Max Benjamin

Study reveals AI’s critical flaw in medical decision-making Large language models excel at answering medical questions but fail to recognize their knowledge gaps, posing risks in clinical applications.

www.news-medical.net/news/2025011...

In a recent study published in the journal Nature Communications, researchers evaluated the metacognitive abilities of popular large language models (LLMs) to assess their suitability for deployment in clinical settings.

😂😂😂👍

Wolters Kluwer’s AI-powered UpToDate Enterprise Edition expands value, enhancements for clinicians and healthcare leaders New release adds AI search, robust analytics, and insights to set the standard for enterprise Clinical Decision Support.

www.wolterskluwer.com/en/news/wolt...

Coming December 9 the Gray Lady is getting a much needed makeover.

Kidney transplant : 30 minutes 😀🕺
“ - Congratulations team , we met insurance requirements. Oops! we did not connect it to the bladder ! Are we gonna get sued?
- You on our own Doc , that’s between you and your lawyer “

YouTube video by Dr. Glaucomflecken No More General Anesthesia

One thing I didn’t expect in the wake of the CEO shooting is the sudden attention on health insurance policy. I have seen this video and the BCBS policy itself go viral on almost every platform. People are waking up. Real lasting change in healthcare is coming. youtube.com/shorts/vWA2a...

Association of Kidney Function with Sodium-Glucose... : Clinical Journal of the American Society of Nephrology LT2i discontinuation in patients with CKD may limit the cardiokidney benefits of SGLT2i in real-world practice. Background The effect of sodium-glucose co-transporter-2 inhibitors (SGLT2i) on cardi...

journals.lww.com/cjasn/fullte...

Large sample , real world data .
Would want to know reasons for discontinuation . In our practice CKD3b,CKD4 patients hitting the panic button after GFR drop 3-4 ml even though they were counseled about a likely drop in the first three months or more.

Calcium ions are central to cell wall stability and signaling. Mangroves regulate Ca²⁺ uptake and use it to counteract the toxic effects of excess sodium and chloride ions.

Potassium is an essential nutrient for plant metabolic processes and is actively retained by mangroves. K⁺ helps maintain osmotic balance and enzyme activity, particularly in salt-stressed environments.

Mangroves ion management: Chloride ions are mostly excluded or compartmentalized along with sodium to minimize their toxic effects. Mangroves store Cl⁻ in vacuoles to prevent cellular damage.

Aquaporin activity in mangroves can be modulated based on environmental conditions, such as salt stress or waterlogging. Aquaporins can increase their activity in highly saline conditions to prevent water loss or excessive salt intrusion.

By regulating water movement, aquaporins contribute to maintaining cell turgor and osmotic balance

Do mangroves have Aquaporins ? Yes !

Aquaporins help mangroves efficiently absorb freshwater from the soil, even when surrounded by saline water. They allow selective water transport while minimizing salt intrusion, working in tandem with mechanisms like salt exclusion at the roots.

Water management by mangroves through their ability to maintain favorable osmotic gradients through the accumulation of organic solutes within their cellular matrix. This biochemical adaptation enables freshwater extraction from high saline environments .

The third mechanism involves compartmentalization, where excess salt is sequestered in sacrificial tissues like senescent leaves and bark, which the plant periodically shed.

The second mechanism of salt management is through specialized foliar glands that actively secrete excess salt, which be seen as crystalline deposits on leaf surfaces that are subsequently removed by the wind or precipitation .

Salt management capabilities of mangroves operate through three main mechanisms. The first line of defense are their highly specialized root membranes, which are capable of selective permeability. Root membranes filter incoming water, excluding 90-95% of dissolved sea salts .

Mangroves salt and water handling:

Mangrove have evolved sophisticated mechanisms to overcome the challenges of salinity and waterlogged conditions that have proven lethal to most terrestrial vegetation.

I was not kayaking.The kayaking station is half a mile south of where we were . Yes,great kayaking place! The park is the Anne Kolb Nature Center on the Hollywood intracoastal. NephJC yearly animal house podcast inspired me to look at how many life forms maintain homeostasis.

Hollywood Florida yesterday.

The nephrologist return visit to the mangroves, the esteemed experts in sodium and water handling .

AI algorithm matches potential volunteers to clinical trials release Such an algorithm may save clinicians time and accelerate clinical enrollment and research.

www.techexplorist.com/ai-algorithm...

“A recent study found that TrialGPT could successfully identify eligible clinical trials for a given patient summary and provide an explanation for how the patient meets criteria for study enrollment.”

YouTube video by Manlio De Domenico Complexity Thoughts

Why #ComplexitySci is fascinating?

#ComplexSystems are ubiquitous!🧬🦠🧫🔬🐠🦜🧠🌪️🧪
And provide an analytical framework to study the behavior of phys, bio, eco, human & artificial systems #AcademicSky

Curious? I write about them 👉 #ComplexityThoughts: manlius.substack.com

www.youtube.com/watch?v=G8Sv...

YouTube video by MomentsofFlix The Wonderful Story of Henry Sugar #fantasy #comedy

youtube.com/shorts/GM6dl...
The great escape, from a world grown cynical, to the wonderful story of Henry Sugar. Wes Anderson eccentric cinema,2023 ( If only for the lab coats)