Deirdre Logsdon, PhD

Induction of experimental cell division to generate cells with reduced chromosome ploidy - Nature Communications Researchers induced ploidy reduction in human oocytes generated by somatic cell nuclear transfer, enabling fertilization and embryo development with integrated somatic and sperm chromosomes, highlighting a proof-of-concept for in vitro gametogenesis.

Functional human eggs have been generated from skin cells in a proof-of-concept study in @natcomms.nature.com. The technique could offer a new path to treating infertility, though more research is needed before clinical use.

#devbio

www.nature.com/articles/s41...

01.10.2025 19:17 — 👍 3    🔁 1    💬 0    📌 0

‘Congress has your back’: US senators tell scientists they want to protect NIH budget Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.

www.nature.com/articles/d41...

04.08.2025 14:31 — 👍 0    🔁 0    💬 0    📌 0

SSR annual meeting was such a blast. Didn’t realize how much I needed my repro friends!
@ssrwinrs.bsky.social
#reprorocks #womeninSTEM

04.08.2025 14:29 — 👍 8    🔁 0    💬 0    📌 0

Going to the SSR annual meeting and need childcare support? Apply for a childcare grant through WinRS! #momsinstem #happymothersday

12.05.2025 17:34 — 👍 3    🔁 1    💬 0    📌 0

Attention SSR Annual Meeting attendees:
Don't miss registration for the Lunch and Learn session with Dr. Kelly Diggs to sharpen up your mentoring skills!
#reprorocks #womeninstem

29.05.2025 20:37 — 👍 5    🔁 3    💬 0    📌 0

Happy Pi Day y’all!

14.03.2025 22:02 — 👍 2    🔁 0    💬 0    📌 0

#womenshistorymonth #womeninstem

04.03.2025 22:16 — 👍 10    🔁 2    💬 0    📌 0

Listen to 2024 Roger V Short Medal Awardee, Dr. Francesca Duncan, discuss ovarian aging and give trainees a bit of her wisdom on the latest SSR podcast! 👏👏👏
#womeninSTEM #reprorocks
Listen to the full episode here 👇https://www.buzzsprout.com/1786803/episodes/16143433

16.01.2025 16:41 — 👍 7    🔁 5    💬 0    📌 0

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium - Nature Cell Biology Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state and expression of genes ...

I’m SO proud of my postdoc lab for publishing their first Brumbaugh Lab paper in @NatureCellBio today! Check out how altered H3K36 methylation impacts intestinal cell plasticity 👇
www.nature.com/articles/s41...

Congratulations @Brumbaugh_JB 🥳

09.01.2025 00:11 — 👍 3    🔁 0    💬 0    📌 0

Working model of the impact of Slc25a1 deficiency on placental and embryonic cardiac development. In the normal placenta (left), SLC25A1 facilitates the transport of citrate from mitochondria to the cytoplasm. Citrate is converted into acetyl-CoA, which is essential for maintaining H3K27ac and promoting the differentiation of trophoblast cells. Trophoblast cells secrete PSG proteins, supporting normal placental and embryonic heart development. In the absence of Slc25a1 (right), citrate cannot be transported from mitochondria to the cytoplasm, resulting in a reduction in acetyl-CoA levels. This leads to reduced deposition of H3K27ac at the promoter and enhancer regions of key factors involved in trophoblast differentiation and Psg genes, thereby affecting the expression levels of these genes and causing abnormal placental development, which in turn leads to conotruncal defects and thinner ventricular walls in mouse embryonic hearts.

Wenli Fan et al. leverage conditional mouse knockouts to explore the link between placental problems and congenital heart defects, showing that SLC25A1 regulates trophoblast differentiation and placental development to safeguard embryonic heart formation. 🐭🫀 https://bit.ly/4g372OU #DevBio

27.11.2024 14:38 — 👍 24    🔁 4    💬 1    📌 1