Marco Radi

🧪 The registration deadline for the First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy, has been extended! Here: lnkd.in/d6dnB8cc

Don’t miss the opportunity to share your work, connect with peers, and showcase your research in a high-impact venue.

🧪 We are delighted to present this #Wiley #Special #Collection inspired by two #international #conferences which debuted this year:
📍The First International Conference on Anti-Infectives 2025 in Saarbrücken, Germany
📍The First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy

🧪Complex diseases don’t work like broken clock that can be fixed by replacing a single part

As an alternative to the reductionist approach, we present a #multitarget #polypharmacological strategy to reduce drug #burden & prevent pulmonary #exacerbations in #CF
www.sciencedirect.com/science/arti...

🧪 In this work, we challenged ourselves to look beyond conventional #Antiviral #Drug #Discovery approaches, exploring an #evolution-#inspired strategy rooted in #prebiotic #chemistry. It’s been an exciting journey of creativity, curiosity, and collaboration.

www.nature.com/articles/s41...

www.efmc.info/mail_templat...

🧪This event, held in Catanzaro (Italy) on September 30 2025, will be focused on innovative #antiviral #DrugDiscovery #strategies.
To view the full program, register and submit an abstract, visit:
👉 lnkd.in/d6dnB8cc
📅 Registration deadline: July 25, 2025
📧 For further information: panviride@gmail.com

The #PANVIRIDE team from the Università degli studi di Parma. | Marco Radi The #PANVIRIDE team from the Università degli studi di Parma. A #multidisciplinary effort towards new Broad-Spectrum Antivirals (#BSAs). Learn more about our mission, research, and Partners on our o...

The #PANVIRIDE team from the Università degli Studi di Parma. 🧪
A #multidisciplinary effort towards new Broad-Spectrum Antivirals ( #BSAs).💊

Learn more about our mission, research, and Partners on our official website:
🔗 panviride.eu

www.linkedin.com/feed/update/...

This is one of the reasons why #peer #review for Scientific Journals should not be treated as an unpaid service, but rather recognized and compensated as a highly professional fee-based activity.

The surprising new idea behind what sparked life on Earth We may be starting to get a grasp on what kick-started life on Earth – and it could help us search for it on other planets

The interactions of droplets or water can spark flashes of electricity - microlightning - which would have provided enough energy to create the key organic molecules needed for life to emerge www.newscientist.com/article/2472...

Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype. Using the recently discovered…

Take a look at 'Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches'

From @marcoradi.bsky.social and first author Lisa Giannessi.

The Role of ATP Hydrolysis and Product Release in the Translocation Mechanism of SARS-CoV-2 NSP13 https://www.biorxiv.org/content/10.1101/2023.09.28.560057v1 In response to the emergence of COVID-19, caused by SARS-CoV-2, there has been a growing interest in

The Role of ATP Hydrolysis and Product Release in the Translocation Mechanism of SARS-CoV-2 NSP13 https://www.biorxiv.org/content/10.1101/2023.09.28.560057v1

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!

chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!

🤦

Structural Chemistry of Helicase Inhibition Helicases are essential motor enzymes that couple nucleoside-triphosphate hydrolysis with DNA or RNA strand unwinding. Helicases are integral to replication, transcription, splicing, and translation o...

An excellent perspective on different classes of #helicase #inhibitors 🧪
pubs.acs.org/doi/10.1021/...

Are the Trump team’s actions affecting your research? How to contact Nature Use this form to share information with Nature’s news team, or to make suggestions for future coverage.

Nature is asking for information about how your research is being affected by recent actions. Link is in article below. 🧪
www.nature.com/articles/d41...

I'm dead already then....😂

A big loss and very bad sign for NIH, folks

The sound of silence 🧪

Di sicuro sono più bravi di noi nell'inventare delle scuse populiste. Da noi ormai la caccia al barone universitario miliardario con casa alle Maldive a spese dei contribuenti è credibile come i vari decreti semplificazione...Ma i deputati bau bau possono ancora sorprenderci 😉

Perchè essere aggressivi quando basta un pò di italica burocrazia.....

Best thing I did so far....

A Lancet Editorial: “American chaos: standing up for health and medicine”

“...to care is an act not of weakness, but of strength.”

The Lancet response: bit.ly/4jRb5Av

🧪Have you ever wondered whether targeting #PI4KB and #Src / #Abl host kinases could be the next big thing in broad-spectrum #antiviral strategies? 🧐 Well, so did we! But instead of just wondering, we dug deep into the literature and wrote a whole review about it
www.sciencedirect.com/science/arti...

Fresh Asteroid, Getcher Fresh Asteroid Here

A detailed look at fresh samples taken from asteroid Bennu confirms that organic chemistry (and the molecules of life) are everywhere:

The Modern Medicinal Chemist’s Guide to Formulations With increasingly tight timelines between bench and clinic, considering formulation strategies early on can give your program a competitive edge. This succinct formulations guide provides specific cli...

Great overview of formulations fundamentals for medicinal chemists from Drug Hunter. drughunter.com/resource/the...

Attacking Estrogen-Receptor-Positive Breast Cancer

Via @dereklowe.bsky.social: I fear that we are about to enter a Lysenko-like era for American science. Can only hope that our privately funded organizations can keep doing good science, ride out this dark age and be able to pick up when the dust settles. www.science.org/content/blog...

“It sounds like someone trying to sell a new car model by pointing out that its windows roll up and down much more quickly”

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-objective molecular optimization The rapid and economical synthesis of novel bioactive compounds remains a significant hurdle in drug discovery efforts. This study demonstrates an integrated medicinal chemistry workflow that effectiv...

This is an impressive application of ML to drug discovery.

chemrxiv.org/engage/chemr...

🧪Broad-spectrum #antivirals💊 to fight emerging acute #infections and #coinfections are highly needed

www.who.int/emergencies/...