Xavier Corominas-Teruel

A human brain network linked to restoration of consciousness after deep brain stimulation - Nature Communications In people with severe brain injuries, stimulation restored consciousness by engaging a deep brain circuit for wakefulness—revealing a target that may also guide treatment in stroke and epilepsy.

Just dropped in @natcomms.nature.com: we show that re-engaging a thalamic–ventral tegmental circuit with deep brain stimulation can reignite consciousness in patients with severe brain injury. Work led by Aaron Warren, with @andreashorn.org @foxmdphd.bsky.social @ others! tinyurl.com/4kz8j89b

Brani’s Stimupedia

TMS at 40 Celebrating 40 Years of Innovation and Advancing Frontiers in Transcranial Magnetic Stimulation

🎉 40 Years of TMS: Registrations are now open!

We will be joined by experts in the field to reflect on four decades of progress and explore how TMS continues to push the boundaries of neuroscience, neuromodulation, and clinical practice.

➡️ Register Now: www.eventbrite.co.uk/e/tms-at-40-...

/1 We took our sweet time (~3yrs) to put this into its final shape - but happy to say that the pre-print of an extensive review of brain rhythms in cognition - from a cognruro perspective - is now available. Please let us know what you think. #neuroskyence doi.org/10.48550/arX...

Top left: Raster plot showing the neural spiking of different types of neurons across layers. The red dots represent excitatory neurons, while the others represent parvalbumin-positive interneurons (blue), somatostatin-positive interneurons (green), and 5-HT3a receptor-positive interneurons (purple), respectively. Top right: Averaged firing rate of excitatory neurons across layers over time, calculated using a 2 ms time bin. Dash lines indicate the onset of flash stimuli. Bottom: Schematic illustration explaining the phase dependency. The synaptic input from the lateral geniculate nucleus (LGN) enters the region adjacent to basal dendrites in deeper layers (gray circle), which are highly responsive to this input (left). When the peak phase of AC flows in a downward direction (middle), the membrane potential in basal dendrites is depolarized, leading to a weaker driving force. It results in weaker (less negative) excitatory postsynaptic current (EPSC) affecting change in LFPs and vice versa during the trough phase.

Electrical #BrainStimulation can be used to modulate #brain activity but how does it affect the #CorticalLayers? This study shows that only the deeper layers show phase-dependent changes in local field potential components upon electrical stimulation @plosbiology.org 🧪 plos.io/406W3i5

Frontiers | Modulating excitation/inhibition balance through transcranial electrical stimulation: physiological mechanisms in animal models The balance between excitatory and inhibitory (E/I) activity is a fundamental property of neural circuits, ensuring precise information processing and preven...

📢 Just published in Frontiers in Neuroscience!
🧠⚡ Modulating excitation/inhibition balance through transcranial electrical stimulation: physiological mechanisms in animal models

Improving Cerebellar TMS Targeting: MRI-Neuronavigation and Landmark-Based Approaches Assessed by E-Field Modeling Transcranial magnetic stimulation (TMS) is widely employed to modulate cerebellar activity [1]. Although neuronavigation is widely used to target cortical regions, cerebellar TMS is still predominantl...

Vridhi Rohira & colleagues propose combining magnetic resonance imaging (MRI)-based neuronavigation on a cerebellar spatially unbiased atlas template SUIT atlas to improve cerebellar TMS targeting.

www.brainstimjrnl.com/article/S193...

Maximilian Lueckel, Suhas Vijayakumar, Til Ole Bergmann: PlanTUS: A heuristic tool for prospective planning of transcranial ultrasound transducer placements https://arxiv.org/abs/2506.22563 https://arxiv.org/pdf/2506.22563 https://arxiv.org/html/2506.22563

🚨 New paper alert from Weise et al.!

"A leadfield-free optimization framework for transcranially applied electric currents"

🔋 Optimize TES, TIS, ECT & TTFields without fixed leadfields
🧠 Electrode placement adapts to individual anatomy
💻 Now available in SimNIBS!

doi.org/10.1016/j.co...

Low frequency oscillations – neural correlates of stability and flexibility in cognition - Nature Communications How the brain balances the flexibility and stability needed to both encode and maintain information during cognition remains poorly understood. Using MEG data and in-silico simulations, the authors sh...

Low frequency oscillations – neural correlates of stability and flexibility in cognition
www.nature.com/articles/s41...
#neuroscience

Benchmarking methods for mapping functional connectivity in the brain | doi.org/10.1038/s415...

What is the best measure of functional connectivity (FC)?

led by @zhenqi.bsky.social in @natmethods.nature.com ⤵️

Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation Transcranial ultrasonic stimulation (TUS) redefines what is possible with non-invasive neuromodulation by offering unparalleled spatial precision and flexible targeting capabilities. However, peripher...

Hold on to your transducers, TUS community! We've focused on managing what participants can hear during stimulation… but how about what they feel?! Our BrainStim paper maps tactile, thermal, & painful sensations during transcranial ultrasonic stimulation - and reveals how to minimize them. Thread👇

The June 2025 cover of the Journal of Neurosurgery. The cover illustration depicts the clinical applications of high-frequency and low-frequency focused ultrasound (FUS) in the management of glioma. Art by Ken Probst.

On the cover of the Journal of Neurosurgery, Jacob Young, MD & Manish Aghi, MD, PhD, review the role of focused ultrasound (FUS) in treating gliomas, highlighting how low-frequency FUS can disrupt the blood-brain barrier to enhance drug delivery: thejns.org/view/journal... @ucsfcancer.bsky.social

Noninvasive reduction of neural rigidity alters autistic behaviors in humans - Nature Neuroscience Autism is associated with inflexibility of brain dynamics. Watanabe and Yamasue show that TMS over the right superior parietal lobule while the brain is ‘stuck’ in a certain state reduces this rigidit...

Autism is associated with inflexibility of brain dynamics. Watanabe and Yamasue show that TMS over the right superior parietal lobule while the brain is ‘stuck’ in a certain state reduces this rigidity and relieves various autistic traits.

@takamitsuw.bsky.social

www.nature.com/articles/s41...

Oscillatory impact of Transcranial Magnetic Stimulation at very weak-intensity on the primary motor cortex: A TMS-EEG study in the human brain https://www.biorxiv.org/content/10.1101/2025.02.04.636500v1

EPICURUS: E-field-based spatial filtering procedure for an accurate estimation of local EEG activity evoked by Transcranial Magnetic Stimulation https://www.biorxiv.org/content/10.1101/2025.02.16.638512v1

Want to optimize cerebellar TMS?
Our latest paper by @VridhiRohira & @CorominasXavier shows how to improve targeting precision. Don’t miss it! 👇

(PDF) Real-world effectiveness of a single-day regimen for transcranial magnetic stimulation using Optimized, Neuroplastogen-Enhanced techniques in Depression (ONE-D) PDF | Background: Conventional transcranial magnetic stimulation (TMS) regimens are logistically burdensome, requiring days or weeks of clinic visits.... | Find, read and cite all the research you nee...

New landmark TMS trial dropped by Jonathan Downar's team, which will revolutionize care for depression even more than the SAINT trial did – extensive (10 hour!) sessions of TMS in a single day, enhanced by single dose of cycloserine. 90% response, 70% remission!

www.researchgate.net/publication/...