Dustin Scheinost

Brain Activity is Increasingly Variable During Development Fluctuations in brain activity increase until mid-adolescence. Deviations from this trajectory are linked to worse executive functioning.

In a recent @cp-neuron.bsky.social study, @dscheinost.bsky.social and @yaleschoolofmed.bsky.social's Jean Ye found that neural variability 🧠—brain fluctuations that support flexible behavior—increases 📈 through childhood 👶before stabilizing in adolescence🧍

03.10.2025 13:38 — 👍 2    🔁 1    💬 0    📌 0

Variation in moment-to-moment brain state engagement follows a consistent trajectory during development Neural variability, or variation in brain signals, facilitates dynamic brain responses to ongoing demands. This flexibility is important during develo…

This developmental trajectory is consistent across four datasets, with deviations from this trajectory associated with poorer executive function. Girls also peaked earlier than boys. @yalebiomedimaging.bsky.social @yaleschoolofmed.bsky.social

sciencedirect.com/science/arti...

24.09.2025 15:45 — 👍 2    🔁 1    💬 0    📌 0

Excited to share our work now out in @cp-neuron.bsky.social !!! We found that during development, people become more variable in how much they engage recurring brain states.

24.09.2025 15:45 — 👍 2    🔁 0    💬 1    📌 0

Very excited for this review to be out! A dive into PET/MRS techniques for measuring brain glucose concentrations and cerebral metabolic rate of glucose in the context of diabetes and obesity. #neuroimaging #obesity #diabetes #metabolism #neuroendocrinology

link.springer.com/article/10.1...

28.07.2025 17:01 — 👍 8    🔁 3    💬 1    📌 0

Screenshot of paper titled "Modality-level obstacles and initiatives to improve representation in fetal, infant, and toddler neuroimaging research samples" with authors: Emma T. Margolis, Paige M. Nelson, Abigail Fiske, Juliette L.Y. Champaud, Halie A. Olson, Maria José C. Gomez, Áine T. Dineen, Chiara Bulgarelli, Sonya V. Troller-Renfree, Kirsten A. Donald, Marisa N. Spann, Brittany Howell, Dustin Scheinost, and Marta Korom.

It is more important than ever to promote inclusive & representative science as best scientific practice. In this new paper, we highlight modality-level (MRI, MEG, EEG, fNIRS, ultrasound) obstacles & initiatives for improved inclusivity in FIT neuroimaging. doi.org/10.1016/j.dcn.2024.101505

14.02.2025 19:43 — 👍 13    🔁 8    💬 1    📌 1

Opioid use disorder might lead to ‘sticky’ brains Individuals with opioid use disorder were less able to flexibly engage different patterns of brain activity, Yale researchers found.

📢 In a new study, @yaleschoolofmed.bsky.social's Jean Ye, @evgoldfarb.bsky.social, & @dscheinost.bsky.social found that people with opioid use disorder had less cognitive flexibility in engaging different brain states 🧠after viewing opioid-related images💊📷

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29.01.2025 17:32 — 👍 1    🔁 1    💬 0    📌 0

Modality-Level Obstacles and Initiatives to Improve Representation in Fetal, Infant, and Toddler Neuroimaging Research Samples Fetal, infant, and toddler (FIT) neuroimaging researchers study early brain development to gain insights into neurodevelopmental processes and identif…

Happy New Year! The first working day of 2025 is off to a FANTASTIC start, with news that our paper with the FITNG Trainee Committee @fitngin.bsky.social has been accepted for publication in DCN! Wahooooooo 🥳 www.sciencedirect.com/science/arti...

06.01.2025 11:59 — 👍 3    🔁 3    💬 0    📌 0

Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder This case-control study compares functional magnetic resonance imaging data from individuals with opioid use disorder (OUD) and healthy control participants to examine whether individuals with OUD hav...

Thrilled to share Jean Ye’s latest paper on brain dynamics in opioid use disorder (OUD), using resting-state, task-based, and naturalistic fMRI! Check it out at Jama Network Open: jamanetwork.com/journals/jam...

22.01.2025 14:28 — 👍 1    🔁 1    💬 1    📌 0

Altered Brain Dynamics Across Bipolar Disorder and Schizophrenia During Rest and Task Switching Revealed by Overlapping Brain States Individuals with bipolar disorder (BD) and schizophrenia (SCZ) show aberrant brain dynamics (i.e., altered recruitment or traversal through different brain states over time). Existing investigations o...

We found reduced brain state flexibility in OUD, with inflexible dynamics linked to lower cognitive control—especially after viewing opioid-related images. Curious about our brain state flexibility methods? See
Jean’s previous work for details: www.biologicalpsychiatryjournal.com/article/S000...

22.01.2025 14:28 — 👍 0    🔁 0    💬 0    📌 0

Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder This case-control study compares functional magnetic resonance imaging data from individuals with opioid use disorder (OUD) and healthy control participants to examine whether individuals with OUD hav...

Thrilled to share Jean Ye’s latest paper on brain dynamics in opioid use disorder (OUD), using resting-state, task-based, and naturalistic fMRI! Check it out at Jama Network Open: jamanetwork.com/journals/jam...

22.01.2025 14:28 — 👍 1    🔁 1    💬 1    📌 0