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Craig Kaplan

@triggerloop.bsky.social

Professor, Department of Biological Sciences, University of Pittsburgh. RNA polymerase II mechanism, classic films, #classiccountdown once in awhile

3,591 Followers  |  724 Following  |  5,626 Posts  |  Joined: 12.06.2023  |  2.2173

Latest posts by triggerloop.bsky.social on Bluesky

I don’t remember Laramie like this

11.12.2025 20:25 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Can this also be a shower

11.12.2025 20:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Really important that this is out for those waiting for it

11.12.2025 19:50 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

And the fact that he still looks better than Kent who just got in :(

11.12.2025 17:36 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Same Product, Same Store, but on Instacart, Prices Might Differ

Instacart got caught running real-time price experiments on shoppers β€” same groceries, different prices.

Workers know this game well: Instacart’s algorithm does the same thing to their pay.
www.nytimes.com/2025/12/09/b...

10.12.2025 23:35 β€” πŸ‘ 1217    πŸ” 619    πŸ’¬ 56    πŸ“Œ 54

Already posted it (but still need to read haha)

11.12.2025 14:11 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Structure of cytoplasmic RNA polymerase II

www.biorxiv.org/content/10.6...

11.12.2025 08:16 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

That’s the stuff

11.12.2025 02:27 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Completely on brand for that guy- but almost takes the cake still

11.12.2025 00:47 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

SET1/MLL complexes control transcription independently of H3K4me3 https://www.biorxiv.org/content/10.64898/2025.12.08.692985v1

11.12.2025 00:32 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

My current experience is that if a single word about investigator is said it is nipped in the bud. The savvy reviewers will talk about development of crucial systems or reagents that empower the proposal or creativity of approaches over time that have allowed PI to…

11.12.2025 00:32 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I wish the headline didn’t have the β€œdo” and the question mark. Because we know they are safe.

11.12.2025 00:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

While it’s hard for reviewers not to contaminate their review with past practices, they are not allowed to use those types of words to make the case for their score. So that easy thumb on scale I think is out. They have to use other words to do it- so potentially need to be more compelling

11.12.2025 00:23 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Oh no

11.12.2025 00:13 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

It’s uncanny

10.12.2025 22:16 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I just have feeling that they came in by virus!

10.12.2025 05:36 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

This guy is so shameless

10.12.2025 04:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

He was doing these lines before like everybody has too much stuff - I can’t believe people are still showing up to these things. Maybe it’s a measles party

10.12.2025 03:51 β€” πŸ‘ 16    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Yeah I wasn’t in the same dimension

10.12.2025 02:25 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Man surround by people holding a microphone and saying WOULD

Man surround by people holding a microphone and saying WOULD

10.12.2025 02:20 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Wow!

10.12.2025 01:56 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

It's like they are actively trying to kill the tourist industry.

10.12.2025 01:46 β€” πŸ‘ 3568    πŸ” 976    πŸ’¬ 205    πŸ“Œ 71

They are sentient FreeRepublic comments at this point

10.12.2025 01:46 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

mgo might need to start β€œhere is where I predict 2X what Kenpom predicts”

10.12.2025 01:43 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Frictionless brain on Rubes

10.12.2025 01:42 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I was thinking closer to your number also

10.12.2025 00:22 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Report: COVID-19 vaccines saved US $1.15 trillion, 3 million lives COVID-19 vaccines prevented more than 18.5 million US hospitalizations and 3.2 million deaths, according to new estimates.

There are a few more - sorry I got sidetracked thinking about the wreck of the NIH and my career www.cidrap.umn.edu/covid-19/rep...

09.12.2025 23:50 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Lives and life-Years Saved From COVID-19 Vaccination This comparative effectiveness study analyses the number of lives and life-years saved worldwide among those who had been vaccinated during the COVID-19 pandemic 2020-2024 years.

jamanetwork.com/journals/jam...

09.12.2025 23:12 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...

Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...

09.12.2025 22:13 β€” πŸ‘ 24    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0

Look. At. This. Crazy. Thing!!!

09.12.2025 21:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

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