stf-orm

Save travels and welcome to Europe.

This lesion here has the classic morphology of a traditional serrated adenoma and the typical BRAF-V600E-mutation. Note the non-neoplastic colonic crypts in the middle, which are negative for BRAF-V600E.

Pathology integrates the morphology of a lesion and its molecular alterations to come to definite diagnosis in the best case and to guide a patient's therapy, often in the oncological setting.

Shouldn't that be far more than enough for a soccer World cup in the USA? Under the current regime and the current conditions very few spectators from other, way more soccer-crazy countries will make it to the US, especially from latin America and Europe.

Congrats to our resident Michael Günther! He was awarded this year's G. Tiniakos award for best oral presentation at ESP congress Vienna.
Well deserved! 💪🏼 @i-med.ac.at @dinatiniakos.bsky.social

Estamos aquí para apoyar a pacientes y familias. 💜 Aprenda más ➡️ pancan.org/es

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THIS is one of the biggest problems of our time . . .

⬇️ ⬇️ ⬇️
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@i-med.ac.at @eurpancreaticclub.bsky.social Pancreas2000 meeting in Istanbul was a blast! Our resident Michael Günther presenting a Pancreas2000 project on sex differences in #PDAC treatment.

White House Announces Comprehensive Review of Smithsonian Exhibitions

You can't teach U.S. history without "divisive" narratives. Slavery wasn't "unifying." The Japanese incarceration wasn't "unifying." The anti-immigrant Operation Wetback (real name) wasn't "unifying."
It's history's job to tell the truth, not cover up past racism to pave the way for future racism.

Die Leute, die 800 Euro pro Stunde verdienen, haben die Leute, die 80 Euro pro Stunde verdienen, davon überzeugt, dass die Leute, die 13 Euro pro Stunde verdienen, das Problem sind.

Antibiotika könnten Leben von Patienten mit Bauchspeicheldrüsenkrebs verlängern – Deutsches Ärzteblatt

Jetzt auch in der deutschen Presselandschaft angekommen...
www.aerzteblatt.de/news/antibio...

Hier der Text des Aufrufs von ca 300 Rechtswissenschaftlerinnen und Rechtswissenschaftlern, darunter ehemalige Mitglieder des Bundesverfassungsgerichts. www.oer.ruhr-uni-bochum.de/oer/mam/cont...

Presseinformation 44/2025 - Medizinische Universität Innsbruck PatientInnen mit Bauchspeicheldrüsenkrebs überlebten doppelt so lang, wenn sie nach der operativen Krebsentfernung zusätzlich zur Chemotherapie mit Gemzitabin ein Antibiotikum erhielten. Das ist die zentrale Erkenntnis einer retrospektiven Studie von Steffen Ormanns, Leiter des Instituts für All...

🔝 PatientInnen mit Bauchspeicheldrüsenkrebs überlebten doppelt so lang, wenn sie nach der OP zur Chemotherapie mit Gemcitabin ein Antibiotikum erhielten. 👉 Wichtige Ergebnisse von @stf-orm.bsky.social​ und Team. Weitere Studien sind geplant.
#meduniibk

Dr O’Reilly on the Rapidly Evolving Role of Local Therapy in Metastatic Pancreatic Cancer Eileen M. O’Reilly, MD, discusses the rapidly evolving role of local therapy in the management of advanced/metastatic pancreatic cancer.

Dr O'Reilly on the Rapidly Evolving Role of Local Therapy in Metastatic Pancreatic Cancer - goo.gl/alerts/RfGamU #GoogleAlerts

"Die Hitzewelle zu verhindern wäre undemokratisch. Wir müssen die Dürre inhaltlich stellen ☝️😏"

Thank you for sharing our article! ❤️

I want to thank my whole team for their excellent work on these papers and our collaborators for their support! @i-med.ac.at

Intratumoral bacterial abundance confers poor response to adjuvant gemcitabine in resected pancreatic cancer patients which is mitigated by postoperative antibiotics - British Journal of Cancer British Journal of Cancer - Intratumoral bacterial abundance confers poor response to adjuvant gemcitabine in resected pancreatic cancer patients which is mitigated by postoperative antibiotics

in patients treated with adjuvant gemcitabine-based therapies. Even cases with high abundance+postopABT had a similar outcome as cases with low abundance and no ABT. Thus postoperative ABT shortly before adjuvant gemcitabine-based chemotherapy may serve as additive therapy. tinyurl.com/3htdnwdk

As one thinks about detrimental bacteria, one may instantly think about how to fight them, possibly by antibiotics (ABT). We determined how perioperative ABT affected patient outcome in the adjuvant situation. Surprisingly, only postoperative but not preoperative ABT improved the patients' prognosis

Thus we reasoned that it is not necessarily the bacterial composition but rather the bacterial abundance within a tumor which determines its response to gemcitabine as high abundances invariably come with high amounts of gemcitabine-degrading bacteria.

Finally, we sought to determine the role of gram-positive bacteria in this context as they may degrade gemcitabine, but with lower efficacy. Thus, we detected bacterial lipoteichoic acid (LTA), a surface marker of gram-positive bacteria in FFPE tumor samples and it resembled what we saw with LPS.

Bacterial Lipopolysaccharide as a Negative Predictor of Adjuvant Gemcitabine Efficacy in Pancreatic Cancer Abstract. Adjuvant gemcitabine (aGC) is one standard of care after pancreatic ductal adenocarcinoma (PDAC) resection. No biomarker for its efficacy is esta

This was the case for advanced PDAC tinyurl.com/yc6799rv but also for the adjuvant situation tinyurl.com/9sryx225.
By 16s rRNA sequencing on a subset of samples, we found that LPS positivity defined a specific intratumoral microbiome enriched for bacteria capable of gemcitabine degradation.

Indeed, not only did we find LPS in a good proportion of PDAC samples, we could also show that patients with LPS- positive tumors had a much worse outcome when treated with gemcitabine-based chemotherapy.

We then sought to determine whether 1. There were intratumoral bacteria in archival PDAC samples and 2. how they affected patient outcome. We focused on bacterial lipopolysaccharide (LPS), a marker of gram-negative bacteria detectable by immunohistochemistry(IHC).

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine In model systems, bacteria present in human pancreatic tumors confer resistance to the anticancer drug gemcitabine.

First, Geller et al. described the role of gram-negative bacteria within PDAC tumors tinyurl.com/487v65df
A finding which had previously been published, though a bit less prominent www.nature.com/articles/sre....

I would like to tell a little tale about our view on the microbiomes' implications in pancreatic cancer.
As pathologists, we mostly focus on the tumor tissue itself, not on non-neoplastic tissue afar from the tumor. Thus, we focus on the intratumoral microbiomes and its meaning for patient outcome.

Die Innpath der Tirol Kliniken / Allgemeine Pathologie der @i-med.ac.at ist auf der AustroDoc in Innsbruck vertreten! Komm vorbei und informier dich über die Möglichkeiten unseres Faches!
#pathology

🚨 From @ascocancer.bsky.social 2025

👉 Preop chemo with PAXG 🆚 mFOLFIRINOX for extending event-free survival (EFS) in resectable or BR PDAC (phase 3 CASSANDRA trial)

🆙 PAXG 3-year EFS 31% vs. 13% P = .003

🫸 Immature analysis for survival but.. future practice changing?! 🧐

@ascopost.bsky.social

Author conclusions #ASCO25

Die Pathologie der Tirol Kliniken und der Medizinischen Universität Innsbruck sind bei der AustroDoc am 3.6. in Innsbruck vertreten.
Komm vorbei und informier dich über die Perspektiven und Möglichkeiten unseres Faches!
@i-med.ac.at