bishara marzook

Thanks Ana!

Thanks Steph!! Yes loads more work to be done

Yes the publishing process was an insightful journey indeed! Grateful to the editors and reviewers for valuing this dataset and outcomes :)

My background is in molecular microbiology and parasitology, with a focus on malaria drug resistance. I’ve worked across international collaborations, mentored, and published in high-impact journals. Open to research, project-management, or education-focused roles in academia, govt or industry.

I’ve recently been made redundant from my role at UNSW due to the NIH’s decision to cancel foreign subawards. It’s an unfortunate situation affecting a lot of great researchers, and I’m now on the lookout for something new. If anyone knows of any molecular biologist roles coming up, let me know!

We are so excited to see the new avenues for research this will create! 👏👏👏 @ghostpathogen.bsky.social @lottabaumgaertel.bsky.social @netanyabernitz.bsky.social @tapokam.bsky.social @lucy-watson.bsky.social @crick.ac.uk

Thank you so much!

Oh, and a big thank you to our reviewers! The paper really benefited from them pushing us to explore and contextualise the data more deeply, so we thank them for their contributions and acknowledge their labour for the science we all love.

In these taxing times, I can only say that I count myself extremely fortunate to get to do what I love with people who make it worthwhile. I would not be here if not for them. I hope I can continue to do so and bring more people along on this continuing Crypto voyage.

Thankful to everyone in @saterialelab.bsky.social for making this journey so enjoyable, especially to Adam for giving me a shot on this huge project and guiding it through to the end. And of course the High-Throughput Screening team @crick.ac.uk for their invaluable expertise

We used this large dataset this created to discover some interesting host cell biology, unexpected Crypto biology, and even potentially a new host-directed treatment for this deadly disease. You can read the full thread about our findings here: bsky.app/profile/ghos...
#MicroSky

We asked what happens if you disable almost every protein-coding human gene by CRISPR-Cas9 one by one in epithelial cells, infect those cells with the intestinal parasite #Cryptosporidium, and observe the resulting infection phenotypes by high-content microscopy to map the parasite's dependencies.

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

Research Technician at UCL Apply now for the Research Technician role on jobs.ac.uk - the leading job board for higher education jobs. View details.

Last chance to apply for great research tech #job in my friendly lab @uclmedsci.bsky.social in London! Cutting-edge organoid and microbiology work seeking to understand how probiotic bacteria might be deployed to fight urinary infection #UTI. Closes 23 July #UTISky www.jobs.ac.uk/job/DNQ902/r...

For those interested in Masters in lab and field based research in infectious disease we have 3 fantastic programmes to choose from MSc Immunology, medical parasitology and entomology and medical microbiology. They benefit from very flexible module choices and summer projects in UK and abroad!

Open call: If you are a researcher working on a project estimating a cause-specific burden of disease attributable to climate change at regional to global scales, please reach out! We're looking for researchers who might be interested in joining a new collaborative network / workshop series.

Pre-print alert 🚨: We have developed 2D and 3D stable iPSC endothelial-differentiation models through dox inducible ETS expression. We demonstrate endothelial identity and used these models for studying malaria pathogenesis research. www.biorxiv.org/content/10.1...

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...

I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...

Postdoc position open to investigate chronic Toxoplasma infection!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Very cool work! More proof we have a lot to learn about actin and associated nucleation factors from apicomplexans :)

Woody Guthrie's guitar... hello

Honoured to have been invited to give a hallowed GRiP-ing seminar yesterday in Glasgow! Thanks @abhinay.bsky.social for the invite and @uofgsii.bsky.social for hosting me! Now enjoying the classic Glaswegian weather 😁 (yesterday was beautiful though!)

Omaya Dudin Interview with Omaya Dudin, who uses Ichthyosporea as models to study how and why unicellular organisms evolved multicellularity at the University of Geneva.

90% of you probably don’t need to read this.
But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy.
It’s about sharing something hard to say out loud;
partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO

Identifying antimalarials that disrupt malaria parasite transmission when fed to the mosquito A decade-long decline in malaria cases has plateaued, primarily due to parasite drug resistance and mosquito resistance to insecticides used in bed ne…

We are developing a simple, very cheap, low tech way to reduce malaria transmission. Instead of giving the antimalarials to people, we give them to the mosquitoes that spread the parasite. How do we drug a mosquito? Read on. www.sciencedirect.com/science/arti...

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Had a great time at this, learned so much! Thank you again for having a parasitologist amongst you. Looking forward to more host-pathogen interaction interactions 😁

Make open access to tools and data part of your annual giving by making a tax deductible donation to @veupathdb.org. 💙This resource simplifies and supercharges global infectious disease research.

Need more reasons to support VEuPathDB? Here's a short list: veupathdb.org/veupathdb/ap...

"Journal club" aka science hermeneutics

Need help with bioimage analysis? Contact the UK Euro-BioImaging Node to see how we can help!

www.eurobioimaging-access.eu/nodes/uk-node

Text reads "Congratulations to the 2025 Leading Edge Fellows" followed by the Leading Edge logo and www.leadingedgesymposium.org. Below are the headshots and names of the 40 new Leading Edge Fellows. They are Cel Welch Lianna Wat Maria Toro Moreno Sarah Talley Xulu Sun Ines Sturmlechner Virginia Savy Amelie Raz Kali Pruss Caterina Profaci Sarah Pierce Melissa Pamula Kehinde Odufowora Patricia Nano Ariana Musa de Aquino Nour El Houda Mimouni Kathleen Martin Brea Manuel Mable Lam Miri Krupkin Elaine Kouame Megan Kirchgessner Sumin Kim Shubhangini Kataruka Geraldine Jowett Andrea Jones Leanne Iannucci Emily Heckman Allison Girasole Florencia Fernandez Chiappe Tonie Farris Hannah Elam Erin Doherty Xiaoyun Ding Maria Bustillo Julia Brunner Debadrita Bhattacharya Lorena Benedetti Ashley Anderson Krisha Aghi

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows