Hanna Degefu

Brand New #FITdb (fitdb.lji.org) tool now LIVE! Do you have a list of genes? You can use "Compare My Geneset" to test if these are overly-represented among functional regulators of T cells across more than 60 conditions! @lji.org supported and developed by Kevin Kim, Xinjian Cen and Harrison Ma.

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity Memory CD8+ T cells have differential cytotoxic capacities across human tissues.

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity

www.science.org/doi/10.1126/...

The endogenous antigen-specific CD8+ T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments The polyclonal CD8+ T cell response to a single antigen is the average of several hundred individual T cell clonotypes. Abdullah et al. demonstrate that most clonotypes exhibit TCR-intrinsic differentiation biases toward memory or effector fates and are…

Online now: Online now: The endogenous antigen-specific CD8+ T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments

The Dartmouth Cancer Center is recruiting a Scientific Director for our Immune Cellular Therapy Program. It is amazing opportunity for an MD/OD to work in a beautiful part of the country at the only NCI-designated Comprehensive Cancer Center in northern New England. Info on applying here:

YouTube video by Association of American Universities Facilities and Administrative (F&A) Costs Explainer

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social

Please share widely!

www.youtube.com/watch?v=yxTD...

Congrats to all award recipients from our meeting, T Cell Differentiation in Tissue Microenvironments/Innate Immune Memory! #KSTCells25 #KSInnateImmune25 @ostunilab.bsky.social @delgoffelab.bsky.social @thelundlab.bsky.social @drshrutinaik.bsky.social @labfairfax.bsky.social @ostunilab.bsky.social

Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8+ T cells
www.cell.com/cell-reports...
@cp-cellreports.bsky.social

Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11

wellcomeopenresearch.org/articles/9-3...

Excited to share our single-cell study on aging mouse brain! We found 2,449 cell-type specific age-DE genes, and an aging hotspot in specific hypothalamic cell types involved in energy homeostasis, which show both decreased neuronal function and increased immune response. doi.org/10.1038/s415...

scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling
www.biorxiv.org/content/10.1...

I’m always looking for things that explain a lot but that people have a hard time remembering.

Examples: Air is stuff. Pee comes from blood. All land vertebrates have a single common ancestor. Venus is bright enough to cast visible shadows. Clouds are heavy. Bones are alive.

Any others you know?

Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer Key Points. IV anti-CD45.2 label lasts for 3 days and tracks leukocyte migration to tissue.There is continuous innate and adaptive leukocyte migration in a

39 rotations around the sun! And what a year it's been. The lab has doubled in size. We had our first (3!!!) graduate students and post docs join the lab. We had both our first and second lab papers EVER accepted - the first is out in print... so check it out -(journals.aai.org/jimmunol/art...).

Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence
www.cell.com/immunity/ful...
@cp-immunity.bsky.social

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Integrative mapping of human CD8+ T cells in inflammation and cancer - Nature Methods scAtlasVAE is a deep learning-based model for cross-atlas integration. Here it enables the development of a large-scale human CD8+ T cell atlas with integrated T cell receptor data.

Integrative mapping of human CD8+ T cells in inflammation and cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity - Nature Aging Exploring how aging compromises antitumor immunity, the authors reveal an age-related impairment of cytotoxic CD8+ TRM cells in mouse tumor models and clinical samples. They implicate BFAR signaling a...

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
www.nature.com/articles/s43...

I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.

We’ve jumped on board fully here on 🦋
A starter pack of those working on our favourite cell … the T cell 🥰🙈🥰

If you want an add let us know

go.bsky.app/8B5P25c

🙋🏽‍♀️

Add me please, thanks!

Please add me! Thanks for re-building the community!