Philip Ruthig

We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...

Promotional poster for the LMU Open Science Center Summer School 2025 Public Lecture. The poster features a photo of speaker Prof. Dr. Richard McElreath. The text states the lecture focuses on science as amateur software development, time and date of lecture being 9:00-10:00 CEST on Wednesday September 17 2025, and instructions to register online. Logos of LMU Open Science Center, LMU, and Universitätsbibliothek München are displayed at the bottom.

💡 Explore how practices from distributed, open-source software can make science more professional, open, and collaborative! Attend the “Science as amateur software development” lecture by Prof. Dr. @rmcelreath.bsky.social on Wed 17 Sept, 9:00.
👉 Register here: www.pretix.osc.lmu.de/lmu-osc/OSSS...

Wrote the same thing as a tweetorial on X, got a single interaction with the tweet. I guess it is finally time to leave that place for good

😱

Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)

#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy

That leaves me to thank my excellent co-1st author David Edler von der Planitz, and our collaborators and co-supervisors @siawooshmr.bsky.social, @nikweiskopf.bsky.social, Evgeniya Kirilina, and Markus Morawski!

A collaborative project of @mpicbs.bsky.social and @unileipzig.bsky.social!

That concludes the skeetorial - check the full paper @plosbiology.org: plos.io/4mq5tOy

Furthermore, we supply other scientists with the necessary functions that describe our experimental data - important for anyone who might want to simulate brain-wide activity!

Based on this anatomical data, we estimate that corpus callosum fibers conduct signals ~25% faster than short white matter fibers, and show a higher portion of very fast fibers (>8m/s).

In contrast, the g-ratio distribution of both sets of fibers is almost identical!

Additionally, both groups of fibers seems to have a large amount of fibers near the g-ratio of 0.6. This seems to be the equilibrium for long fibers where energy expenditure by the organism, space constraints, velocity and efficiency of signal transduction meet.

We fitted a generalized extreme value function (GEV) to all of the distributions and found that both axon diameter and myelin thickness is downscaled in shorter fibers.

Using a fully automated deep learning analysis, we segmented each structure in the TEM data and analyzed the axonal diameter, myelin thickness, and g-ratio (ratio between axon radius & myelin thickness).

To investigate this issue, we sampled white matter tissue from body donors from a variety of superficial white matter (mostly short fibers) and corpus callosum areas (very long fibers), and prepared them for transmission electron microscopy.

How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning

Out now in @plosbiology.org: our recent study on white matter myelination and axon diameters in long and short fibers of humans! Skeetorial coming soon :)

When a microscope facility user asks about how to make a red/green overlay

Our spin-off company is hiring a COO. (Stay tuned for more job offers)

www.linkedin.com/jobs/view/42...

bsky.app/profile/matt...

Screenshot of the PDF available at https://cloud.gerbi-gmb.de/s/6LrYfMByymPnHP5/download/2025_OME-Zarr_sw_developer.pdf

Screenshot of the PDF available at https://cloud.gerbi-gmb.de/s/y4rBGFM6dXn8Jkr/download/2025_OME-Zarr_web_developer.pdf

🚀 We’re hiring again! Join @gerbi-gmb.de as a Software Developer!

💻 Build scalable #bioimaging solutions

🌍 Collaborate globally

🎯 Contribute to open science through #OME #Zarr

📣 Tell your #NGFF friends.

Remote, full-time. Apply by 30 June 2025: All submissions via bit.ly/gerbi-jobs-2...

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...

Signs I am, indeed, living in Munich, pt 1:

I just paid 9€ for a pretzel and croissant.

Definitely going to, soon!

+1000

I think AI will help us do scientific research in numerous ways, but the bulk of the work that real scientists do is not anything that "AI scientists" will be able to do.

📌

Every now again it’s useful to repeat advice about accessing papers that are behind a paywall that excludes you. Email the author. My estimate is that 90% of academics are so thrilled that a living, breathing, possibly even reading, person shows interest that they will swiftly send you a copy.

One of the undisputed scientific wins of the last few years.

Can wholeheartedly recommend the city, place and people to motivated to-be phd students! Don't hesitate to apply 👏👏

🚀 Now hiring: 10 Doctoral Researchers @ Leipzig University! 🧠🔬

Join the DFG funded RTG NeuroTune and explore how neurons fine-tune communication!
📍 Start: Oct 1, 2025
🎯 Cutting-edge neuroscience + top-tier mentoring in vibrant Leipzig.

Apply now 👉 www.lw.uni-leipzig.de/en/institut-...
#NeuroTune

Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates - Nature Communications There are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a ra...

BREAKING: Development of a spike protein-specific radiolabeled antibody used with PET imaging shows presence of spike in brain & lungs of macaque monkeys 3 months post-COVID; provides new viral reservoir detection opportunity for long COVID: www.nature.com/articles/s41...