Khaled_Selim Lab

Alcohol dehydrogenases are know to form high-order aggregates of spirosomes, making them hard to express....

See below 👇 a solution of pH-modulated soluble expression with adaptive evolution

www.cell.com/trends/biote...

Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

Group Leader position available @johninnescentre.bsky.social !

It’s a creative and stimulating environment for plant and/or microbial biology - spanning the full spectrum of fundamental and applied research.

Apply to join us - don’t be shy!

Serial femtosecond crystallography reveals protein dynamics in real time Proteins are constantly moving, but our structures of them are static. Clare Sansom talks to the researchers using free-electron lasers to make time-resolved structures

Proteins are constantly moving, but our structures of them are static. Clare Sansom talks to the researchers using free-electron lasers to make time-resolved structures
www.chemistryworld.c...

Cryo-EM structure of native honey bee vitellogenin | Nature Communications Vitellogenin (Vg) is the main yolk precursor lipoprotein in almost all egg-laying animals. In addition, along its evolutionary history, Vg has developed a range of new functions in different taxa. In the honey bee, Vg has functions related to immunity, antioxidant protection, social behavior and longevity. However, the molecular mechanisms underlying Vg functionalities are still poorly understood. Here, we report the cryo-EM structure of full-length honey bee Vg, one-step purified directly from hemolymph. The structure provides structural insights into the overall domain architecture, including the lipid binding cavity and the previously uncharacterized von Willebrand factor type D domain. A domain of unknown function has been identified as a C-terminal cystine knot domain based on structural homology. Information about post-translational modifications, cleavage products, metal and lipid binding allow an improved understanding of the mechanisms underlying the range of Vg functionalitie

Discover the cryo-EM structure of honey bee vitellogenin, revealing insights into its roles in immunity, antioxidant defense, behavior, & longevity. PMID:40593495, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-58575-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

An awesome review for
"exotic" nucleotides lovers focusing on bacterial/plant/human immunity

with an easy digestible thread 🧵

www.nature.com/articles/s41...

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

The future of bioremediation? Not seeding sites with super-degrader bacteria, but super-fortifying microbiomes of target locations with catabolic genes via HGT. Nature has been doing it forever 💪🏻! Eng community-level function is the way! enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

#cdiAMP Small molecule w/ big roles
We showed that #cdiAMP plays an essential role in regulating natural competence and DNA 🧬 uptake in #cyanobacteria through controlling pilus biogenesis
a great collaboration with @archaellum.bsky.social

Could be interesting for community @cyanotrans.bsky.social

The second messenger c-di-AMP controls natural competence via ComFB signaling protein Cell Discovery - The second messenger c-di-AMP controls natural competence via ComFB signaling protein

Happy to share our latest finding @natureportfolio.nature.com on #cdiAMP signaling roles in #cyanobacteria natural competence via #ComFB (a new family of #cdiNMP receptors)
@hhu.de @cmfi.bsky.social @biologyunifreiburg.bsky.social
Fund @dfg.de @sfb1381.bsky.social
@mibinet.bsky.social
rdcu.be/eyLXT

A nice place to be!
Highly recommend!
I would love to be student again and work with Sebastian ;-)

Very interesting!
@mibinet.bsky.social

www.cell.com/trends/genet...

Microbial metal physiology: ions to ecosystems Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...

Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals

rdcu.be/eycU2

The #YoungScientistAward of the @gdch.de Division of Biochemistry is now open for applications!
If you are or have supervised a current PhD with an outstanding publication or PhD thesis completed in 2025, make sure to check the award and apply!
en.gdch.de/network-s...
#ChemSky #ChemBio #Biochemistry

Global Minds Initiative Germany - BMBF Our Global Minds Initiative Germany offers international research talent career prospects in the German science system. We will thereby lastingly strengthen the German and European Research Area.

Global Minds Initiative Germany: Federal Ministry of Research launches new programme to strengthen Germany as a science location together with the Humboldt Foundation, @dfg.de and @daadworldwide.bsky.social.
www.bmftr.bund.de/EN/Research/...

Congrats Maria, Daniel and team!

Engineering quorum-sensing circuits in Synechococcus elongatus PCC 7942 towards self-inducible systems. Despite significant potential for cyanobacteria as sustainable bioproduction chases, there are limited examples of scaled cyanobacterial bioproduction…

Happy to this story finally published! Happy to a be a part of it!
Congratulations to all the authors!

www.sciencedirect.com/science/arti...

A new doctor is born 😊🥳
Welcome with me Dr. Haffner, the first PhD student of the group after wonderful years @cmfi.bsky.social

Michael published 8 articles & a review with 3 as 1st author..
www.science.org/doi/10.1126/...

www.pnas.org/doi/10.1073/...

Scalable emulation of protein equilibrium ensembles with generative deep learning Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...

Proteins on motion: a new #AI model that rapidly and accurately predicts the full range of shapes a protein can adopt

In @science.org

www.science.org/doi/10.1126/...

From @diamondlab.bsky.social
Stable #cyanobacteria communities w/ heterotrophs. An important development for folks working on cyanobacteria, microbial community formation and establishment in lab settings

Could be interesting for @mibinet.bsky.social

academic.oup.com/ismej/advanc...

"molecular bureaucracy" a very cool terminology!

Genetics, energetics, and allostery in proteins with randomized cores and surfaces A lack of systematic experimental data limits our understanding of protein evolution. In this study, we experimentally characterized proteins with randomized sequences. Vast numbers of amino acid comb...

Spectacular and exciting!!!
www.science.org/doi/10.1126/...

Strategies and mechanisms of contact-dependent predation in bacteria Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…

#MicroSky Summer read!

Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛

How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social

www.sciencedirect.com/science/arti...

Congrats Géraldine! and team 🎉 🎉

The what, when, where, and why of wrinkly morphology in biofilms Wrinkling is a striking emergent behavior that occurs in microbial biofilms across many species. The phenomenon originates from an intricate interplay between e

The what, when, where, and why of wrinkly morphology in biofilms

-in Biophysics Rev

pubs.aip.org/aip/bpr/arti...

ATP synthesis driven by atmospheric hydrogen concentrations | PNAS All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The un...

Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...

Come and join our 2nd international symposium! On protein machineries
@sfb1381.bsky.social ...

Great speakers!

Congrats 🎉 🎉 Laura and team!

The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
www.biorxiv.org/content/10.1...