Serena Orr, MD, MSc

Teva Canada Announces Approval of Expanded Indication of [Pr]AJOVY® (fremanezumab solution for subcutaneous injection), the First Anti-CGRP Preventive Treatment for Pediatric Episodic Migraine Health Canada approves PrAJOVY® (fremanezumab solution for subcutaneous injection) for the prevention of episodic migraine (fewer than 15 migraine days per...

We have our first ever on-label #migraine #preventive intervention for #children and #adolescents in #Canada as of this AM. Very exciting for youth with migraine and providers: www.newswire.ca/news-release... @kidsinpain.bsky.social

New study on #preventive #gepant use in #children and #adolescents with #headache disorders and #migraine
headachejournal.onlinelibrary.wiley.com/doi/epdf/10....

Just published our #update of the @ahsheadache.bsky.social #guidelines on the #management of #migraine in the #EmergencyDepartment @headachejournal.bsky.social
headachejournal.onlinelibrary.wiley.com/doi/epdf/10....

US Burden of Disorders Affecting the Nervous System This cross-sectional study analyzes data from the Global Burden of Disease 2021 study to quantify aggregated health loss from diseases affecting the nervous system in the United States.

#Migraine remains the #top cause of #neurological #disability in #children and #adolescents in the 2025 GBD neurological diseases publication @jama.com: jamanetwork.com/journals/jam...

<em>Headache: The Journal of Head and Face Pain</em> | AHS Journal | Wiley Online Library Objective To explore the relationship between migraine attack onset in children and adolescents and Chinooks, which are dry and warm westerly winds that generally occur in the winter and bring about...

Hot off the press: Our work on #Chinook #winds and #migraine attack onset in #children and #adolescents with surprising null findings @ahsheadache.bsky.social @headachejournal.bsky.social : headachejournal.onlinelibrary.wiley.com/doi/10.1111/...

Beautiful #autumn morning over #Minneapolis; headed to #AAN HQ.

Serena L. Orr | Top 40 Under 40 2025 - Avenue Calgary Serena Orr is changing the way health-care providers view and treat headache disorders.

What a week - Honored to be a #Top40 and our paper on #migraine and #trauma informed care was published.

Top 40: www.avenuecalgary.com/top-40-under...

Migraine and trauma-informed care: link.springer.com/epdf/10.1007...

Neurology® Journals

Interesting data: Dual therapy with #anti-CGRP medications and #OnabotulinumtoxinA resulted in reduced #EmergencyDepartment visits compared to monotherapy with either of these in #adults with #migraine www.neurology.org/doi/pdf/10.1...

Glad to see the American Academy of Neurology respond swiftly to the HHS’ claim linking #autism to prenatal acetaminophen exposure: www.aan.com/siteassets/h...

Fabulous time in São Paulo sharing #migraine #science, #clinical pearls, and working on international #collaborations with my wonderful colleagues #InternationalHeadacheCongress

“Pain metamorphosis” - striking art at the #InternationalHeadacheCongress in #SãoPaulo

Headed down to #SãoPaulo for the #InternationalHeadacheCongress meeting. Excited to share our recent work on #chinooks and #migraine attack onset in #children and #adolescents and to lecture on #non-pharmacologic treatments.

<em>Headache: The Journal of Head and Face Pain</em> | AHS Journal | Wiley Online Library Pain catastrophizing is a term that describes a person's tendency to magnify (i.e., to feel threatened) by pain, to ruminate (i.e., to think a lot) about pain, and to feel helpless about pain. We exa...

Check out our latest work showing that #pain #magnification (perceiving pain as #threat) is strongly associated with more #migraine related #disability at follow-up in youth with migraine @ahsheadache.bsky.social @headachejournal.bsky.social: headachejournal.onlinelibrary.wiley.com/doi/10.1111/...

FDA has approved #fremanezumab for #migraine #prevention in #children and #adolescents with #episodic #migraine ir.tevapharm.com/news-and-eve...

Open Access:
A discrete-choice experiment survey in adults w episodic #migraine found, on average, respondents prefer an oral pill to injections or infusions, highlighting the importance of patient preference in choosing preventive treatments
headachejournal.onlinelibrary.wiley.com/share/BYXMW2...

<em>Headache: The Journal of Head and Face Pain</em> | AHS Journal | Wiley Online Library There are limited treatment options to prevent migraine in young people (aged 6–17 years). Eptinezumab is proven to prevent migraine in adults, and in this open-label trial, we gave eptinezumab to yo...

The #phase1 #pharmacokinetic #trial on the use of #eptinezumab in #children and #adolescents with #migraine is now published. Recommends weight-based dosing. @headachejournal.bsky.social headachejournal.onlinelibrary.wiley.com/doi/pdf/10.1...

In Calgary!

a man applauds in front of a sign that says schitts sook proud ALT: a man applauds in front of a sign that says schitts sook proud

That feeling when your #graduate student has a masterful #defense @ucalgarymed.bsky.social

RECAP | Woman’s testimony ends after 9 gruelling days of questions at world juniors sex assault trial | CBC

A woman took 5 hockey players to trial for alleged sexual assaults. She was subjected to 9 straight days of interrogation by 5 legal teams, one for each defendant. Our justice system is telling women they can't report multiple assaults or they will be victimized again.
www.cbc.ca/news/canada/...

Nothing to do with headache medicine but this is a great read 😊

Fremanezumab for the Treatment of Patients With Migraine and Comorbid Major Depressive Disorder This randomized clinical trial investigates if treatment with fremanezumab compared with placebo leads to improvements in migraine and depressive symptoms in patients with migraine and comorbid major ...

Fascinating results from UNITE trial showing that #fremanezumab reduces both #migraine days and #depressive symptoms in adults with #migraine and #depression - seminal trial first to look at treating both @jama.com: jamanetwork.com/journals/jam...

The little hat, the eye piece, the weird block suit. So quirky, so neuro

CONSORT 2025 statement: updated guideline for reporting randomised trials Well designed and properly executed randomised trials are considered the most reliable evidence on the benefits of healthcare interventions. However, …

The #CONSORT guidelines for #reporting the results of #RandomizedControlledTrials have been updated and published. See the new guidelines here: www.sciencedirect.com/science/arti...

YouTube video by Alberta Health Services Headache in kids and teens: Causes, treatment approach, and mental health (April 10, 2025)

I was invited by
@abhealthservices.bsky.social
to do a presentation for #youth and #families about #headaches and #migraine in #children and #adolescents and it is now posted on Youtube in case anyone is interested: www.youtube.com/watch?v=BHq-...

Prediction of new-onset migraine using clinical-genotypic data from the HUNT Study: a machine learning analysis - The Journal of Headache and Pain Background Migraine is associated with a range of symptoms and comorbid disorders and has a strong genetic basis, but the currently identified risk loci only explain a small portion of the heritabilit...

Fascinating work using #MachineLearning to try and predict #incident #migraine cases in the HUNT study from #genetic and #clinical data. #Genetic data alone barely better than chance, but #clinical + #genetic data generated reasonable predictive accuracy: link.springer.com/article/10.1...

There's no such thing as a self-made man or woman. No one succeeds without support.

"I did it on my own" is a sign of insecurity and entitlement. Acknowledging help is a mark of confidence and humility.

Giving credit to others doesn't undermine you. It elevates them.

Gender Wage Gap Among Academic Neurologists | Neurology ObjectivesDespite efforts to reduce the gender wage gap, a 2019 survey of American Academy of Neurology members showed that a significant gender wage gap was still evident. This study aims to assess t...

The #gender #WageGap for #neurologists is not improving @greenjournal.bsky.social: www.neurology.org/doi/10.1212/...

Back in my #hometown @Montreal for the International Brain Injury Association Congress, preparing my talk on #posttraumatic #headache in #children and #adolescents. Excited to connect with some #colleagues, #family, and #friends

Knowledge Broker to Improve Pain in Children and Families, Anaesthesia in Calgary, AB, ... Knowledge Broker to Improve Pain in Children and Families, Anaesthesia in Calgary, AB, ...

My standout colleagues Drs. Noel & Birnie are looking to hire a #KnowledgeBroker to work on projects related to #pediatric #pain. Please consider and/or share! careers.ucalgary.ca/jobs/1579389...

Mike spotted this before the rest of us. 🫡

Publications from 2025 are shared more on Bluesky than on X/Twitter.