Sean Flynn's Avatar

Sean Flynn

@seanflynn.bsky.social

Enhancers and 3D genome structure | Lecturer @uniofexeter.bsky.social | sites.google.com/view/flynnlab/

1,036 Followers  |  1,341 Following  |  8 Posts  |  Joined: 11.11.2024  |  1.744

Latest posts by seanflynn.bsky.social on Bluesky

Lots of exciting PhD projects available through @swbiodtp.bsky.social

If you are interested in our project using stem cells, CRISPR and genomics, please get in touch. Informal inquiries encouraged

Project:
www.swbio.ac.uk/files/2025/1...

06.11.2025 15:34 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Exciting postdoc opportunity!

21.10.2025 14:28 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below πŸ‘‡πŸ‘‡πŸ‘‡

www.imperial.ac.uk/jobs/search-...

18.09.2025 16:51 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

Check it out, Chromatin Kids!

Chromatin remodeller does stuff to Transcription Factors!

Functions where it is seldom seen!

Both decreases and increases chromatin accessibility!

How cool is that?

30.08.2025 16:18 β€” πŸ‘ 54    πŸ” 19    πŸ’¬ 3    πŸ“Œ 2
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders - GW4 BioMed MRC DTP Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Sum...

Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models

gw4biomed.ac.uk/architects-o...

gw4biomed.ac.uk/risk-vs-prot...

gw4biomed.ac.uk/rna-dependen...

gw4biomed.ac.uk/investigatin...

02.09.2025 12:22 β€” πŸ‘ 14    πŸ” 6    πŸ’¬ 1    πŸ“Œ 1
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Giant study finds a research field that’s mostly reproducible Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...

16.07.2025 17:55 β€” πŸ‘ 40    πŸ” 19    πŸ’¬ 2    πŸ“Œ 3
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DNA G-quadruplex structures act as functional elements in Ξ±- and Ξ²-globin enhancers - Genome Biology Background Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer–promoter interaction are incompletely understood. G-quadruplex...

How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?

In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...

04.06.2025 21:00 β€” πŸ‘ 15    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1

Happy to be part of this exciting work. A must-read for enhancer aficionados: A massive effort has gone into generating genome-wide STARRseq in hPSCs and conducting functional validation assays. Congratulations to all authors, Stefan and Ufuk, for leading this project πŸŽ‰.

03.06.2025 06:06 β€” πŸ‘ 27    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Please get in touch if you want to apply for this to work with me on chromatin remodellers, enhancers and lineage commitment in mammalian stem cells at @lsiexeter.bsky.social

08.05.2025 11:08 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! πŸ˜€

25.04.2025 07:29 β€” πŸ‘ 11    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

Job alert 🚨 We are hiring a research assistant!

This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.

Please spread the word!

17.04.2025 15:45 β€” πŸ‘ 15    πŸ” 16    πŸ’¬ 1    πŸ“Œ 1
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We have a postdoc position in my group in collaboration with EMBL Rome; join us to make important discoveries in this exciting project.
Please apply or share.

hrwebapp.qub.ac.uk/tlive_webrec...

31.03.2025 10:32 β€” πŸ‘ 8    πŸ” 11    πŸ’¬ 0    πŸ“Œ 3
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We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today!

Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!

allirelandchromatinconsortium.ie/annual-meeti...

24.03.2025 12:03 β€” πŸ‘ 15    πŸ” 13    πŸ’¬ 1    πŸ“Œ 3
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Award details | Funding and scholarships for students | University of Exeter

We have a funded PhD position available in Exeter @exeter.ac.uk
Gene Regulation in Brain Development and Disease 🧬
Please share / repost

www.exeter.ac.uk/study/fundin...

03.03.2025 10:57 β€” πŸ‘ 10    πŸ” 9    πŸ’¬ 0    πŸ“Œ 4
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jobs.exeter.ac.uk/hrpr_webrecr...
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!

16.12.2024 20:44 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1

Thread below on @robinburns.bsky.social et Al’s new paper #evobio #plantscience 🌱

11.12.2024 17:48 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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If you are interested in #Epigenetics apply for a PhD with Jack Hardwick and Jonathan Hanley in Bristol, and our group in Exeter.

Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...

22.11.2024 16:30 β€” πŸ‘ 7    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday!

We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below πŸ‘‡

19.11.2024 15:58 β€” πŸ‘ 28    πŸ” 10    πŸ’¬ 2    πŸ“Œ 3
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LSI PhD programme | Living Systems Institute | University of Exeter

Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social

"Control of chromatin remodeller activity to direct cell fate decisions"

#Chromatin #Transcription #StemCells #StructuralBiology

Please re-skeet!

www.exeter.ac.uk/research/ins...

07.11.2024 07:17 β€” πŸ‘ 12    πŸ” 24    πŸ’¬ 0    πŸ“Œ 1

Welcome @kherka.bsky.social, who is working on chromatin and G4s

14.11.2024 20:43 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Exciting!

11.11.2024 11:55 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@seanflynn is following 20 prominent accounts