Jungsu Kim

J&J's $5B Alzheimer's hope fades as anti-tau antibody posdinemab flops in phase 2 Johnson & Johnson’s attempt to develop a $5 billion-a-year Alzheimer’s disease drug has been rocked by a phase 2 flop. | Johnson & Johnson’s attempt to develop a $5 billion-a-year Alzheimer’s disease ...

J&J's $5B Alzheimer's hope fades as anti-tau antibody posdinemab flops in phase 2
www.fiercebiotech.com/biotech/jjs-...

NIH grant limits rile biomedical research community - Nature Scientists are split over whether limiting grant support to individuals will help young researchers or hurt collaboration.

This reminds me of the 21-point system that the NIH abandoned at the last moment.
As I said in 2017 ("Despite his good fortune, Kim still favours the cap"), I still support a cap. Not sure about which metric will be the most ideal for the "overall" research community.
www.nature.com/articles/nat...

NIH funding
"Consider investigator career stage and promote sustainability of the biomedical research workforce"
"Promote broad distribution and geographic balance of funding, considering the total amount and type of NIH funding already available to each investigator"
grants.nih.gov/grants-proce...

Thanks for sharing, but it appears that CSR is not necessarily mandating a one-day meeting for all study sections.
Just talked with an SRO, and he said that he is still debating options.

Frost lab paper alert! This study was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.... 1/9

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...

Our new review is out today!

𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀

We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.

onlinelibrary.wiley.com/doi/10.1111/...

"Years after Brigham-Harvard scandal, U.S. pours millions into tainted stem-cell field"
www.reuters.com/investigates...
A bit outdated news

Fabricated data in most research fields

Reminds me of the following article
"Why Most Published Research Findings Are False"
journals.plos.org/plosmedicine...

Excited to share the first MRI article from our lab!
Mamun led this work and taught me the approach from the ground up.
So grateful for Mamun's teaching and multiple collaborators, including @btlamb.bsky.social & others not on Bsky, at Stark Neuro Res Inst.

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes INTRODUCTION The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

A very expensive R21 grant paid off well 🤩

Aging doesn't exist “Biological aging,” I fear, is the pseudo-scientific association of societal bias with murky biochemistry.

open.substack.com/pub/andrewms...

Many reviewers didn't bother to submit their critiques even one week past the due date because there will be no study section this week...

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

An interesting behind story.
From a random mutant MOUSE 🐁 model To a HUMAN disease!
Of course, Mouse models can be useful for understanding peripheral immune in Humans too.
www.nobelprize.org/prizes/medic...

The future of universities: A Nature special report The world's universities are under intense pressure. Nature examines the threats they face and asks how the sector can and must adapt to survive.

The future of universities: A Nature special report share.google/CkHwmHHBIU1K...

The undesirable consequences of the growing pressure on faculty to get grants (essay) The increasingly intense pressure on faculty members to get federal grants has produced many undesirable consequences in higher education, argue Gordon G. Gallup Jr. and Bruce B. Svare.

www.insidehighered.com/views/2016/0...
Hijacked by an External Funding Mentality
The increasingly intense pressure on faculty members to get federal grants has produced many undesirable consequences in higher education, argue Gordon G. Gallup Jr. and Bruce B. Svare.

"But given the growing emphasis on funding in many quarters as the sine qua non of academic achievement, we may reach the point where faculty members' obituaries will read along the lines of, "Professor X didn't leave much of an intellectual legacy, but he/she sure brought in a lot of grant money""

Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.

"FlyBase’s now-uncertain future highlights just how interconnected and interdependent research efforts are and how the effects of funding cuts to one institution can ripple worldwide. More than 4,000 labs use FlyBase."
share.google/vYzdfRwVpnHb...

Nevertheless, these two brief papers in BBRC, although not viewed as potentially seminal in the months after their publication, turned out to provide both the factual and conceptual underpinnings for all subsequent research on β-amyloidosis in AD
By Masters & Selkoe
pubmed.ncbi.nlm.nih.gov/22675658/

Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research The budget proposal outlines the additional funding needed in FY27 to advance NIH-supported research toward achieving the goals outlined by the National Plan to Address Alzheimer’s Disease.

🤩Additional funding for AD & ADRD
Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research
www.nia.nih.gov/about/budget...

Reproducibility and Best Practices in Cell Biology
rupress.org/jcb/collecti...

A study of gene expression in the living human brain - Molecular Psychiatry Molecular Psychiatry - A study of gene expression in the living human brain

🤯 Postmortem vs Living brain
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...

"it’s hard for me to believe that damaging the greatest biomedical research system in the world is the way to solve any problems, let alone the problem of antisemitism."

End the unchecked growth of publishing fees and the overreliance on unpaid peer review High publishing costs and a crumbling peer review infrastructure are symptoms of deeper structural issues in research.

End the unchecked growth of publishing fees and the overreliance on unpaid peer review
A proposed NIH policy to limit allowable publication costs is a good start — but more must be done
Peer reviewers should be paid for their considerable labor | STAT share.google/YXf4iuUCa9Zp...

NIH chief calls for immediate research review, dangling threat of project termination Jayanta Bhattacharya, M.D., Ph.D., director of the National Institutes of Health (NIH), has called on the agency’s scientific leadership to immediately review all of their current and planned resea | ...

NIH chief calls for immediate research review, dangling threat of project termination
By Darren Incorvaia
Aug 15, 2025 3:53pm
www.fiercebiotech.com/research/nih...

"hyperphosphorylated tau PREVENTS the age-related decline in whole-body metabolism by preserving glucose tolerance and mitigating shifts in fuel utilization (respiratory exchange ratio; RER),"

😡 The amount of bureaucratic barriers being thrown up for me to host an URM student from an urban high school and pay her a small stipend so she can afford to take this opportunity is making me absolutely stabby. Barriers to participation in STEM are real and undiminished.

Top-down and bottom-up neuroscience: overcoming the clash of research cultures - Nature Reviews Neuroscience As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research app...

Top-down and bottom-up neuroscience: overcoming the clash of research cultures | Nature Reviews Neuroscience share.google/WVex5VystbkH...

I really liked this systems pharmacology approach.

I appreciate your insights regarding the clinical implications, given your expertise as a clinician!

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

Highly recommend everyone take a look!

I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍

Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
www.cell.com/cell/fulltex...