Dariusz Jan Smolinski

Researcher: "We let the data speak for itself."

Earlier that day:

02.01.2025 15:31 — 👍 8064    🔁 1028    💬 100    📌 70

#RNAsky #RNAbiology

02.01.2025 22:38 — 👍 8    🔁 4    💬 0    📌 0

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
#RNAbiology #RNAlocalization

www.cell.com/molecular-ce...

02.01.2025 23:49 — 👍 23    🔁 9    💬 0    📌 0

a man is standing on a sandy beach looking at the ocean ALT: a man is standing on a sandy beach looking at the ocean

Colleagues on X quote-tweeting Musk et al. to explain how they're wrong

28.12.2024 13:54 — 👍 11    🔁 1    💬 2    📌 0

A journal club on @lumasullo.bsky.social et al. RASTMIN paper (with explanations for non-microscopists audience) www.youtube.com/watch?v=ozKA...

18.12.2024 14:17 — 👍 18    🔁 4    💬 0    📌 0

Ångström-resolution fluorescence microscopy - Nature The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off...

ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY.

Can we do structural biology with an optical microscope? Yes!

Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out on 24.05.2023 in Nature! @natureportfolio.bsky.social

[re-post from Twitter]

27.11.2024 09:47 — 👍 254    🔁 71    💬 9    📌 19

Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body https://www.biorxiv.org/content/10.1101/2024.11.28.625872v1 Small subcellular organelles orchestrate key cellular functions. How biomolecules are spatially orga

Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body https://www.biorxiv.org/content/10.1101/2024.11.28.625872v1

29.11.2024 18:48 — 👍 3    🔁 3    💬 0    📌 1

We’ve just installed a new Abberior STED FACILITY LINE microscope at Nicolaus Copernicus University. Next week, we begin studying Cajal bodies, P-bodies, SG and other biomolecular condensates in post-transcriptional gene regulation. Thanks @ministerstwonauki.bsky.social for their financial support.

08.12.2024 21:57 — 👍 1    🔁 0    💬 0    📌 0