Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡

We discovered new projects and complementary techniques (watch out NMR and MS is coming back!), hot structural biology topics (new processing algorithms, grids!) and what AI has done (automated structure determination by NMR) or has failed (so far; ligands and RNA) to achieve in Structural Biology

Organized by excellent researchers from Strasbourg (IGBMC) and held inside a Monastery.

Many groups from the region bordering the Rhine, France 🇫🇷 , Switzerland 🇨🇭 and Germany 🇩🇪 listened and discussed how structural biology has moved since the 1990.

Finished an exciting 38th Rhine Knee Structural 🧫💎🔬biology meeting lnkd.in/eYse4giF !

See you back in Switzerland in 2026!

How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...

The latest #AlphaFold DB update is out!

We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction.

Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!

There’s always enough PDL1, EGFR… it’s the new lysozyme

Yes I think they’re just mining from the data they have from previous competitions and also from papers to retest. But it’s still nice to see. I guarantee many of these designs would’ve never been tested again especially in a different lab.

Have heard this being suggested by many, but haven’t seen anything real until now

Hmmm a library of protein designs all assessed for binding on the same platform. All with sequences, both positive and negative data. Makes for much better comparison than those made via paper claims.

proteinbase.com

Shiver

A bar chart showing that TikTok is increasingly a place for news, especially among young U.S. adults. Adults ages 30 to 49 have also increasingly been getting news on TikTok: A quarter now say they do so regularly, up from just 2% five years ago. Much smaller shares of adults ages 50 to 64 and 65 and older say they regularly get news there (10% and 3%, respectively, as of this year).

NEW: In 2025, 43% of young American adults regularly get their news from TikTok.
www.pewresearch.org/short-reads/...

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

Be our neighbour !

tell that to my other neighbour where I can hear their laundry machine turn and shake

I even take baths at night sometimes ☠️ no no no no no

not in geneva!

i just checked, its 2100. www.ge.ch/bruit-voisin...

Ive been living my whole life wrong for the past 10 years 😂

no the correct answer is 2100 with the green check. I put 2200 with the blue dot

Rejected for nationality because I make noise after hours. 😭

But I think these are my fave varieties
‘just marries’, ‘pink suffision’, ‘café au lait’

Tomatoes the size of my full extended palm

Salsa batch #2 of the year

A bouquet of dahlias

View of dahlia plot

Long weekend dump. Torn between going to the 🏔️ or my garden. What did I choose?….

I’m only on epi 4! But I feel similar ways. I still don’t understand this interplay of cyborg, synths and hybrids

Page 1: Flyer from The Heritage Foundation Oversight Project titled “Transgender Ideology-Inspired Violent Extremism (TIVE): Background and FAQs on Need for an FBI Domestic Terrorism Designation.” The page defines “Transgender Ideology” and “TIVE,” outlining beliefs allegedly associated with them. It claims such ideology justifies violence against opponents or frames opposition as violence. The text references the alleged assassination of Charlie Kirk, urging the FBI to classify TIVE as domestic terrorism.

Page 2: Continuation of flyer with a section titled “Recent Instances of TIVE-Motivated Acts of Domestic Terrorism.” Lists multiple violent events from 2018 to 2025, attributing them to transgender ideology. Includes mugshots of two alleged attackers. Followed by a “Frequently Asked Questions and Key Terms” section, addressing whether transgender people are terrorists, comparing TIVE with “Nihilistic Violent Extremism,” and discussing FBI designations.

Page 3: Flyer continues with questions about Antifa and FBI terrorism classifications. States that Antifa and TIVE are separate categories. Lists ways the FBI classifies domestic terrorism and identifies typical characteristics of “TIVEs,” such as targeting Christians, mental illness, and online radicalization. Includes images: a “Trans Antifa” logo, a pink-blue-white-striped slogan image reading “Protect Their Right to Exist,” a photo of Audrey Hale with a firearm, and a close-up of a magazine with the words “Where is your God?”

Page 4: Section titled “Terminology Used by TIVE.” Defines terms including cisgender, deadnaming, Gillick competence, misgendering, “Right to Exist,” “Trans genocide,” and a phrase “You either have a live boy or dead girl, you choose.” Each is presented as terminology used in or associated with TIVE. Page layout is text-heavy, no additional graphics.

Heritage Foundation has released an absolutely insane policy proposal to label all trans people as domestic terrorists. It uses completely made up instances of terrorism and made up statistics but facts don't matter to them.

They want us all eradicated.

Now they just need to get a HK cafe style food trend happening

I was just listening to the soundtrack yesterday! And I just applied this today. What’s going on!!

Shouldn’t have been that difficult… found press release before the preprint.. and that link I had to find on X

Generative design of novel bacteriophages with genome language models Many important biological functions arise not from single genes, but from complex interactions encoded by entire genomes. Genome language models have emerged as a promising strategy for designing biol...

found it! www.biorxiv.org/content/10.1...

anyone can find the preprint? I only found : arcinstitute.org/news/hie-kin...

Many of the most complex and useful functions in biology emerge at the scale of whole genomes.

Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵