Tamer Ali

This highly innovative in-vivo cell-tracking tool uses nanobody-based PET imaging to track unmodified transplanted cells in immunocompetent mice and avoids bulky antibodies or genetic engineering.
buff.ly/W2layjv

This is why Israel refuses to allow the international press access to Gaza.
Because images like this make it impossible to deny that this is genocide.

Temporal and spatial omics technologies for 4D profiling Nature Methods - This Perspective explores advances and future directions in spatiotemporal omics methods for four-dimensional profiling.

Nature Method: Temporal and spatial omics technologies for 4D profiling
www.nature.com/articles/s4...

Further evidence that the #gastruloid system models the natural embryo from this spatiotemporal map of mouse #gastrulation
www.cell.com/cell-reports...
important as it provides a context for the, some times surprising, findings that the model is providing.

Starvation in Gaza is destroying communities – and will leave generational scars Health and societal ramifications of extreme hunger will reverberate long after the war is over

www.theguardian.com/world/2025/j...

Not even a single rape case. You people never stop fake narrative. Just want to justify your terror.

Everyone who fights to free his land is a hero and his act is courageous.

Go check you twitter tweets after the courageous attack on October 7th.
You said “we have the write to defend ourselves”. Since then I unfollowed your account. This not a lie. Please. Go check it out.

You were supporting this horror initially.

In vivo prime editing rescues alternating hemiplegia of childhood in mice Prime editing and base editing in mouse models and human cells effectively correct mutations in a gene that causes a childhood neurodevelopmental disorder called alternating hemiplegia of childhood. In vivo prime editing in the brain results in significant improvements in neurological symptoms and lifespan, highlighting a potential one-time gene therapy approach for the disorder.

Now online! In vivo prime editing rescues alternating hemiplegia of childhood in mice

In vivo prime editing rescues alternating hemiplegia of childhood in mice Prime editing and base editing in mouse models and human cells effectively correct mutations in a gene that causes a childhood neurodevelopmental disorder called alternating hemiplegia of childhood. I...

One-shot prime genome editing ("CRISPR 3.0") of the brain in vivo corrected AHC, a rare genetic disorder, in the mouse model. Another big step forward in the genome editing field.
www.cell.com/cell/fulltex...

GitHub - vierstralab/hotspot3: A chromatin accessibility peak caller with an adaptive background model A chromatin accessibility peak caller with an adaptive background model - vierstralab/hotspot3

We have created a new DNase I- & ATAC-seq peak caller that uses an adaptive background model that controls for copy number variation & aneuploidy. It performs a per-nucleotide test (+FDR correction) and is very fast. Please try it out and give us feedback!

github.com/vierstralab/...

New online! Non-retroviral RNA viruses in eukaryotic genomes

Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...

🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh

STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging @cellcellpress.bsky.social @lgmartelotto.bsky.social @hoheyn.bsky.social
www.cell.com/cell/fulltex...

Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain In Drosophila, tethering elements are DNA regulatory regions that facilitate long-range interactions between enhancers and promoters as well as between the promoters of distant paralogous genes. Hu et al. demonstrate that the Vostok protein binds to these elements in the larval brain and is essential for the correct expression of associated genes.

Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain

Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...

Molecular basis of positional memory in limb regeneration - Nature A molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into posterior cells.

Nature research paper: Molecular basis of positional memory in limb regeneration

https://go.nature.com/44OtQj3

Here we study the origin of the cardiac cell lineages in the mouse embryo. Separate but coordinated lineages independently specified at gastrulation generate the myocardium and endocardium. Credits: Miquel Sendra & coll: Jorge Dominguez, K. McDole and L. Guinard
authors.elsevier.com/sd/article/S...

1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

Powerful CRISPR system inserts whole gene into human DNA ‘Directed’ evolution in the laboratory creates an editing tool that outperforms classic CRISPR systems.

🧬 CRISPR just levelled up

A new tool, evoCAST, can insert entire genes into human DNA, with no cutting required.

Hopefully this is one step closer to safe, scalable gene therapies.

🔗 doi.org/10.1038/d415...

#SciComm #CRISPR #GeneTherapy 🧪

Engineered nucleocytosolic vehicles for loading of programmable editors Engineered nucleocytosolic vehicles for loading of programmable editors (ENVLPE) with enhanced CRISPR ribonucleoprotein (RNP) loading and stabilization enable the efficient delivery of gene-editing ef...

engineered nucleocytosolic vehicles for loading of programmable gene editors www.cell.com/cell/fulltex...

Great work from Steven Henikoff’s lab

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...

I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com!
🔗 tinyurl.com/3jkzzy7d

Great work Pedro. I have a question if I may ask: did you see the same phenotype upon inverting C1-C4 motif?

An innovative approach using CRISPR-ribonucleoprotein packaged in virus-like particles to generate genetically engineered mouse models - Nature Communications Gene-edited mouse models are crucial for disease research but remain challenging to create. Here, authors introduce the CRISPR-VIM, using virus-like particles to efficiently deliver CRISPR tools into ...

Following up on the LVNP innovation, here’s an impressive study demonstrating the use of LVNP to generate transgenic mice in a straightforward manner. The study successfully employed both knockout and knockin approaches, achieving remarkable success rates.

www.nature.com/articles/s41...

Two tools for plotting genomics data:

figeno: Tool for making genomics figures in #python. github.com/CompEpigen/...

Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11

Again. Cool technology from Henikoff lab.