Jungsu Kim

"hyperphosphorylated tau PREVENTS the age-related decline in whole-body metabolism by preserving glucose tolerance and mitigating shifts in fuel utilization (respiratory exchange ratio; RER),"

😡 The amount of bureaucratic barriers being thrown up for me to host an URM student from an urban high school and pay her a small stipend so she can afford to take this opportunity is making me absolutely stabby. Barriers to participation in STEM are real and undiminished.

Top-down and bottom-up neuroscience: overcoming the clash of research cultures - Nature Reviews Neuroscience As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research app...

Top-down and bottom-up neuroscience: overcoming the clash of research cultures | Nature Reviews Neuroscience share.google/WVex5VystbkH...

I really liked this systems pharmacology approach.

I appreciate your insights regarding the clinical implications, given your expertise as a clinician!

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

Highly recommend everyone take a look!

I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍

Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
www.cell.com/cell/fulltex...

Funding crisis hits US ageing research - Nature Shortfalls hamper scientists' efforts to address a predicted epidemic of age-related diseases.

More than a decade-old story, but it resonates again now.
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now

Better Together: ORCID and Other Researcher Identifiers - The Scholarly Kitchen This post is based on a recently-published white paper by Alice Meadows and Josh Brown of MoreBrains Cooperative, in which they discuss why ORCID iDs work best in combination with other researcher ide...

Better Together: ORCID and Other Researcher Identifiers
scholarlykitchen.sspnet.org/2025/07/16/b...

American Association of University Professors calls on Duke to 'immediately halt' its employee buyout program The statement, signed by AAUP president Todd Wolfson, alleges that Duke did not consult faculty and staff in decision-making prior to rolling out the VSIP and has not been transparent with its cost-cu...

"It also calls on Duke’s highest paid administrators and athletic personnel — those making over $500,000 — to consider voluntary, temporary pay cuts to offset the costs of a reduced budget, as opposed to laying off staff."
www.dukechronicle.com/article/2025...

In immunology, for instance, experiments can only be done in vivo to capture the complex interactions of multiple cell types, cytokines and chemokines. No computer will predict immune subsets and mediators that we do not fully understand yet.

Screengrab: "Though these alternative approaches exist, and advances are being made every day, research with animals continues to be essential for understanding human diseases, biological processes, and developing treatments. Alternative approaches cannot completely replace the use of animals at this time. The alternatives simply cannot accurately replicate or model all the biologic and behavioral aspects of human disease. Until that time, animal models will remain integral for live-saving NIH-supported research. However, NIH and NIH funded scientists are continually working to reduce animal use and improve the welfare for animals that are essential for scientific progress."

NIH was already pushing and investing in NAMs before this but had concluded, "Alternative approaches cannot completely replace the use of animals at this time."

grants.nih.gov/policy-and-c...

"Authors may NOT use NIH funds to pay for a right or a license to submit their Author Accepted Manuscripts to PMC to comply with the Policy. The Policy states if an author is asked to pay a fee for submission of the Author Accepted Manuscript to PubMed Central, such costs are not allowable."
🤔🤔🤔

"Publishing with journals that do NOT make their content immediately, publicly available is allowed, as long as the Author Accepted Manuscript is submitted to PMC upon acceptance, for public availability without embargo upon the Official Date of Publication."
🤔🤔🤔
grants.nih.gov/faqs#/public...

"Accumulation of Aβ should not be regarded as a benign consequence of aging; these findings support the amyloid-cascade hypothesis and suggest that therapies aimed at reducing Aβ may be of relevance for the older population."

"In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries"

Keywords: Common!!!

Toward Science‐Led Publishing Click on the article title to read more.

Publishing industry

"We argue that financial motivations central to most publishing distort how research is presented, how it is assessed and even what research is undertaken, leading to a system that hinders, rather than facilitates, scientific progress."
onlinelibrary.wiley.com/doi/full/10....

A good point!!!
Imagine what biomedical researchers could have done with $179 million.

Met him once briefly at a conference this year
(I have known his outstanding work for years, though.)
Please support his lab

Why did you even ask that question in the first place? 😂🤣

This reminds me of the controversial hypothesis that microRNAs in the plants and animals we eat regulate our gene expression.

President Trump has slashed funding for medical research, threatening a longstanding alliance between the federal government and universities that helped make the U.S. the world leader in medical science. Here are the nearly 2,500 grants that have been canceled or delayed. https://trib.al/iBstU2B

That is an unbelievable action by Colombia. 😡😡😡😡😡
I am so sorry for you and many of your colleagues there.

Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia - npj Dementia npj Dementia - Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia

Excited to share our first publication in @npjdementia from #TanseyLab2and3ptO by Mackenzie Bolen & team in collaboration with Zach McEachin @emorygenetics.bsky.social Marla Gearing @emorycnd @melissamurray.bsky.social @mayojax www.nature.com/articles/s44...

What?!? Am I understanding this correctly? Is Columbia saying, "Go find funding, or you're fired"??? No way!

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…

What does the APOE 'lipid droplet-ome' look like???

Check out our new paper to find out!
www.sciencedirect.com/science/arti...

Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social

+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

See How Faculty Pay Varies by Discipline. How Does Yours Stack Up? No field kept up with inflation, but some are faring better than others.

The Faculty Salary Divide
See how pay varies by discipline. How does your field stack up?
www.chronicle.com/article/how-...

So ridiculous! Terribly sorry for him😕

Remember that time Trump got COVID (before the vaccines), and his life was saved by an experimental new monoclonal antibody therapy created using a revolutionary mouse technology invented by a former Assistant Professor at Columbia University?

Neuroscience needs to empower early-career researchers, not fund moon shots Large-scale projects run the risk of stifling scientific independence. Instead, let’s explore alternative mechanisms of collaboration.

"Neuroscience needs to empower early-career researchers, not fund moon shots"

"Large-scale projects run the risk of stifling scientific independence. Instead, let’s explore alternative mechanisms of collaboration."

www.thetransmitter.org/funding/neur...

The 5th International Research Conference on Neurodegenerative Diseases

Please join us!

During oral presentations by trainees, we will have only that session.

When the invited PIs present, we will have concurrent sessions.

All trainees are plenary speakers😍

gasnd.org/ircnd/2025/i...

Different anti-amyloid antibodies have different in vitro binding characteristics to different synthetic Aβ aggregates, leading to the assumption that they bind different species in the human brain. Lecanemab is hypothesized to bind "protofibrils," but these are not well-characterized in human brain

New R01 😍😍😍
Congrats 👏 👏 👏