Sébastien Guizard

A political cartoon shows a man resembling Donald Trump being spat on by the image of Alfred Nobel from a Nobel Prize medal. The man squints and grimaces as the liquid hits his face. The medal is bright gold, and Trump is dressed in a blue suit with a red tie. The artist’s signature, “Nico Cornill,” and social media handles appear at the bottom right.

The Nobel verdict! 💯🤣

"Une solution majeure à une arnaque"... qui elle-même est une arnaque. C'est littéralement une promesse impossible à tenir. Mathématiquement, baisser de 300% ça veut dire rendre de l'argent à ceux qui achètent. Est-ce qu'il reste quelqu'un qui réfléchisse à ce que cette administration raconte ?

GitHub - facebook/openzl: A novel data compression framework A novel data compression framework. Contribute to facebook/openzl development by creating an account on GitHub.

Meta open-sources OpenZL

A new data compression library and training tools to generator specialized compressors for structured data, achieving performance levels inaccessible to classic generic algorithms.

github.com/facebook/ope...

Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.

🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

Beware of the pain au chocolat reply...

Comic. PERSON 1 to person with white hat: I finished all the gen-ed back in 2010, and I’m up to the 400-level courses in most departments. But now one of my advisors is saying I “can’t have more than 20 majors” and “need to graduate next year.” It’s outrageous! [caption] My university is making it really hard to finish a 100% all achievements speedrun.

100% All Achievements

xkcd.com/3148/

🦒Long read giraffe is out!🦒
Mapping long reads to pangenome graphs is ~10x faster than with GraphAligner, with veeery slightly better mapping accuracy, short variant calling, and SV genotyping than GraphAligner or Minimap2

YouTube video by Info ou Mytho ? La bulle d'information / Super pouvoirs anti-mythos - Info ou Mytho

Je vous proposerai chaque mois un entraînement aux super-pouvoirs sur "Info ou mytho ?", la chaîne d'esprit critique pour les ados, qui me fait le plaisir d'accueillir cette chronique.
Ce mois-ci, le super pouvoir consiste à sortir de sa bulle.
Faites tourner ! 😉
www.youtube.com/watch?v=z98L...

@nikomccarty.bsky.social posts on scFLUENT-seq

Do you know ~60% of human SVs fall in ~1% of GRCh38? See our new preprint: arxiv.org/abs/2509.23057 and the companion blog post on how we started this project and longdust: lh3.github.io/2025/09/29/o.... Work with Alvin Qin

Thanks to @nrennie.bsky.social, llamo Illak Zapata, and Abdoul Madjid for designing the tables and sharing the code I adapted in the gallery.

Thanks to Posit for organizing the Rstudio table contest and for encouraging contestants to publish their code and data openly!

PAQman: reference-free ensemble evaluation of long-read eukaryotic genome assemblies. #GenomeAssembly #LongReads #AssemblyQC #AssemblyEvaluation #Bioinformatics #Genomics @biorxivpreprint.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...

🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...

Detecting Foldback Artifacts in Long-reads. #LongReads #ReadsArtifacts #QC #Bioinformatics #Genomics @biorxivpreprint.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...

usethis/R/rcpp.R at f8a7bb7eef0fbb11cc81aa182c0f13ffb3e2695f · r-lib/usethis Set up commonly used 📦 components. Contribute to r-lib/usethis development by creating an account on GitHub.

Maybe this is it: `usethis::use_rcpp_armadillo`

github.com/r-lib/usethi...

Termal: a fast and interactive terminal-based viewer for multiple sequence alignments. #MultipleSequenceAlignments #TerminalViewer #interactiveViewer #Bioinformatics @bioinfoadv.bsky.social
academic.oup.com/bioinformati...

Un témoignage accablant au Sénat US contre RFK Jr, le secrétaire à la santé américain, qui établit comment il veut restreindre l'accès aux vaccins pour des raisons purement idéologiques sans aucune donnée scientifique. Il s'agit de Susan Monarez, ex directrice du CDC (agence de santé publique). [1]

Workers Are Getting Fired Over Posts Mocking Charlie Kirk’s Death Campaigns to alert employers to contentious posts are posing new challenges for bosses; ‘This is very different’ from past political controversies at work.

Aux États-Unis, le camp de la « liberté d’expression » a lancé un harcèlement massif ciblant des personnes ayant exprimé des opinions négatives, parfois extrêmes, sur Charlie Kirk

La prochaine fois que l’extrême-droite française parle de « liberté d’expression », souvenez-vous de cette hypocrisie

Exploring {ggplot2}’s Geoms and Stats – Stat’s What It’s All About

New blog post!

Ever wonder what geom_histogram is actually doing? How about geom_boxplot?

In celebration of the release of #ggplot2 4.0.0 (ggplot8?), I explore the relationships between the “geoms” and “stats” offered by the core {ggplot2} functions.

#rstats

Pendant ce temps-là, Trump résout des conflits.

Now preprinted at arxiv.org/abs/2509.07357

YouTube video by useR! Conference Plot Twist: Adding Interactivity to the Elegance of ggplot2 with ggiraph

Great video with @tanyashapiro.bsky.social and @cedricscherer.com walking us though using {ggiraph}. Plus, there's a plot with some #DrWho data :-)
#data #Rstats #code
www.youtube.com/watch?v=GnDj...

Dans l'écosystème BlueSky, les suiveurs de Peltier-Lamy travaillent d'arrache pied à détruire ma réputation, notamment en intimidant celles et ceux qui collaborent avec moi.

Mais...

Le « Pape de l’IA » — Luc JULIA est-il un imposteur médiatique ? YouTube video by La Tronche en Biais

Emission spéciale mercredi 9 septembre, 20h.

Luc JULIA, présenté comme « co-créateur de Siri », est considéré comme un « expert mondialement reconnu », parfois même comme « le pape de l’intelligence artificielle ».

youtube.com/live/zFwLAOg...

Democrats And Republicans Rally With Epstein Victims In Push To Release Files “I am no longer weak, I am no longer powerless and I am no longer alone,” said one woman who said she was abused by Epstein.

Epstein files : puisque selon l'administration Trump il n'existe pas de liste, les victimes en conférence de presse devant le capitole annoncent qu'elles vont faire la leur. Une victime républicaine rappelle au passage à Trump qu'il ne s'agit pas d'un hoax démocrate.
www.huffpost.com/entry/epstei...

Hi, I’m Julie Cruse. I created AcademicAbuse.com – a dashboard of data, resources & tools to help survivors of academic abuse survive and safely speak out. (1/9 🧵)

🪜 🎓 📜 🍎 ♀️ 👩🏾🔬 👩🏼🔬 👩🏾🎓 #PhDSky #Blackademia #AcademicChatter #AcademicSky #MeToo #HigherEd #PhDChat #TimesUpHigherEd

Research posts on Bluesky are more original — and get better engagement Bluesky posts about science garner more likes and reposts than similar ones on X.

Posts about research on Bluesky receive substantially more attention than similar posts on X, formerly called Twitter

go.nature.com/45Ftiw4

anndataR enables seamless R-Python interoperability for single-cell RNA-seq by reading, writing, and converting H5AD files, supporting Seurat and SingleCellExperiment formats www.biorxiv.org/content/10.1... 🧬🖥️🧪 #Rstats github.com/scverse/annd...

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