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Levayer Lab

@levayerr.bsky.social

Epithelial cell death, cell extrusion, self-organisation, mechanotransduction and many other things

3,369 Followers  |  487 Following  |  162 Posts  |  Joined: 06.12.2023
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Posts by Levayer Lab (@levayerr.bsky.social)

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).

A brief 🧡 (carried over from the old place)

28.02.2026 08:12 β€” πŸ‘ 242    πŸ” 94    πŸ’¬ 12    πŸ“Œ 5
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Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental condi...

Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate www.nature.com/articles/s41... #jcampubs

25.02.2026 17:06 β€” πŸ‘ 49    πŸ” 22    πŸ’¬ 0    πŸ“Œ 2
ShineGAL4 FLP-out clones

ShineGAL4 FLP-out clones

#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social

@dev-journal.bsky.social
tinyurl.com/4jpw9jd6

25.02.2026 16:03 β€” πŸ‘ 43    πŸ” 23    πŸ’¬ 1    πŸ“Œ 2
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Impaired stem cell migration and divisions in Duchenne muscular dystrophy revealed by live imaging - Nature Communications Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...

Bravo Liza, Brendan and colleagues for the elegant work on multiple live imaging strategies to untangle mechanisms of muscular dystrophy! www.nature.com/articles/s41...

21.02.2026 13:05 β€” πŸ‘ 19    πŸ” 11    πŸ’¬ 1    πŸ“Œ 1
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Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation Bosveld et al. identified a multilayered system of safeguards that reuses homeostatic mechanisms to maintain epithelial integrity and cell number in the face of spindle misorientation. This work delin...

How resilient are tissues to cell mispositioning and loss, and how do they restore their cell numbers?

Check our latest work, from @ybellaichelab.bsky.social
Congratulations to all authors.

Artwork from the artist @lale-alpar.bsky.social
(lalealpar.com)

www.cell.com/developmenta...

17.02.2026 06:31 β€” πŸ‘ 30    πŸ” 16    πŸ’¬ 4    πŸ“Œ 1

Group Leader Call at the @cbitoulouse.bsky.social in
Genome biology, projects at the interface with devbio will be given particular attention. please share :)
cbi-toulouse.fr/wp-content/u...

17.02.2026 16:05 β€” πŸ‘ 28    πŸ” 31    πŸ’¬ 1    πŸ“Œ 0
Santa Cruz Developmental Biology Meeting

Registration is OPEN for the 2026 Santa Cruz Meeting on Developmental Biology!!! Please spread the word!

@mads100tist.bsky.social @socdevbio.bsky.social @bsdb.bsky.social @xenbase.bsky.social @isdb.bsky.social @devbiol.bsky.social @the-node.bsky.social

scdb2026.sites.ucsc.edu

10.02.2026 20:12 β€” πŸ‘ 46    πŸ” 38    πŸ’¬ 1    πŸ“Œ 4

Congrats, it looks very nice, definitly on my reading list !

28.01.2026 22:08 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
System-level regulation of hierarchical transitions in a tumour lineage The fundamental principles defining how cell state transitions are regulated along a tumour lineage to determine its cellular composition remain unclear. Here, we investigate how such transitions are controlled in a reductionist hierarchical brain tumour model. Quantitative analysis of 3D transition maps revealed that the differentiation of cancer stem cells (CSCs) into transit amplifying progenitors (TAPs) depends on the identity of their immediate neighbours. This is embodied in a transition rule that quantitatively predicts the probability to differentiate as a function of the proportion of TAP neighbours. Integrated into 3D simulations of tumour growth, this rule spontaneously recapitulates spatial segregation of CSCs in clusters and their stable proportion. We further show in vivo that CSC clustering protects the CSC pool from depletion driven by TAPs. We identify an EGFR-mediated relay mechanism that propagates the CSC-to-TAP transition across CSC clusters. In CSCs, the LRIG1-like EGFR inhibitor Kekkon1 dampens this propagation, ensuring continuous replenishment of the CSC pool. Collectively, these findings show how local fate regulation drives emergent segregation which in turn constrains CSC differentiation dynamics. This provides a conceptual framework to understand and exploit the tumour’s intrinsic differentiation potential by manipulating the determinants of its system-level features. ### Competing Interest Statement The authors have declared no competing interest. Turing Centre for Living Systems (CENTURI) La Ligue Contre le Cancer, https://ror.org/00rkrv905, Equipe LabellisΓ©e LIGUE 2025 Fondation pour la Recherche MΓ©dicale, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Agence Nationale de la Recherche under the France 2030 program, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Centre South-ROCK, INCa-Cancer_18695

Tumours aren’t just a messy mix of cellsβ€”they’re highly organised and hierarchical societies!
Just like in all societies, small chats between individuals can drive collective emergent behaviours - we reveal how these sustain tumour growth and cellular heterogeneity. πŸ§΅πŸ‘‡

28.01.2026 21:53 β€” πŸ‘ 17    πŸ” 7    πŸ’¬ 2    πŸ“Œ 0

Took advice from @parismarx.com a couple weeks ago and it's been great. Most all changes I've made have zero impact on my day-to-day, but mean I'm supporting a wide diversity of non-US platforms. A couple are even a genuine improvement.

Combat both US tech capitulation and Enshittification at once.

21.01.2026 07:49 β€” πŸ‘ 89    πŸ” 41    πŸ’¬ 5    πŸ“Œ 0
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That's it...that's my post, period.

21.01.2026 07:50 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Maybe one of my favourite cover (and this you can only find in @currentbiology.bsky.social ). Loved the broom experiment.

20.01.2026 11:43 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We’re hiring!
@jcellsci.bsky.social is looking for a Reviews Editor to join the team. This is a fantastic opportunity for someone who loves #cellbiology and wants to stay connected with the field. A great chance to work for an organisation that believes in helping the community!

Details belowπŸ‘‡

09.01.2026 10:13 β€” πŸ‘ 29    πŸ” 42    πŸ’¬ 1    πŸ“Œ 0
Smart microscopy, computer vision, and controlling cells with light -- my PhD thesis in 3 minutes
YouTube video by Pertz Lab Smart microscopy, computer vision, and controlling cells with light -- my PhD thesis in 3 minutes

Won best thesis award with this video! 4 years of research and play in 3 minutes :')
youtu.be/so0fPlK1-LM

07.01.2026 11:26 β€” πŸ‘ 67    πŸ” 24    πŸ’¬ 12    πŸ“Œ 1
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Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧡 and at www.nature.com/articles/s41... 🀩
@poldresden.bsky.social @mpi-cbg.de

07.01.2026 16:02 β€” πŸ‘ 150    πŸ” 60    πŸ’¬ 8    πŸ“Œ 5
Fluorescence microscopy image of an ovarian follicle (light blue/magenta), with a bright central oocyte.

Fluorescence microscopy image of an ovarian follicle (light blue/magenta), with a bright central oocyte.

πŸ’₯πŸ₯š ANR-funded Assistant Engineer position open in our β€œControl & Dynamics of the Ovarian Cycle” group at IBDM Marseille πŸ‡«πŸ‡·

Work on mouse lines + lab logistics + follicle culture/imaging πŸ”¬

πŸ—“οΈ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U...

Please share widely β€” especially with colleagues in France!

06.01.2026 08:13 β€” πŸ‘ 28    πŸ” 21    πŸ’¬ 1    πŸ“Œ 1
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Happy New Year 2026!

This year, Hadi Boukhatmi, RΓ©gis Giet and I are delighted to be organising the 36th French Droso Meeting in Brittany, from 5 to 8 October.
A great line-up of speakers

Mark the date in your diaries !

The meeting website containing all the details will be opening very soon.

06.01.2026 09:24 β€” πŸ‘ 15    πŸ” 12    πŸ’¬ 0    πŸ“Œ 1
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Biophysics of organoids In this review, Weichselberger, Moore et al. discuss how physics-based approaches illuminate organoid development and homeostasis by integrating mechanical, chemical, and informational processes. They...

Interested in the biophysics of organoids? We just published a review in Dev Cellβ€”take a look! dlvr.it/TPyTb8 #Organoids #Biophysics

06.01.2026 10:27 β€” πŸ‘ 81    πŸ” 26    πŸ’¬ 0    πŸ“Œ 2
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How does signalling control cortical tension?

Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.

More here:
www.biorxiv.org/content/10.6...

Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social

18.12.2025 17:22 β€” πŸ‘ 55    πŸ” 11    πŸ’¬ 0    πŸ“Œ 1
❄️ single cells, single cells! ❄️ #acapella #science #christmas
YouTube video by acapellascience ❄️ single cells, single cells! ❄️ #acapella #science #christmas

I was trying to get in the christmas vibe despite the overwhelming end of the year...but then I bumped into the videos of @acapellascience.bsky.social and I fill much more ready now...
www.youtube.com/shorts/bGqDO...

11.12.2025 20:51 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Mark your calendars! The next SFB 1348 International Meeting will take place in #MΓΌnster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...

27.10.2025 07:00 β€” πŸ‘ 48    πŸ” 32    πŸ’¬ 0    πŸ“Œ 3

Amazing ! Congrat Ina really happy for you and your lab (a lot of exciting dynamics signaling analysis to come)

09.12.2025 13:58 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

πŸ”¬ Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

πŸ“… Deadline: Feb 9, 2026
πŸ‘₯ 2-12 years post-PhD

Apply now πŸ“ research.pasteur.fr/en/call/crea...

#JobOpportunity #Research

08.12.2025 08:53 β€” πŸ‘ 99    πŸ” 137    πŸ’¬ 1    πŸ“Œ 9

Come to be our colleague! Center of Paris, excellent facilities, research spanning the whole range of basic and biomedical life science topics, enthusiastic and collaborative colleagues, crème brûlée every Friday... What else could one want?

08.12.2025 10:56 β€” πŸ‘ 35    πŸ” 31    πŸ’¬ 1    πŸ“Œ 1

Oh no, they are going to experience Lautreculin...😱 (but this is really cool and quite an achievement to bring cytoskeleton there)

05.12.2025 18:37 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en

03.12.2025 08:00 β€” πŸ‘ 35    πŸ” 28    πŸ’¬ 0    πŸ“Œ 6

Reviewing process has always been painfull, but it will just become useless and impossible to publish if we start accepting this (we are not helping science...and better refusing to review if you have no time rather than using these tools without filter)

04.12.2025 08:25 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

It's been several times that I am pretty sure to witness during reviewer crosscommenting assesment mostly generated by AI (composed of hundred of unnecessary and finicky points that would lead to years of revision). For the human reviewer out there, speak up to editor if you notice this !

04.12.2025 08:25 β€” πŸ‘ 15    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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ERC-Plus: jackpot science or missed chance to fix academia? My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…

I just published: ERC-Plus: jackpot science or missed chance to fix academia?

My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.

medium.com/p/erc-plus-j...

03.12.2025 11:42 β€” πŸ‘ 100    πŸ” 62    πŸ’¬ 6    πŸ“Œ 12

I am just afraid how it could be badly used to overfocus on millions of non important details that would make reviewing even worst than it is already...(and to be honnest I suspect I have already seen in crossreviewing reviewer report looking very much like AI style...which is worrying)

03.12.2025 22:08 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0