore Chapter The Society for Neuroscience, Singapore Chapter (SfN.SG) is happy to announce that registration and abstract submission for the Annual Symposium are now open! The symposium will

I'm giving a talk at this SFN sponsored symposium in Singapore, students in the area consider submitting abstract - deadline coming up Oct 14: sfn.sg/sfn-sg-annua...

I went to #Chile for a conference 25 years ago - when Internet wasn't a thing - and this is all I needed to know. It went just fine.

“She took a character on the page and gave her such truth, precision and warmth that Hyacinth became part of the national conversation; instantly recognisable, endlessly quotable, and loved around the world"

Here's some animal data:
www.science.org/doi/10.1126/...
www.mdpi.com/2076-3425/11...

I tried to find a paper...no luck. Doing science with press reports, but is this even surprising anymore.

Huntington's disease breakthrough 'is like winning the lottery 10 times over' Families are elated by news of the first treatment for Huntington's disease - but when and how will the NHS fund it?

"So far, just the headline findings have been released. Scientists say the full study needs to be published and assessed by independent experts to properly assess what has been achieved" Umm...yes.

www.bbc.com/news/article...

Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial - Nature Medicine Interim trial results of MYR-101, a novel recombinant vector with selective tropism for oligodendrocytes, support its tolerability and indicate improved myelination and reduced cerebrospinal fluid N-a...

Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos! www.nature.com/articles/s41...

www.roylab.org/uploads/7/6/...