SusanK

theres a long road between this and a treatment in humans but this is a cool development

New Thoeris systems and new bacterial TIRs, this time also producing plant and human immune signals 2'cADPR and cADPR!!! Congratulations to @erezyirmiya.bsky.social and Azita Leavitt! It was a pleasure to be involved in this project.

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...

The result of a fantastic Iwasa-Drubin lab collaboration.

@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...

PeeWee Herman vibe

This entire thread makes me want to bawl. Inspiring, courageous, defiant.

Also, we all deserve #freemomhugs

worked for Kavanaugh

Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain Structure-based drug design has traditionally focused on optimizing static, enthalpic interactions between ligands and proteins or on displacing binding site solvent molecules to entropically favor bi...

New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them?

www.biorxiv.org/content/10.1...

"Oh, honey. I am one of the people that AI tries to sound like"

Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency https://www.biorxiv.org/content/10.1101/2025.11.26.690573v1

There should be a sniglet for tfw you have to give up making fun of something because the thing actually worked for you too

It’s time for our one sale of the year! Take 20% off with code holiday20 (ends 12/2/2025). The sale includes all of our puzzles and most of our jewelry n-e-r-v-o-u-s.com/shop

Starbucks workers' union escalates strike on Black Friday () -The Starbucks workers' union said on Friday it is escalating an indefinite strike to more than 120 stores and 85 cities, ​demanding higher pay and staffing levels at the coffee chain. The walkout,...

Starbucks employees escalated their strike on Black Friday, expanding to 120 stores and 85 cities.

Their CEO took home $96 million while refusing to negotiate a living wage for workers.

Boycott Starbucks. Stand with the employees.

Support local independent coffee shops:

Disabled people deserve healthcare.

Disabled people deserve housing.

Disabled people deserve food.

Disabled people deserve support.

Our ability to work and produce for capitalism should not determine our value.

Disability is not a moral failing. Most people will experience it someday.

Understandable! My daughter reminded me she can be age 24 but have only as much experience presenting female as a typical 14-yr-old. She deserves all the grace & patience we would give a young girl as she navigates self-care & how she wants to look. You do too!

Mini-agrin prevents calcium leakage and restores the dystrophin complex. https://www.biorxiv.org/content/10.1101/2025.11.25.690165v1

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...

50% off ebooks the world SALE kinda half-assed and barely visible use code UGHFINE

📚 50% off ebooks because capitalism i guess
use code UGHFINE
or you could just buy them! up to you 📚

www.neonhemlock.com/ebooks

The mechanism of Lamassu, an abundant bacterial immune system, is now solved

Lamassu evolved from a DNA repair complex

Beautiful study from the Patel, Bernheim and Sternberg labs

A *huge* vaccine victory. I've been writing on this for years; Australia has seen remarkable progress in cervical cancer prevention with the HPV vaccine. I love seeing science triumph like this.

PSA

It's ok to feed your autistic kid nuggets today.

It's ok to let your kid be alone in their room while the rest of the family is having dinner.

It's ok to let them be autistic without judgment.

They get enough of that from the rest of the world. ❤️

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Very happy to have been able to contribute to this study that was published today in Science, which was truly a great collaborative effort. Avian PB1 provides a fitness advantage to IAV at febrile-range temperatures both in vitro and a hyperthermic nouse model 🦠 www.science.org/doi/10.1126/...
#flu

Today and every day I am thankful for people who love doing science and people who love sharing science!

"This future cannot come fast enough,” says Seattle Hub's Jesse Gray.

"We are realizing a revolution in programming biology that has incredible potential."

https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record

Just uploaded our new preprint to @ecoevorxiv.bsky.social

Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀

We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...

I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social

With the goal of reaching new ppl w/biodiversity action, we're expanding the Native Plant Project to bars. We're calling it Biodiversity Beers.

In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱

Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.

A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.

Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.

www.science.org/doi/10.1126/...

Oh my gosh. This is... A thing. Please allow a microbiologist who has played with the microbe that makes this to waffle on for a bit in a short thread. (1)