SJo

Dopamine’s secret agent: serotonin Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent—instituting a high-...

Happy to share this Spotlight article, drawing attention to recent work by @borgkvistlab.bsky.social on the mechanisms of dopamine action in the SNr.

Read our summary and then read their paper! Many cool implications!
@cp-trendsneuro.bsky.social

www.cell.com/trends/neuro...

From an imessage conversation, newer first: Unknown: OK Epstein?: both are welcome to our secret society , they will join join joi ito ed boyden and caleb . (mit agro)

for fuck's sake
www.justice.gov/epstein/file...

Taylor Swift embodies female economic power in new book by KU professor • Kansas Reflector Misty Heggeness released “Swiftynomics,” a book explaining how female economic power radiates from the music star.

Taylor Swift embodies female economic power in new book by KU professor kansasreflector.com/2026/01/30/t...

Ick!!!!!!

nearly a thousand entries

every epstein file drop underscores how elite power operates through shared socio-economic networks, regardless of people's ideological differences, populist posturing, or public feuds

A stress-dependent postembryonic role for the core CPA factor CFIM-1 in germline integrity Abstract. Post-transcriptional processing of pre-mRNAs by alternative polyadenylation (APA) generates a diversity of transcript isoforms at the 3’ untransl

I am pleased to share our latest paper on the role of the alternative polyadenylation factor CFIM-1 (NUDT21) in C. elegans germline development. academic.oup.com/genetics/adv...

Why emotion research is stuck—and how to move it forward Studying how organisms infer indirect threats and understand changing contexts can establish a common framework that bridges species and levels of analysis.

My perspective in @thetransmitter.bsky.social on why emotion research feels stuck and how we might move forward—by focusing on how the brain uses internal brain models to shape emotional processing across species. www.thetransmitter.org/emotion/why-...

Save the date for the annual "Neural Circuits and Behaviour" satellite conference at the Canadian Association for Neuroscience annual meeting, cohosted by @franklandlab.bsky.social and myself on May 18, 2026. We have a great speaker lineup and will be selecting 4 trainees talks from our registrants!

The Heritage Minutes: Wilder Penfield
It is one of the most famous Heritage Minutes ever made, all thanks to "I smell burnt toast"
And the story of Wilder Penfield is one of a man who expanded our knowledge of the brain.

Nominate a colleague for the Peter Seeburg Integrative Neuroscience Prize! Your nominee should exemplify an innovative spirit and contribute significantly to understanding the brain.

The award will be presented at the FENS Forum and the recipient will receive a $100,000 prize.

vist.ly/4mh9i

It has not escaped our notice that this very amygdala-centric paper was just published in a journal called "Hippocampus"!

Huge thanks to @awheel-lab.bsky.social and @franklandlab.bsky.social and the rest of the crew for guidance.

Our 3D mapping reveals that the amygdala has a highly organized, hierarchical engram architecture.

Interestingly, we observed lots of similarities between the architecture of neurons engaged when mice recalled an aversive vs. a neutral memory, suggesting the amygdala engrams have similar architecture regardless of memory valence.

At the network level, we used graph theory and found that engram ensembles are structured networks with "hub" neurons. These hubs likely function as major communication centers for efficient memory recall.

At the micro-scale level, rather than being randomly distributed, we observed active neurons form tightly packed clusters. These local modules may be the building blocks that allow neurons to interact and stabilize the engram.

At the meso-scale, we identified specific spatial hotspots of high engram neuron density that are differentially engaged during fear learning and retrieval across different amygdala nuclei

Examining the Three‐Dimensional Spatial Architecture of Mouse Amygdala Engram Ensembles Memories are stored in a sparse population of neurons active at the time of an event, an engram ensemble, and reactivation of the engram ensemble drives memory recall. Although the amygdala is essent...

New Year, new paper from our lab. Emily Kramer used 3D light-sheet imaging and tissue clearing to examine the spatial architecture of mouse amygdala engram ensembles.

onlinelibrary.wiley.com/doi/10.1002/...

Body size predicts the selection of defensive behavioral strategies Survival depends on the ability to respond appropriately to threats, yet the selection of defensive behaviors varies among individuals with distinct b…

New paper from @ykneurores.bsky.social in our lab 📢
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...

Frontiers | Taylor Swift versus Mozart: music preferences of C57BL/6J mice IntroductionMusic has become an established complementary element of modern medicine, demonstrating beneficial effects towards various diseases such as demen...

Will find way to incorporate this into next talk! 🫶

Join us for Fall 2026. In our group, you can run studies from human behavior and neuroimaging, to large-scale NHP ephys, and join them up with a robust computational foundation. Bonus: you can help build the reading list.

How to Change a Memory: One Neuroscientist’s Quest to Alter the Past by Steve Ramirez

@okaysteve.bsky.social's How to Change a Memory is out now!

In this book, Ramirez draws on his own memories to reveal how memory can be turned on & off like a switch, edited, & even constructed from nothing.

Explore a free sample: press.princeton.edu/books/hardco...

#Neuroscience #Memory

Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase Amides of squaric acid are new drug candidates with activity against mycobacteria. Like the approved drug bedaquiline, these compounds achieve efficacy by inhibiting mycobacterial ATP synthase. Howeve...

Exciting collab with Paul Palme, Peter Imming, & Adrian Richter!
Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f
#MedChem #TB #NTM
pubs.acs.org/doi/full/10....

Brenda Milner showed the world that memory isn’t one thing — the hippocampus supports our life stories, while other circuits let us keep learning skills.
Her research on patient H.M. built the foundation of cognitive neuroscience.
#WomenInScience #MemoryResearch #NeuroHistory

Love this💕 Thanks @bsneuroendo.bsky.social for giving me the platform to share my story. Everyone should join this amazing society! @infneuroendo.bsky.social

📣 #MCCS25 starts TOMORROW! Check out our poster session tomorrow & our symposium on Friday to hear from the best and brightest in molecular and cellular cognition.

More information here: event.fourwaves.com/MCCS25/pages

.@andpru.bsky.social CRC in Sensorimotor Neuroscience and @schulichmeddent.bsky.social professor and his collaborators recently published in Nature on how our brains not only plan out our actions, but they actually anticipate unexpected disturbances.

Learn more: news.westernu.ca/2025/10/sens...

Awww! Thanks! You are always such a sweetheart!

Blue Jays pitcher walking off mound while Dodger batter not yet finished his strike swing.

Go Jays go!