Ryan McCool | PhD Candidate's Avatar

Ryan McCool | PhD Candidate

@rmccool.bsky.social

Structural Biologist and Protein Engineer in the McLellan Lab at UT Austin. Fitness Fanatic and wannabe Polyglot at home.

58 Followers  |  128 Following  |  1 Posts  |  Joined: 11.11.2024  |  1.2298

Latest posts by rmccool.bsky.social on Bluesky

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A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain HCoV-229E is an endemic Alphacoronavirus that typically causes common cold-like disease in most healthy adults, but can also cause severe respiratory disease in the very young and the elderly. Althoug...

Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC.

www.biorxiv.org/content/10.1...

19.05.2025 10:34 β€” πŸ‘ 17    πŸ” 11    πŸ’¬ 1    πŸ“Œ 2
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Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social‬, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...

20.05.2025 18:19 β€” πŸ‘ 53    πŸ” 20    πŸ’¬ 1    πŸ“Œ 1

I’m super excited to see this work out from my lab/PhD-cohort-mate @elizabeth-mcfadden.bsky.social. By engineering and structurally analyzing a soluble gp38-Gn-Gc complex, she develops new insights for CCHFV and other type II viral fusion proteins alike. Definitely worth the read!

21.12.2024 19:13 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

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