Soumen Basak

One may demand increased usefulness of animal experiments, but to stop funding for grants with only animal experiments may not bring any value for either animal well-being (for the point you mentioned) or for human health (organoids will be ineffective in capturing multi-organ crosstalk).

Time to transmute and grow even more.

A graphic showing the GlycoCaging approach

“GlycoCaging” uses gut bacteria to activate drugs for inflammatory bowel disease.

Learn more in a new #SciencePerspective: scim.ag/4ltfMk8

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

www.science.org/doi/10.1126/...

Completing the circuit? Enteric neurons produce immunomodulatory neuropeptides. It seems that they also express cytokine receptors and that cytokine signals promote neuropeptide production by them. The study shows the importance of this crosstalk in helminth control.

Students:
Reading is not a project. Definitely not a summer project.
That's what students do.
Just like breathing is what living organisms do.
@treelab.bsky.social there are no reading projects, but you can borrow books, or we can direct you to the aisle in the #iiserbhopal library.

Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry Community-suggested best practices for the analysis of oxylipins are presented.

🧪 Almost 100 researchers across 70 institutions, including academia, industry, and clinical laboratories, have developed new recommendations for analyzing oxylipins by LC-MS/MS. Hopefully, these guidelines will improve reproducibility in research. Read their article this week in Science Signaling:

Gene behind orange fur in cats found at last After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do

After 60 years, scientists finally know why ginger, calico, and tortoiseshell cats look the way they do. scim.ag/3BpxRxY

Trace DNA from kill sites identifies individual predators Predation ecology and evidence-based conflict management strategies require reliable and accurate identification of individual predators. Identifying …

#NewPublicationAlert
Himanchu Chattani & team from Prof Uma Ramakrishnan's lab present a method to identify predators using non-invasive genetic samples from kill sites.
Read here: bit.ly/3RO6T84

🎉Congratulations to the team!

Hi

Global pandemic treaty finalized, without U.S., in ‘a victory for multilateralism’ Three years in the making, the accord aims to increase equity and avoid errors of the COVID-19 pandemic

It took an extension to the extension of the extension, but after more than 3 years of negotiations, governments around the globe—but notably, not the United States—have finally agreed on a treaty to improve how the world prevents, prepares for, and responds to future pandemics. scim.ag/4lDYcLe

Haha

Two positions in the @TrEE_Lab
Looking for students who are interested in genomic work & have basic training in handling genomic data. If you have a penchant for coding, writing scripts, & an interest in solving population genetic patterns in plants, apply! April 15th deadline.

#Immunology out now @science.org

After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.

buff.ly/49bKcTG

By Jobin, Seetharama, Rüttger et al.

The Systems Immunology Laboratory (SIL) keeps growing. Thank you Shreya Singh and Deepakshi Sahu - two new PhD students - for taking the group out for lab lunch. Sweet moments..

The Systems Immunology Laboratory (SIL) keeps growing. Thank you, Shreya Singh and Deepakshi Sahu - two new PhD students - for taking the group out for lab lunch. Sweet moments..

wow....

dogma indeed!!

wonderful read for today!

A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.

I wouldn't have anticipated a Lupus self-directed antibody (4H2) might someday turn out to be an anti-cancer treatment
www.science.org/doi/10.1126/...

So important article...

constant in variables!!!

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism Wang et al. reveal that DLAT, a pyruvate metabolism enzyme, modulates leucine metabolism by directly acetylating the leucine catabolism enzyme AUH at K109, leading to leucine accumulation and sustained mTOR activation in HCC. Restoring leucine catabolism…

Online now: Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

Tales from the cryptic pocket A synthetic cannabinoid biases CB1 signaling toward G proteins to elicit effective pain relief without tolerance in mice.

🧪In Science Signaling, I discuss work by Rangari et al. in Nature, showing that a synthetic cannabinoid stimulates biased signaling by CB1, promoting pain relief in mice without causing tolerance. The ligand binds through a linker to a cryptic site within CB1 to stimulate G protein coupling. #pain

This has only been possible through NIH funding.

Funding biomedical science through the NIH has been one of the greatest accomplishments of the United States of America for America, and for the world.

We are ALL better for the work that passionate scientists funded by the NIH have been able to do.

We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...

Please share!

now think of those in DELHI!!

Bluesky 1.99. Improvements: Videos are now up to 3 minutes long! A DMs "inbox" to approve or reject new direct messages. You can now mute accounts from a post's "..." menu. An improved moderation reporting flow. Better tablet-size layouts on Web. Better error reporting during signup.

📢 App Version 1.99 is rolling out now (1/5)

With every update, we’re aiming to make the Internet less toxic, more fun, and more in your control.

• 3 minute videos!
• A separate request inbox for DMs from unknown users
• Mute accounts more quickly

here it goes!!

1/ @nabroderick.bsky.social and @harmitmalik.bsky.social have posed questions asking how to US students may seek opportunities outside the US (EU and Canada). As a Department Chair in Canada in #immunosky, I offer my perspective in this "bluetorial".

A common cancer at an uncommon age The etiology of early-onset colorectal cancer needs to be understood to tackle rising incidence

Early-onset colorectal cancer is expected to become the leading cause of #cancer death in ages 20 to 49 in the U.S. by 2030.

Research is urgently needed to better detect and treat patients, argues this #SciencePerspective: scim.ag/4h1TYcQ #ColorectalCancerAwarenessMonth