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@jfabriciolh.bsky.social

Full-time father, part-time postdoc at Thornton Lab at UChicago | Evolutionary genetics

335 Followers  |  386 Following  |  27 Posts  |  Joined: 27.09.2023  |  2.3707

Latest posts by jfabriciolh.bsky.social on Bluesky

Yo tengo mi lista de esas canciones, siempre en reserva jaja.

04.10.2025 01:18 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Mi wife (an american) just taught me (a mexican) how to transform stale tortilla chips to fresh again using a mini oven. Nothing goes to waste in this house for sure.

26.09.2025 18:28 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes Background Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...

New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...

29.08.2025 14:05 โ€” ๐Ÿ‘ 162    ๐Ÿ” 76    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 5
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The nature of mutation: a legacy of bacterial genetics Abstract. A central question in the fields of genetics and evolution was the nature and origin of spontaneous mutation. Bacterial genetic experiments throu

I cannot fully put into words what publishing this Review has meant to me, so I leave you with how we closed the paper.

"The humble bacterium is still a relevant tool for the study of the underlying mechanisms that are conserved throughout life."

๐Ÿงช๐Ÿงซ๐Ÿงฌ๐Ÿ“š
doi.org/10.1093/gene...

25.08.2025 16:48 โ€” ๐Ÿ‘ 115    ๐Ÿ” 38    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1
116 FB 5 Research Assistant (m/f/d) field of Theoretical Ecology and Evolution or Computational Biology: Uni Osnabrรผck

Me and my group are searching for a senior postdoc (3 +3 years) in the field of theoretical/ computational biology.

The position provides the opportunity to closely interact with experimentalists and develop own research projects.

Please RT.

Deadline: 11/09/2025

Details ๐Ÿ‘‡:
shorturl.at/iiiOv

18.08.2025 05:35 โ€” ๐Ÿ‘ 4    ๐Ÿ” 8    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Protein language models reveal evolutionary constraints on synonymous codon choice Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: โ€œProtein language models reveal evolutionary constraints on synonymous codon choice.โ€ Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

07.08.2025 08:29 โ€” ๐Ÿ‘ 214    ๐Ÿ” 83    ๐Ÿ’ฌ 6    ๐Ÿ“Œ 4
Watercolor illustration of a crab

Watercolor illustration of a crab

Watercolor illustration of male and hermaphrodite rivulus fish

Watercolor illustration of male and hermaphrodite rivulus fish

Watercolor illustration of a sea otter in kelp

Watercolor illustration of a sea otter in kelp

Pen and colored pencil illustration of a green sea turtle

Pen and colored pencil illustration of a green sea turtle

I am opening scientific illustration commissions! Below are some examples of my work. Please contact me via bfitzwater@crimson.ua.edu if you are interested!

07.08.2025 16:32 โ€” ๐Ÿ‘ 86    ๐Ÿ” 35    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 3

Thank you. The art detail is incredible!

07.08.2025 17:15 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

How do you digitize them? The look fantastic

07.08.2025 17:06 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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๐Ÿšจ Attention early-career scientists! ๐Ÿšจ

Become a Theory Fellow at Janelia and use computation & theory to tackle biological problems.

โœ… Three-year appointment
โœ… Collaboration across scientific disciplines
โœ… Dynamic research environment

05.08.2025 14:49 โ€” ๐Ÿ‘ 12    ๐Ÿ” 7    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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M O I L A B - Join us! Join us! Our lab is based at the University of California, Berkeley, embedded in the vibrant and multicultural San Francisco Bay Area, surrounded by astonishing nature!

Network, we are looking for PhD students and Postdocs on evolutionary and ecological genomics in 2025/2026

Join our diverse and welcoming lab at UC Berkeley & HHMINEWS!

Check job ads-> www.moilab.science/team/join-us

22.07.2025 22:32 โ€” ๐Ÿ‘ 42    ๐Ÿ” 44    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
Text: Society for the Study of Evolution Graduate Research Excellence Grants. Rosemary Grant Advanced Awards, Deadline: September 15, 5:00 PM Eastern.

Text: Society for the Study of Evolution Graduate Research Excellence Grants. Rosemary Grant Advanced Awards, Deadline: September 15, 5:00 PM Eastern.

Applications now open for the SSE GREG Rosemary Grant Advanced Awards! These grants provide up to $3500 to expand your dissertation work. Submit your proposal by September 15!
www.evolutionsociety.org/content/soci...

15.07.2025 21:16 โ€” ๐Ÿ‘ 36    ๐Ÿ” 47    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Experimental evolution in an era of molecular manipulation - Nature Reviews Genetics In this Review, Ascensao and Desai discuss how methodological advances in genotype and phenotype manipulation are transforming experimental evolution approaches and providing new insights into the und...

Experimental evolution in an era of molecular manipulation
#ExperimentalEvolution #evolution #evoSky

www.nature.com/articles/s41...

21.07.2025 21:02 โ€” ๐Ÿ‘ 30    ๐Ÿ” 14    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Effective population size does not explain long-term variation in genome size and transposable element content in animals A large-scale survey across animals reveals no general association between genome size expansion and the relaxation of natural selection.

In @elife.bsky.social: Effective population size does not explain long-term variation in genome size and transposable element content in animals doi.org/10.7554/eLif...

19.07.2025 05:50 โ€” ๐Ÿ‘ 27    ๐Ÿ” 14    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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Functional regimes define soil microbiome response to environmental change - Nature Experimental perturbation of soil pH leads to a generalizable model of the soil microcosm comprising three functional regimes with distinct mechanisms linking environmental change to metabolite dynami...

Published in Nature today! Here, we sought to systematically ask how natural community's metabolism changes with the environment. A simple consumer-resource model can predict N-cycle metabolism (nitrate use) and, more importantly, the mechanism behind its change.
www.nature.com/articles/s41...

16.07.2025 15:19 โ€” ๐Ÿ‘ 68    ๐Ÿ” 30    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 4
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Sloan Lab Welcome! Our research focuses on the evolutionary process at the molecular level. In particular, we investigate how a mixture of natural selection and non-adaptive forces create and maintain the amazi...

Please share! Our lab is recruiting a PhD student to join us starting fall 2026. Our group is broadly interested in plant molecular evolution and comparative genomics. More info about our lab and grad programs at Colorado St. is available on our lab website.

sites.google.com/site/danielb...

14.07.2025 19:35 โ€” ๐Ÿ‘ 45    ๐Ÿ” 51    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

We all are Pedro Pรกramo's kids, except my brother I guess.

11.07.2025 18:21 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Agreed, also one can be surprised when a good sentence is written.

08.07.2025 16:56 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I'm recruiting a 2-yr postdoc to start in October or November of 2025! I'm looking for applicants interested in exploring amphibian disease ecology as it relates to climate change. Strong quantitative skills preferred, interviews start late July. More info: erinsauer.com

07.07.2025 18:55 โ€” ๐Ÿ‘ 28    ๐Ÿ” 30    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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Yeast Call for Papers: Yeast in Microbiomes Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

The deadline for submissions to the special issue "Yeast in Microbiomes" has been extended to 15 October. We accept manuscripts exploring yeast diversity, interactions, and adaptations in diverse host environments. Hurry up and don't miss this opportunity!!!

onlinelibrary.wiley.com/page/journal...

07.07.2025 16:16 โ€” ๐Ÿ‘ 3    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Functional amyloid proteins confer defence against predatory bacteria Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...

Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.

02.07.2025 20:10 โ€” ๐Ÿ‘ 164    ๐Ÿ” 52    ๐Ÿ’ฌ 6    ๐Ÿ“Œ 4

Congratulations, Alison! This is awesome.

27.06.2025 16:22 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Race, ethnicity donโ€™t match genetic ancestry, according to a large U.S. study Data from the All of Us program confirm what many geneticists have long promoted

www.science.org/content/arti...

05.06.2025 21:26 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Now published in PNAS: www.pnas.org/doi/10.1073/...

23.05.2025 18:39 โ€” ๐Ÿ‘ 99    ๐Ÿ” 40    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Schematic of TN-seq in C. neoformans. Top left: Transposon insertions (orange arrow) into nonessential genes results in viable cells. In contrast, insertions into essential genes will result in dead and nonrecoverable cells. Top right: TN-seq works by generating a library of cells where each cell has a single independent transposon insertion in a random location. As in A, those insertions into essential regions cause the cells to die and are nonrecoverable. As a result, the total library (bottom) is depleted in insertions in essential regions. Bottom: The Ac/Ds transposon was split into an Ac transposase and a Ds transposon containing a neomycin resistance marker. This Ds transposon was integrated into an intron of URA5 and the Ac transposase was integrated into the safe haven locus. The resulting stain is uraโˆ’ and neomycin resistant. Upon initiating transposition via growth on galactose, the strain becomes URA+ and mutant at another locus (depicted here as YFG1).

Schematic of TN-seq in C. neoformans. Top left: Transposon insertions (orange arrow) into nonessential genes results in viable cells. In contrast, insertions into essential genes will result in dead and nonrecoverable cells. Top right: TN-seq works by generating a library of cells where each cell has a single independent transposon insertion in a random location. As in A, those insertions into essential regions cause the cells to die and are nonrecoverable. As a result, the total library (bottom) is depleted in insertions in essential regions. Bottom: The Ac/Ds transposon was split into an Ac transposase and a Ds transposon containing a neomycin resistance marker. This Ds transposon was integrated into an intron of URA5 and the Ac transposase was integrated into the safe haven locus. The resulting stain is uraโˆ’ and neomycin resistant. Upon initiating transposition via growth on galactose, the strain becomes URA+ and mutant at another locus (depicted here as YFG1).

#Fungal infections are hard to treat due to #DrugResistance. @blakebillmyre.bsky.social &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @plosbiology.org ๐Ÿงช plos.io/4dz3iVm

24.05.2025 09:44 โ€” ๐Ÿ‘ 18    ๐Ÿ” 5    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Text: Virtual Evolution 2025. Society for the Study of Evolution Hamilton Award Symposium. Thursday, May 29, 1:30 PM - 7:30 PM Eastern (GMT-4). 2025 Finalists: Meaghan Clark, Dylan DeBaun, Devon DeRaad, Simon Innes, Josh Knecht, Kip Lacy, Gina Lamka, Prothama Manna, Gemma Martinez-Redondo, David Peede, Gabriel Preising, Jeremy Summers, David Tian, Matthew Treaster, and Amanda Vieira da Silva.

Text: Virtual Evolution 2025. Society for the Study of Evolution Hamilton Award Symposium. Thursday, May 29, 1:30 PM - 7:30 PM Eastern (GMT-4). 2025 Finalists: Meaghan Clark, Dylan DeBaun, Devon DeRaad, Simon Innes, Josh Knecht, Kip Lacy, Gina Lamka, Prothama Manna, Gemma Martinez-Redondo, David Peede, Gabriel Preising, Jeremy Summers, David Tian, Matthew Treaster, and Amanda Vieira da Silva.

Congratulations to this year's Hamilton Award finalists! ๐ŸŽ‰ Join us Thursday, May 29 to hear these outstanding student talks. See the full schedule on the meeting website: www.evolutionmeetings.org/program-over... @evolmtg.bsky.social

22.05.2025 07:22 โ€” ๐Ÿ‘ 40    ๐Ÿ” 21    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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10/n To relax this assumption, we take advantage of the progress in geometric deep learning. More specifically, we use a neural network called a "Riemannian Hamiltonian Variational Autoencoder" (RHVAE) that not only reduces dimensionality but preserves the geometric relationships between data points

15.05.2025 14:33 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

1/n ๐Ÿงต Excited to share our new paper! We developed a framework to reveal hidden simplicity in how organisms adapt to different environments, particularly focusing on antibiotic resistance evolution. #EvolutionaryBiology #MachineLearning

15.05.2025 14:33 โ€” ๐Ÿ‘ 38    ๐Ÿ” 22    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

I would definitely appreciate doing only one injection.

11.05.2025 04:25 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!

25.04.2025 23:46 โ€” ๐Ÿ‘ 51    ๐Ÿ” 34    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@jfabriciolh is following 20 prominent accounts