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Josie Gleeson

@josiegleeson.bsky.social

Postdoc in the Lappalainen lab at @scilifelab.se RNA fangirl πŸ‘©πŸΌβ€πŸ’»

40 Followers  |  80 Following  |  6 Posts  |  Joined: 27.11.2024  |  1.6275

Latest posts by josiegleeson.bsky.social on Bluesky

Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center Find a career with New York Genome Center

We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...

08.10.2025 14:41 β€” πŸ‘ 10    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1

Congratulations Ric and @michaelbclark.bsky.social!

03.10.2025 07:53 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Great work Yupei!

16.09.2025 08:53 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Very excited to see our latest paper published!

12.08.2025 09:52 β€” πŸ‘ 11    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

No prob! Definitely doable, dRNA will be less biased than cDNA but may not get you the best depth. We had a post-mortem brain sample at RIN 7.8 and it still looked ok. I'd just advise using the RIN as a cofactor in analysis if you have varied samples.

04.06.2025 11:17 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Pervasive effects of RNA degradation on Nanopore direct RNA sequencing Abstract. Oxford Nanopore direct RNA sequencing (DRS) is capable of sequencing complete RNA molecules and accurately measuring gene and isoform expression.

You can check out our paper here but we only went to a minimum of 7: doi.org/10.1093/narg.... Probably wouldn't advise doing it with much lower... depends what you want to see!

04.06.2025 10:22 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...

New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...

05.05.2025 15:39 β€” πŸ‘ 74    πŸ” 28    πŸ’¬ 4    πŸ“Œ 0

Weird, for some reason I always thought amino acids would be way bigger!

21.03.2025 13:50 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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