Bruno A. Benitez

How Are Synaptic Vesicle Exocytosis and Endocytosis Affected in Parkinson Disease? - PubMed Synaptic vesicle exocytosis and endocytosis are 2 fundamental processes that involve the coordinated and timely activity of many proteins and protein-lipid interactions. Alpha-synuclein (α-Syn) regulates several steps of these processes. Impaired exocytosis and endocytosis are important consequences …

How Are Synaptic Vesicle Exocytosis and Endocytosis Affected in #Parkinson Disease? pubmed.ncbi.nlm.nih.gov/41707111/

Ferroptosis induces heterogeneous death profiles that are controlled by lysosome rupture Ferroptosis is a lipid peroxide-dependent form of cell death that occurs in degenerative conditions and may be leveraged for cancer therapy. Although …

Ferroptosis induces heterogeneous death profiles that are controlled by #lysosome rupture www.sciencedirect.com/science/arti...

TMEM106B deficiency exacerbates α-synuclein aggregation in Parkinson’s disease Meng et al. show that deficiency of the lysosomal transmembrane protein TMEM106B contributes to Parkinson’s disease pathogenesis by accelerating α-synuclei

TMEM106B deficiency exacerbates α-synuclein aggregation in #Parkinson's disease academic.oup.com/brain/advanc...

Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux Human pancreatic cancer cells sense specific components of the ECM to fine-tune their autophagy flux levels, conferring the ability to coordinate proliferation, survival, and responsiveness to chemoth...

I wonder if this happens in #neurodegeneration? Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux: Cell www.cell.com/cell/fulltex...

Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes www.biorxiv.org/content/10.6...

Biofluid biomarkers in Alzheimer’s disease and other neurodegenerative dementias - Nature Improved technologies facilitate the detection of molecules linked to neurodegenerative brain changes at very low concentrations in the blood, complementing the clinical evaluation of suspected neurod...

Biofluid biomarkers in Alzheimer’s disease and other neurodegenerative dementias www.nature.com/articles/s41...

Intersections between proteostasis and immunity: insights from Caenorhabditis elegans Summary: Discoveries from the nematode C. elegans have provided insight into the many connections between immune responses and proteostasis, with examples of conservation across species.

Intersections between proteostasis and immunity: insights from Caenorhabditis elegans journals.biologists.com/dmm/article/...

FEBS Press Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n...

Proteostasis of organelles in aging and disease - Nabawi - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1111/...

TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1 During starvation, TFEB activates SQSTM1-dependent autophagy to degrade ubiquitinated ribosomal components.

TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1 | Science Advances www.science.org/doi/10.1126/...

The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...

The #Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in #microglia www.nature.com/articles/s41...

Non-canonical roles of lysosomes in neurons Neurons are highly polarised and compartmentalised cells with organelles that are specialised to support their spatial and functional demands. This includes lysosomes, which are single-membrane-bound ...

Non-canonical roles of #lysosomes in neurons: Trends in Neurosciences www.cell.com/trends/neuro...

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases In the last two decades, many gene mutations have been identified that when homozygous, lead to childhood neurological disorders, but when heterozygou…

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases www.sciencedirect.com/science/arti...

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases - PubMed In the last two decades, many gene mutations have been identified that when homozygous, lead to childhood neurological disorders, but when heterozygous, result in adult-onset neurodegenerative disease. A shared feature linking these genes? They encode proteins residing in or impacting the function o …

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases pubmed.ncbi.nlm.nih.gov/41253210/

Failure of lysosomal acidification and endomembrane network in neurodegeneration - Experimental & Molecular Medicine Lysosomes are now known to play important roles in cell signaling and maintaining balance within cells. This Review explores how lysosomes interact with other cell parts and their role in diseases suc...

Failure of lysosomal acidification and endomembrane network in neurodegeneration www.nature.com/articles/s12...

Inhibition or genetic reduction of ASAH1/acid ceramidase restore α-synuclein clearance in mutant GBA1 dopamine neurons from Parkinson’s patients Abstract. Bi-allelic mutations in GBA1, a gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase), cause Gaucher disease (GD). Although GD carr

Inhibition or genetic reduction of ASAH1/acid ceramidase restore α-synuclein clearance in mutant GBA1 dopamine neurons from #Parkinson’s patients academic.oup.com/hmg/advance-...

Highly recommended review. "recent convergence of large-scale biobanks, #multi-omics data and computational methods, including machine learning, has led to advances in #genetics-driven drug discovery, offering new opportunities to refine target selection and reduce late-stage risk"

Leveraging Proteomics to Explore the Molecular Mechanisms of Primary Tauopathies Primary tauopathies are a group of neurodegenerative diseases characterised by the aggregation of tau in the brain. In these diseases, little is known about the molecular mechanisms driving neurodege....

Leveraging #Proteomics to Explore the Molecular Mechanisms of Primary Tauopathies - Nementzik - 2025 - Journal of Neurochemistry - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Proteomic subtyping of Alzheimer's disease CSF links blood–brain barrier dysfunction to reduced levels of tau and synaptic biomarkers INTRODUCTION Alzheimer's disease (AD) shows clinical and molecular heterogeneity shaped by demographic and genetic factors. METHODS To resolve this heterogeneity, we performed a network-based prot...

Proteomic subtyping of #Alzheimer's disease CSF links blood–brain barrier dysfunction to reduced levels of tau and #synaptic biomarkers - Bangs - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co‐Cultured Neurons Loss-of-function progranulin (GRN) mutations cause frontotemporal dementia. Most of these mutations cause haploinsufficiency of progranulin, a secreted pro-protein that has neurotrophic and anti-infl...

Delivering Progranulin to Astrocytic #Lysosomes Promotes Growth of Co‐Cultured Neurons - Kaplelach - 2025 - Journal of Neurochemistry - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila Most Alzheimer disease (AD) susceptibility genes have poorly understood roles in the central nervous system (CNS). To address this gap, we systematica…

Revealing the nervous system requirements of #Alzheimer disease risk genes in Drosophila www.sciencedirect.com/science/arti...

Proteomics to Transform Parkinson’s Disease: Mechanisms, Biomarkers, and Therapeutic Targets Proteomics that elucidates PD mechanisms, provides reliable CSF and plasma biomarkers, and supports targeted therapies across the brain, cells, and overtime.

Proud to guest edit an npj Parkinson’s Disease Collection: “Proteomics to Transform Parkinson’s Disease.” Submissions open through 27 Jul 2026. Details & submit: www.nature.com/collections/...
#Parkinsons #Proteomics #PDResearch

Proteomics Insights Into Lysosome Biogenesis and Maturation Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They p....

Proteomics Insights Into #Lysosome Biogenesis and Maturation analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

The space-time continuum in neurological disorders of the autophagosome-lysosome fusion machinery Autophagy is a highly conserved cellular pathway for the degradation and recycling of defective intracellular cargo and plays a vital role in the homeostasis of post-mitotic tissues, particularly t...

The space-time continuum in neurological disorders of the #autophagosome-#lysosome fusion machinery www.tandfonline.com/doi/full/10....

Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders Lysosomes maintain cellular homeostasis by degrading proteins delivered via endocytosis and autophagy and recycling building blocks for organelle biogenesis. Lysosomal Storage Disorders (LSDs) compris...

Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons across #Lysosomal Storage Disorders by the Harper Lab at @harvardcellbio.bsky.social www.biorxiv.org/content/10.1...

APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation Abstract. Amyloid precursor protein (APP), a type I transmembrane protein, is closely related to the pathogenesis of Alzheimer’s disease (AD). Amyloid beta

APP ubiquitination by VHL protein is essential for MVB sorting and #lysosomal degradation academic.oup.com/jmcb/advance...

EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling

EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects by Dr. Bonifacino lab at NIH academic.oup.com/brain/advanc...

LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a murine Alzheimer’s disease model by reprogramming microglia Translational Psychiatry - LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a murine Alzheimer’s disease model by reprogramming microglia

LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a murine Alzheimer’s disease model by reprogramming microglia ... 🤔 rdcu.be/eJRBe

Elevated tripeptidyl-peptidase 1 corrects multiple disease phenotypes in a mouse model of juvenile neuronal ceroid lipofuscinosis Juvenile neuronal ceroid lipofuscinosis (JNCL) is an untreatable, fatal neurodegenerative lysosomal disease. Sleat and colleagues have shown that increased levels of tripeptidyl-peptide 1 attenuates d...

Elevated tripeptidyl-peptidase 1 corrects multiple disease phenotypes in a mouse model of juvenile neuronal ceroid lipofuscinosis: Molecular Therapy Methods & Clinical Development www.cell.com/molecular-th...

Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early‐Onset Parkinsonism Objective Autophagy is a fundamental biological pathway with vital roles in intracellular homeostasis. During autophagy, defective cargoes including mitochondria are targeted to lysosomes for cleara.....

Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early‐Onset Parkinsonism - Dafsari - Annals of Neurology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

APP family is a regulator of endo-lysosomal membrane vulnerability The amyloid precursor protein (APP) is cleaved by β- and γ-secretases, resulting in the generation of β-amyloid (Aβ). Aβ peptides accumulate in the brain of Alzheimer’s disease (AD), and the removal o...

APP family is a regulator of endo-lysosomal membrane vulnerability www.jbc.org/article/S002...