Cells & Development

Enzymes involved in the biosynthesis pathway of sialic acid, sialic motifs, and sialylated proteins present during cleavage stages in the blastula and blastocyst formation, in embryonic stem cells (ESCs), and during the epithelial-to-mesenchymal transition (EMT) across various species. The production of sialylated proteins follows a multistep pathway derived from the glucose metabolism and occurs across three cellular compartments, ultimately leading to the placement of sialylated proteins in the plasma membrane.

Blastula from various species. The coeloblastula surrounds an inner fluid-filled blastocoel, whereas the stereoblastula shows no cavity. I

It is not often that Sialoglycoproteins and sialyltransferases are mentioned during early development. This interesting review from the lab of Katia Cailliau brings the interesting biology of sialic acid into the context of #devbio, particularly during blastula formation.
doi.org/10.1016/j.cd...

Enzymes involved in the biosynthesis pathway of sialic acid, sialic motifs, and sialylated proteins present during cleavage stages in the blastula and blastocyst formation, in embryonic stem cells (ESCs), and during the epithelial-to-mesenchymal transition (EMT) across various species. The production of sialylated proteins follows a multistep pathway derived from the glucose metabolism and occurs across three cellular compartments, ultimately leading to the placement of sialylated proteins in the plasma membrane.

Blastula from various species. The coeloblastula surrounds an inner fluid-filled blastocoel, whereas the stereoblastula shows no cavity. I

It is not often that Sialoglycoproteins and sialyltransferases are mentioned during early development. This interesting review from the lab of Katia Cailliau brings the interesting biology of sialic acid into the context of #devbio, particularly during blastula formation.
doi.org/10.1016/j.cd...

yep, this is very concerning.

Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...

www.cell.com/patterns/ful...

We love zebrafish too! <3 #FluorescenceFriday #devbio

Happy #FluorescenceFriday. This beautiful video shows slice by slice section of a zebrafish embryo's head. The embryo is almost completely transparent, proving that zebrafish is an amazing model system for microscopy.
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)

This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard

Call for papers: Chilean Developmental Biology: at Home and Around the World - Cells & Development.
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...

🚨✨🐸 Very excited to share the latest work I’m part of:

“Developmental and adult expression of the Meis2 transcription factor in the CNS of Xenopus laevis”.

Read below 👇

DOI: doi.org/10.3389/fnan...

#Neurogenesis #BrainDevelopment #Neuroscience #EvoDevo #DevBio #Xenopus

Meis2 is a transcriptional factor involved in neurodevelopment. This paper characterises its distribution in the developing brain of Xenopus leavis. Check it out!

Sir John Gurdon was also the president of the @isdb.bsky.social from 1989-1992. He also facilitated or influenced the establishment of the @bsdb.bsky.social, @lasdb.bsky.social, many institutes, and generations of scientists, and worked with @biologists.bsky.social for decades. You will be missed.

Sir John Gurdon on the occasion of his 80th birthday. Original portrait by Prof. Nadia Rosenthal of The Jackson Laboratories, pencil on Arches paper. Courtesy of the artist.

"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".

A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...

Sir John Gurdon on the occasion of his 80th birthday. Original portrait by Prof. Nadia Rosenthal of The Jackson Laboratories, pencil on Arches paper. Courtesy of the artist.

"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".

A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...

We love frogs too 🐸!

🐸 Xenopus laevis 💚 The frog that shaped modern developmental biology! ✨ Xenopus embryos have revealed how the body axis forms, cells choose their fate, and tissues self-organize during early development 📹 Video by Bioquest Sudio and Xenbase #ModelMonday #DevBio

From the lab of Maxwell Heiman discussing the interesting topic of apical ECM and the function of sensing organs and how these ECM proteins can both mechanically and biochemically modulate the organ's functions.
doi.org/10.1016/j.cd...

From the lab of Brian Stramer discussing how the ECM actively involved in shaping embryo morphogenesis.
doi.org/10.1016/j.cd...

From the lab of Kenneth Yamada showing how mRNAs coding for basement membrane proteins are polarised apically in mouse embryonic salivary gland outer epithelial cells and are trafficked by microtubules.
doi.org/10.1016/j.cd...

In the spirit 👻 of Freaky Friday 🎃, here is a beautiful yet eery video of zebrafish retina development showing horizontal cells (🔵) finding their way out of the crowded amacrine (🟠) layer to settle beneath the photoreceptors. Happy #Halloween!
🎥: PhD student Rae Wong from the @nordenlab.bsky.social

Adhesion to a common ECM mediates interdependence in tissue morphogenesis in Drosophila For organs to be functional, the cells and tissues that constitute them must effectively interact with each other and coordinate their behaviours. Halfway during Drosophila embryogenesis, two lateral ...

The first original research paper from my lab is now out in @biorxivpreprint.bsky.social! www.biorxiv.org/content/10.1...
Tracheal development is an amazing model to study morphogenesis. There are great works out there that show how this tissue elongates, interconnects, and forms branches (1/n)

The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...

Special issue looking at the relationship between ECM and development. The role of ECM in shaping developmental dynamics is increasingly recognised. Check it out:

From the lab of Chinmoy Patra discussing the importance of ECM in heart morphogenesis and the roles of secreted molecules in mediating fibrosis or regeneration after myocardial injury.
doi.org/10.1016/j.cd...

From the lab of Maxwell Heiman discussing the interesting topic of apical ECM and the function of sensing organs and how these ECM proteins can both mechanically and biochemically modulate the organ's functions.
doi.org/10.1016/j.cd...

From the lab of Jean Schwarzbauer identified IGFBP3 as the most up-regulated gene in fibrotic human lung fibroblasts and can be used as a potential biomarker for idiopathic pulmonary fibrosis.
doi.org/10.1016/j.cd...

From the lab of Eva Matalova exploring the role of TGF-B in gld osteoblastic cells.
doi.org/10.1016/j.cd...

From the lab of @rachellennon.bsky.social showing how fluid flow can alter Collagen IV network architecture using a very neat kidney co-culture system.
doi.org/10.1016/j.cd...

From the lab of Scott Holley showing the distinct functions that fibronectin 1a and 1b have during zebrafish development using live imaging.
doi.org/10.1016/j.cd...

From the lab of Brian Stramer discussing how the ECM actively involved in shaping embryo morphogenesis.
doi.org/10.1016/j.cd...

From the lab of Kenneth Yamada showing how mRNAs coding for basement membrane proteins are polarised apically in mouse embryonic salivary gland outer epithelial cells and are trafficked by microtubules.
doi.org/10.1016/j.cd...

The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...