Tulsi Upadhyay

Excited to share my First GRS and GRC moments. It was very special #Bioorganic GRC2025. Met my PhD advisor @saraogi-ishu.bsky.social. Great Science and networking. Won “Outstanding Poster” award.

Thanks to my postdoc advisor @mbogyo.bsky.social for the opportunity to present in GRC with him.

25.06.2025 20:39 — 👍 3    🔁 0    💬 0    📌 0

@jeyunjo.bsky.social @christianslentz.bsky.social @jalal228.bsky.social @sijiewang.bsky.social

30.05.2025 23:29 — 👍 1    🔁 1    💬 1    📌 0

I'm thrilled to share that my second paper from my postdoctoral work is now published! A heartfelt thank you to my PI, Prof. Bogyo @mbogyo.bsky.social, for his unwavering support throughout this project. I am also deeply grateful to our fantastic collaboration team for making it a great success.🙌

30.05.2025 23:26 — 👍 7    🔁 1    💬 1    📌 0

a figure from a scientific paper depicting the fluorescent reporter assay for chikungunya virus protease activity. in places where the protease is inactive, there will be no fluorescent signal due to the physical proximity of the quencher and the donor (linked by a peptide substrate). where the protease is active, the peptide substrate will be cleaved and will free the donor from the influence of the quencher and thus produce a fluorescent signal upon excitation.

🧪 Working to develop #drugs to treat #chikungunya ? Check out new fluorogenic substrates that help read out viral protease activity, developed by @tulsiupadhyay.bsky.social @westberglab.com @eunayoo.bsky.social @michaelzlin.bsky.social et al! pubmed.ncbi.nlm.nih.gov/39981948/

03.03.2025 20:57 — 👍 5    🔁 2    💬 0    📌 0

Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets. R...

Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...

25.02.2025 02:51 — 👍 30    🔁 11    💬 1    📌 0

Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ...

New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...

11.02.2025 08:38 — 👍 16    🔁 6    💬 0    📌 2

Another big publication from @sijiewang.bsky.social this week. Check out our efforts to use mRNA display to screen for covalent binding inhibitors of Staphylococcus aureus serine hydrolases. pubs.acs.org/articlesonre...

27.02.2025 16:54 — 👍 19    🔁 4    💬 3    📌 0

Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. This is largely because infection sites are often difficult to localize and the bacteria forms biofilms which are n...

Cool new preprint from @stanford-chemh.bsky.social fellow @mbogyo.bsky.social @stanfordmedicine.bsky.social

www.researchsquare.com/article/rs-5...

10.01.2025 13:03 — 👍 24    🔁 8    💬 0    📌 0

Excited to repost the news on this new platform!! Great collaborative work under the mentorship of @mbogyo.bsky.social is out for your read.

10.01.2025 19:53 — 👍 3    🔁 1    💬 0    📌 0