a cartoon of patrick and spongebob with the words team work below them ALT: a cartoon of patrick and spongebob with the words team work below them

11/11 Sincere thanks to our editors and reviewers at @naturecomms.bsky.social, and to all our collaborators at @camhnews.bsky.social, @stanfordbrain.bsky.social, @stanfordpntlab.bsky.social, @stanfordmedicine.bsky.social and @Università Milano who made this work possible!

10/11 These findings have exciting implications for brain stimulation therapies in psychiatry and neurology. Targeting high-order vs low-order networks might require completely different stimulation approaches!

lebron james is wearing a yellow lakers jersey with the number 23 ALT: lebron james is wearing a yellow lakers jersey with the number 23

9/11 As
@DanteSommoPoeta
wrote: "The more perfect a thing is, the more it feels." In the brain, like basketball, star players like
@Lebron James
(cognitive networks) react dramatically to game changes while role players (sensory networks) maintain steadier, independent performance.

8/11 Meanwhile, low-order sensory networks were barely affected by removing these feedback connections! Their responses remained strong, suggesting they rely mostly on local processing rather than whole-brain feedback.

7/11 The results were striking: high-order networks NEED feedback from the rest of the brain to generate their full response. When we cut these feedback connections, their responses were significantly reduced.

6/11 But why? To understand the mechanism, we built computational models of each patient's brain based on their anatomical connections, and then performed "virtual dissections" - selectively removing connections between networks.

5/11 We discovered an "excitability gradient" across the brain! High-order cognitive networks (like the Default Mode Network) showed much stronger responses to stimulation than low-order sensory networks.

TMS-evoked responses are driven by recurrent large-scale network dynamics Whole-brain computational modelling, incorporating novel ML-based parameter estimation techniques, reveals how transcranial magnetic stimulation-evoked brain responses are driven at earlier timepoints...

4/11 Based on our previous computational modeling work (elifesciences.org/articles/83232), we used rare data from 36 epilepsy patients, recording brain activity during 323 electrical stimulation sessions. This gave us a unique window into how stimulation activates different brain regions!

3/11 Building on
@Daniel S. Margulies' seminal work on the "principal gradient" of brain organization (pnas.org/doi/10.1073/...), we asked how these different networks respond to direct electrical stimulation.

From sensation to cognition. Abstract. Sensory information undergoes extensive associative elaboration and attentional modulation as it becomes incorporated into the texture of cogniti

2/11 The human brain has a fascinating organization: from simple sensory regions to complex cognitive networks. We wondered: do these different networks respond differently when stimulated? And does this follow the brain's known hierarchical organization?

academic.oup.com/brain/articl...

1/11 How does our brain's hierarchical organization impact its response to stimulation? We found striking differences between "high-order" networks (involved in complex cognition) vs "low-order" networks (handling sensory/motor functions)
@naturecomms.bsky.social

www.nature.com/articles/s41...

My school in Tanzania is running well! The Giona Basketball Academy just hosted a U12–U19 tournament last week—so much fun! Want to join me in Tanzania, explore the country, and make an impact at my school? DM me! #FreeEducation #SportsValue #Basketball #Tanzania

🚀 @GiovanniRabuffo is presenting our poster "Large-Scale Neural Dynamics as a Predictor of Stimulus Effects" at the 6th #BrainStimConf!

📍 Poster P2.064

Don't miss it—come discuss our latest findings on neural dynamics and stimulation effects! #BrainStimulation #Neuroscience

Excited to attend Brain Stimulation Conference! Presenting 3 talks and chairing the symposium on Computational and Mathematical Models of Brain Stimulation-Induced Synaptic Plasticity. Looking forward to great discussions and connecting with this amazing community! #BrainStimConf

Truly honored and grateful that our symposium Advancements in Brain Stimulation Modeling has been accepted for #OHBM2025 marking our third time being part of this incredible event. Heartfelt thanks to the @ohbmofficial.bsky.social community for this opportunity! #BrainStimulation #modelling

🎉 Thrilled to announce that our course on Neural Field Theory & Brain Networks has been accepted for #OHBM2025! Third year teaching computational neuroscience at OHBM. Can't wait to explore brain dynamics in Brisbane!

@ohbmtrainees.bsky.social
@drbreaky.bsky.social @johndgriffiths.bsky.social